Target Information
Target General Information | Top | |||||
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Target ID |
T93145
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Target Name |
Pyruvate dehydrogenase kinase (PDHK)
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Synonyms |
PDH kinase
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Gene Name |
NO-GeName
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Target Type |
Clinical trial target
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[1] | ||||
Disease | [+] 3 Target-related Diseases | + | ||||
1 | Pulmonary hypertension [ICD-11: BB01] | |||||
2 | Heart failure [ICD-11: BD10-BD1Z] | |||||
3 | Type 2 diabetes mellitus [ICD-11: 5A11] | |||||
BioChemical Class |
Kinase
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UniProt ID |
Drugs and Modes of Action | Top | |||||
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Clinical Trial Drug(s) | [+] 2 Clinical Trial Drugs | + | ||||
1 | JTT-251 | Drug Info | Phase 2 | Pulmonary arterial hypertension | [2] | |
2 | JTT-861 | Drug Info | Phase 1 | Chronic heart failure | [3] | |
Mode of Action | [+] 1 Modes of Action | + | ||||
Inhibitor | [+] 2 Inhibitor drugs | + | ||||
1 | JTT-251 | Drug Info | [1] | |||
2 | JTT-861 | Drug Info | [3] |
Chemical Structure based Activity Landscape of Target | Top |
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Target Poor or Non Binders | Top | |||||
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Target Poor or Non Binders |
References | Top | |||||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
REF 2 | ClinicalTrials.gov (NCT03789643) Study to Evaluate Efficacy and Safety of JTT-251 in Participants With Pulmonary Arterial Hypertension (RELIEF-PAH). U.S. National Institutes of Health. | |||||
REF 3 | Clinical pipeline report, company report or official report of Akros Pharma |
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