Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Target Poor or Non Binders
Target Affiliated Biological Pathways
References
Drug Binding Sites of Target  Top
Ligand Name: 6-methyl-2-oxo-2H-chromene-3-carboxylic acid Ligand Info
Structure Description Human kallikrein 7 with aromatic coumarinic ester compound 2 covalently bound to H57 PDB:6SHI
Method X-ray diffraction Resolution 1.85 Å Mutation No [4]
PDB Sequence
IIDGAPCARG
25
SHPWQVALLS
35
GNQLHCGGVL
46
VNERWVLTAA
56
HCKMNEYTVH
67

LGSDTLGDRR
79
AQRIKASKSF
89
RHPGYSTQTH
99
VNDLMLVKLN
109
SQARLSSMVK
119

KVRLPSRCEP
131
PGTTCTVSGW
141
GTTTSPDVTF
151
PSDLMCVDVK
161
LISPQDCTKV
171

YKDLLENSML
181
CAGIPDSKKN
189
ACNGDSGGPL
199
VCRGTLQGLV
213
SWGTFPCGQP
222

NDPGVYTQVC
232
KFTKWINDTM
242
KKHR
Residue
Distance (Å)
LEU40
3.184
HIS41
3.039
CYS42
3.780
HIS57
1.474
CYS58
4.160
Residue
Distance (Å)
PHE151
3.663
ASN192
3.184
GLY193
3.251
SER195
3.336
Ligand Name: 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Ligand Info
Structure Description High resolution structure of Human Kallikrein 7 in Complex with Suc-Ala-Ala-Pro-Phe-chloromethylketone PDB:2QXI
Method X-ray diffraction Resolution 1.00 Å Mutation No [5]
PDB Sequence
IIDGAPCARG
25
SHPWQVALLS
35
GNQLHCGGVL
46
VNERWVLTAA
56
HCKMNEYTVH
66

LGSDTLGDRR
77
AQRIKASKSF
89
RHPGYSTQTH
99
VNDLMLVKLN
109
SQARLSSMVK
119

KVRLPSRCEP
130
PGTTCTVSGW
141
GTTTSPDVTF
151
PSDLMCVDVK
161
LISPQDCTKV
171

YKDLLENSML
181
CAGIPDSKKN
189
ACNGDSGGPL
199
VCRGTLQGLV
213
SWGTFPCGQP
222

NDPGVYTQVC
232
KFTKWINDTM
242
KKHR
Residue
Distance (Å)
HIS41
4.872
CYS42
4.269
HIS57
1.502
CYS58
4.347
HIS99
3.755
LEU175
4.148
ALA190
3.425
CYS191
3.486
ASN192
3.628
GLY193
3.219
ASP194
3.702
Residue
Distance (Å)
SER195
1.403
VAL213
4.083
SER214
2.870
TRP215
3.175
GLY216
2.798
THR217
3.106
PHE218
2.706
PRO219
4.471
CYS220
3.631
GLN221
2.885
ASP224
4.578
Click to View More Binding Site Information of This Target and Ligand Pair
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.

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