Target Information
| Target General Information | Top | |||||
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| Target ID |
T86671
(Former ID: TTDI01806)
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| Target Name |
Orexin receptor (HCRTR)
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| Synonyms |
Hypocretin receptor
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| Gene Name |
NO-GeName
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| Target Type |
Successful target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Insomnia [ICD-11: 7A00-7A0Z] | |||||
| Function |
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.
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| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
| 1 | Daridorexant | Drug Info | Approved | Insomnia | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Antagonist | [+] 2 Antagonist drugs | + | ||||
| 1 | Daridorexant | Drug Info | [2] | |||
| 2 | 1,2-diamino cyclopentane-based derivative 28 | Drug Info | [1] | |||
| References | Top | |||||
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| REF 1 | Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. | |||||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 214985. | |||||
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