Target Information
| Target General Information | Top | |||||
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| Target ID |
T81547
(Former ID: TTDR00899)
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| Target Name |
Solute carrier family 13 member 5 (SLC13A5)
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| Synonyms |
Sodium-coupled citrate transporter; SLC13A5; NaCT; Na(+)-coupled citrate transporter; Human sodium-coupled citrate transporter
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| Gene Name |
SLC13A5
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.
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| UniProt ID | ||||||
| Sequence |
MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTS
LMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAK PARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKE LPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNEL FPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALK VLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVA IFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFAL AKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMS RSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCV FLAVNTWGRAIFDLDHFPDWANVTHIET Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: (2R)-2-[2-(4-tert-butylphenyl)ethyl]-2-hydroxybutanedioic acid | Ligand Info | |||||
| Structure Description | Structure of the NaCT-PF2 complex | PDB:7JSJ | ||||
| Method | Electron microscopy | Resolution | 3.12 Å | Mutation | No | [2] |
| PDB Sequence |
SFVILFVTPL
22 LLLPLVILMP32 AKFVRCAYVI42 ILMAIYWCTE52 VIPLAVTSLM62 PVLLFPLFQI 72 LDSRQVCVQY82 MKDTNMLFLG92 GLIVAVAVER102 WNLHKRIALR112 TLLWVGAKPA 122 RLMLGFMGVT132 ALLSMWISNT142 ATTAMMVPIV152 EAILQQRKRL204 CKAMTLCICY 214 AASIGGTATL224 TGTGPNVVLL234 GQMNELFPDS244 KDLVNFASWF254 AFAFPNMLVM 264 LLFAWLWLQF274 VYMRSKKNEK296 AALKVLQEEY306 RKLGPLSFAE316 INVLICFFLL 326 VILWFSRDPE350 TKYVSDATVA360 IFVATLLFIV370 PSQKPKFYPP394 PLLDWKVTQE 404 KVPWGIVLLL414 GGGFALAKGS424 EASGLSVWMG434 KQMEPLHAVP444 PAAITLILSL 454 LVAVFTECTS464 NVATTTLFLP474 IFASMSRSIG484 LNPLYIMLPC494 TLSASFAFML 504 PVATPPNAIV514 FTYGHLKVAD524 MVKTGVIMNI534 IGVFCVFLAV544 NTWGRAIFDL 554 DHFPDWAN
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LEU56
2.955
ALA57
3.956
PHE90
3.925
SER140
3.068
ASN141
2.530
THR142
2.290
GLY226
3.723
THR227
1.640
GLY228
2.418
PRO229
3.344
PRO407
2.696
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| Chemical Structure based Activity Landscape of Target | Top |
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| References | Top | |||||
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| REF 1 | Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action. Biochem J. 2003 Aug 15;374(Pt 1):21-6. | |||||
| REF 2 | Structure and inhibition mechanism of the human citrate transporter NaCT. Nature. 2021 Mar;591(7848):157-161. | |||||
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