Target Information
| Target General Information | Top | |||||
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| Target ID |
T78350
(Former ID: TTDI01503)
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| Target Name |
Melanoma derived growth regulator (MIA)
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| Synonyms |
Melanoma-derived growth regulatory protein; Melanoma inhibitory activity protein
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| Gene Name |
MIA
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
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| UniProt ID | ||||||
| Sequence |
MARSLVCLGVIILLSAFSGPGVRGGPMPKLADRKLCADQECSHPISMAVALQDYMAPDCR
FLTIHRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGYFPSSIVREDQTLKPGKVD VKTDKWDFYCQ Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: 2-Aminopyrimidine | Ligand Info | |||||
| Structure Description | Structure of human Melanoma Inhibitory Activity (MIA) Protein in complex with Pyrimidin-2-amine | PDB:5IXB | ||||
| Method | X-ray diffraction | Resolution | 1.39 Å | Mutation | No | [2] |
| PDB Sequence |
MPKLADRKLC
12 ADQECSHPIS22 MAVALQDYMA32 PDCRFLTIHR42 GQVVYVFSKL52 KGRGRLFWGG 62 SVQGDYYGDL72 AARLGYFPSS82 IVREDQTLKP92 GKVDVKTDKW102 DFYCQ |
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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| Protein Name | Pfam ID | Percentage of Identity (%) | E value |
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| Jouberin (AHI1) | 35.227 (31/88) | 3.58E-04 |
| References | Top | |||||
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| REF 1 | Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells. Immunol Cell Biol. 2016 Jan;94(1):24-38. | |||||
| REF 2 | Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma. Sci Rep. 2016 May 6;6:25119. | |||||
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