Target Information
Target General Information | Top | |||||
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Target ID |
T79249
(Former ID: TTDR01172)
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Target Name |
Thymidylate synthase messenger RNA (TYMS mRNA)
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Synonyms |
TSase (mRNA); TS (mRNA); OK/SW-cl.29 (mRNA)
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Gene Name |
TYMS
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Target Type |
Successful target
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[1] | ||||
Disease | [+] 1 Target-related Diseases | + | ||||
1 | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||||
Function |
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
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BioChemical Class |
mRNA target
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UniProt ID | ||||||
EC Number |
EC 2.1.1.45
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Sequence |
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG YNPHPTIKMEMAV Click to Show/Hide
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Drugs and Modes of Action | Top | |||||
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Approved Drug(s) | [+] 1 Approved Drugs | + | ||||
1 | Fluorouracil | Drug Info | Approved | Solid tumour/cancer | [2] |
Cell-based Target Expression Variations | Top | |||||
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Cell-based Target Expression Variations |
References | Top | |||||
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REF 1 | Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. | |||||
REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. |
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