Target Information
Target General Information | Top | |||||
---|---|---|---|---|---|---|
Target ID |
T86513
|
|||||
Target Name |
HUMAN interleukin-6 receptor (IL6R)
|
|||||
Synonyms |
Membrane glycoprotein; Interleukin-6 receptor; IL-6R; IL-6 receptor
Click to Show/Hide
|
|||||
Gene Name |
IL6R; IL6ST
|
|||||
Disease | [+] 2 Target-related Diseases | + | ||||
1 | Rheumatoid arthritis [ICD-11: FA20] | |||||
2 | Vasculitis [ICD-11: 4A44] | |||||
Function |
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Click to Show/Hide
|
|||||
BioChemical Class |
Cytokine receptor
|
|||||
UniProt ID | ||||||
Sequence |
MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHW
VLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLS CFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAV PEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQD PHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSS SVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRP TPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR Click to Show/Hide
|
Drugs and Modes of Action | Top | |||||
---|---|---|---|---|---|---|
Drugs in Phase 3 Trial | [+] 2 | + | ||||
1 | Sarilumab | Drug Info | Approved | Rheumatoid arthritis | [2] | |
2 | Tocilizumab | Drug Info | Approved | Giant cell arteritis | [2] | |
Mode of Action | [+] 2 Modes of Action | + | ||||
Blocker | [+] 1 Blocker drugs | + | ||||
1 | Sarilumab | Drug Info | [3], [4] | |||
Inhibitor | [+] 1 Inhibitor drugs | + | ||||
1 | Tocilizumab | Drug Info | [1] |
References | Top | |||||
---|---|---|---|---|---|---|
REF 1 | Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report. Ann Oncol. 2020 Apr 2. pii: S0923-7534(20)36387-0. | |||||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
REF 3 | IL-6 as a keystone cytokine in health and disease. Nat Immunol. 2015 May;16(5):448-57. | |||||
REF 4 | WHAT IS KEVZARA |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.