Target Information
| Target General Information | Top | |||||
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| Target ID |
T81409
(Former ID: TTDI00173)
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| Target Name |
Septin-6 (SEPT6)
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| Synonyms |
KIAA0128
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| Gene Name |
SEPTIN6
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.
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| UniProt ID | ||||||
| Sequence |
MAATDIARQVGEGCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMD
TLFNTKFEGEPATHTQPGVQLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVE FIDAQFEAYLQEELKIRRVLHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNII PIIAKADAISKSELTKFKIKITSELVSNGVQIYQFPTDDESVAEINGTMNAHLPFAVIGS TEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIRVNMEDLREQTHTRHYELYRR CKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEA EKELHEKFDRLKKLHQDEKKKLEDKKKSLDDEVNAFKQRKTAAELLQSQGSQAGGSQTLK RDKEKKNNPWLCTE Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Guanosine-5'-Diphosphate | Ligand Info | |||||
| Structure Description | Crystal Structure of GTPase Domain of Human Septin 2/Septin 6 Heterocomplex | PDB:6UPA | ||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | No | [2] |
| PDB Sequence |
FCFNILCVGE
50 TGLGKSTLMD60 TLFNTKFEPA72 THTQPGVQLQ82 SNTYDLRLKL97 TIVSTVGFGD 107 QINKEDSYKP117 IVEFIDAQFE127 AYLQEELKIR137 RVLHTYHDSR147 IHVCLYFIAP 157 TGHSLKSLDL167 VTMKKLDSKV177 NIIPIIAKAD187 AISKSELTKF197 KIKITSELVS 207 NGVQIYQFPT217 DDESVAEING227 TMNAHLPFAV237 IGSTEELKIG247 NKMMRARQYP 257 WGTVQVENEA267 HCDFVKLREM277 LIRVNMEDLR287 EQTHTRHYEL297 YRRCKLEE |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Guanosine-5'-Triphosphate | Ligand Info | |||||
| Structure Description | Crystal Structure of GTPase Domain of Human Septin 2/Septin 6 Heterocomplex | PDB:6UPA | ||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | No | [2] |
| PDB Sequence |
FCFNILCVGE
50 TGLGKSTLMD60 TLFNTKFEPA72 THTQPGVQLQ82 SNTYDLRLKL97 TIVSTVGFGD 107 QINKEDSYKP117 IVEFIDAQFE127 AYLQEELKIR137 RVLHTYHDSR147 IHVCLYFIAP 157 TGHSLKSLDL167 VTMKKLDSKV177 NIIPIIAKAD187 AISKSELTKF197 KIKITSELVS 207 NGVQIYQFPT217 DDESVAEING227 TMNAHLPFAV237 IGSTEELKIG247 NKMMRARQYP 257 WGTVQVENEA267 HCDFVKLREM277 LIRVNMEDLR287 EQTHTRHYEL297 YRRCKLEE |
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GLU50
4.092
THR51
3.569
GLY52
3.158
LEU53
3.229
GLY54
2.974
LYS55
2.528
SER56
2.806
THR57
2.680
GLU70
4.519
PRO71
3.518
ALA72
2.572
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors
of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information
(Front Pharmacol, 9, 1245, 2018;
Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| Degree | 8 | Degree centrality | 8.59E-04 | Betweenness centrality | 1.59E-05 |
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| Closeness centrality | 1.87E-01 | Radiality | 1.32E+01 | Clustering coefficient | 7.14E-01 |
| Neighborhood connectivity | 8.13E+00 | Topological coefficient | 4.51E-01 | Eccentricity | 13 |
| Download | Click to Download the Full PPI Network of This Target | ||||
| References | Top | |||||
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| REF 1 | Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. Exp Hematol. 2017 Nov;55:45-55. | |||||
| REF 2 | Molecular Recognition at Septin Interfaces: The Switches Hold the Key. J Mol Biol. 2020 Oct 2;432(21):5784-5801. | |||||
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