Target Information
| Target General Information | Top | |||||
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| Target ID |
T93147
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| Target Name |
Transgelin-2 (TAGLN2)
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| Synonyms |
SM22-alpha homolog; KIAA0120; Epididymis tissue protein Li 7e
Click to Show/Hide
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| Gene Name |
TAGLN2
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
cytosol, extracellular exosome, extracellular region, vesicle, cadherin binding, epithelial cell differentiation, platelet degranulation.
Click to Show/Hide
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| BioChemical Class |
Calponin family
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| UniProt ID | ||||||
| Sequence |
MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGT
VLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGK NMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGT NRGASQAGMTGYGMPRQIL Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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| Protein Name | Pfam ID | Percentage of Identity (%) | E value |
|---|---|---|---|
| Guanine nucleotide exchange factor VAV2 (VAV2) | 25.275 (23/91) | 4.00E-03 | |
| Guanine nucleotide exchange factor VAV3 (VAV3) | 28.571 (26/91) | 5.00E-03 |
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| Target Regulators | Top | |||||
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| Target-interacting Proteins | ||||||
| References | Top | |||||
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| REF 1 | Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer. J Exp Clin Cancer Res. 2018 Jul 24;37(1):166. | |||||
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