Target Information

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Target General Information
Drugs and Modes of Action
Different Human System Profiles of Target
Target Profiles in Patients
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Human Similarity Proteins
Human Pathway Affiliation
Protein Name Pfam ID Percentage of Identity (%) E value
Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5)
PF07679 ; 
PF13306
28.169 (80/284) 7.99E-19
Platelet glycoprotein Ib beta chain (GP1BB)
PF01463
33.333 (28/84) 4.58E-08
Follicle-stimulating hormone receptor (FSHR)
PF00001 ; 
PF12369 ; 
PF13306 ; 
PF01462
More >>
 32.222 (29/90) 3.12E-05
Protein phosphatase 1 regulatory subunit 7 (PPP1R7)
PF14580
30.872 (46/149) 3.40E-04
X-ray radiation resistance-associated protein 1 (XRRA1) 27.564 (43/156) 8.95E-04
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
Cell adhesion molecules hsa04514 Affiliated Target
  Class: Environmental Information Processing => Signaling molecules and interaction Pathway Hierarchy

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