Target Information
Target General Information | Top | |||||
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Target ID |
T85056
(Former ID: TTDR01421)
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Target Name |
Cytohesin-2 messenger RNA (CYTH2 mRNA)
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Synonyms |
Protein ARNO (mRNA); PSCD2L (mRNA); PSCD2 (mRNA); PH, SEC7 and coiled-coil domain-containing protein 2 (mRNA); Cytohesin-2 (mRNA); CYTH2 (mRNA); ARNO (mRNA); ARF nucleotide-binding site opener (mRNA); ARF exchange factor (mRNA)
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Gene Name |
CYTH2
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Target Type |
Literature-reported target
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[1] | ||||
Function |
Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. Involved in neurite growth. Acts as a guanine-nucleotide exchange factor (GEF).
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BioChemical Class |
mRNA target
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UniProt ID | ||||||
Sequence |
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP Click to Show/Hide
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Cell-based Target Expression Variations | Top | |||||
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Cell-based Target Expression Variations |
Target Affiliated Biological Pathways | Top | |||||
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KEGG Pathway | [+] 1 KEGG Pathways | + | ||||
1 | Endocytosis | |||||
PID Pathway | [+] 3 PID Pathways | + | ||||
1 | Arf6 signaling events | |||||
2 | Class I PI3K signaling events | |||||
3 | Arf1 pathway |
References | Top | |||||
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REF 1 | US patent application no. 6,271,029, Antisense inhibition of cytohesin-2 expression. |
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