Target Information
| Target General Information | Top | |||||
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| Target ID |
T82372
(Former ID: TTDR01418)
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| Target Name |
STXBP4 messenger RNA (STXBP4 mRNA)
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| Synonyms |
Syntaxin-binding protein 4 (mRNA); Syntaxin 4-interacting protein (mRNA); Synip (mRNA); STX4-interacting protein (mRNA)
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| Gene Name |
STXBP4
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK
DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLESAWEIAFIRQKSDNIQPENLSC TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN EEDCSRELPNQKS Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| PID Pathway | [+] 2 PID Pathways | + | ||||
| 1 | Validated transcriptional targets of deltaNp63 isoforms | |||||
| 2 | Insulin-mediated glucose transport | |||||
| WikiPathways | [+] 1 WikiPathways | + | ||||
| 1 | Insulin Signaling | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,503,756, Antisense modulation of syntaxin 4 interacting protein expression. | |||||
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