Target Information
| Target General Information | Top | |||||
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| Target ID |
T87916
(Former ID: TTDR01374)
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| Target Name |
E-selectin messenger RNA (SELE mRNA)
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| Synonyms |
Leukocyte-endothelial cell adhesion molecule 2 (mRNA); LECAM2 (mRNA); Endothelial leukocyte adhesion molecule 1 (mRNA); ELAM1 (mRNA); ELAM-1 (mRNA); E-selectin (mRNA); CD62E antigen (mRNA); CD62E (mRNA); CD62 antigen-like family member E (mRNA)
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| Gene Name |
SELE
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. Cell-surface glycoprotein having a role in immunoadhesion.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLN
SILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREK DVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNC TALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVV ECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIP VCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDN EKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ WTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHW SGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESD GSYQKPSYIL Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 4 KEGG Pathways | + | ||||
| 1 | Cell adhesion molecules (CAMs) | |||||
| 2 | TNF signaling pathway | |||||
| 3 | African trypanosomiasis | |||||
| 4 | Malaria | |||||
| NetPath Pathway | [+] 4 NetPath Pathways | + | ||||
| 1 | IL5 Signaling Pathway | |||||
| 2 | IL4 Signaling Pathway | |||||
| 3 | TNFalpha Signaling Pathway | |||||
| 4 | ID Signaling Pathway | |||||
| PID Pathway | [+] 3 PID Pathways | + | ||||
| 1 | Thromboxane A2 receptor signaling | |||||
| 2 | Glucocorticoid receptor regulatory network | |||||
| 3 | ATF-2 transcription factor network | |||||
| Reactome | [+] 1 Reactome Pathways | + | ||||
| 1 | Cell surface interactions at the vascular wall | |||||
| WikiPathways | [+] 3 WikiPathways | + | ||||
| 1 | Human Complement System | |||||
| 2 | TNF alpha Signaling Pathway | |||||
| 3 | Cell surface interactions at the vascular wall | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2. | |||||
| REF 2 | US patent application no. 5,843,738, Oligonucleotide modulation of cell adhesion. | |||||
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