Target Information
| Target General Information | Top | |||||
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| Target ID |
T63234
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| Target Name |
Cytochrome bc1 complex cytochrome b subunit (qcrB)
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| Synonyms |
Cytochrome bc1 reductase complex subunit QcrB; Ubiquinol--cytochrome c reductase cytochrome b subunit
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| Gene Name |
qcrB
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| Target Type |
Preclinical target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | HIV-infected patients with tuberculosis [ICD-11: 1B10-1B14] | |||||
| Function |
Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. The cytochrome b subunit contains two ubiquinol reactive sites: the oxidation (QP) site and the reduction (QN) site. {ECO:0000305, ECO:0000305|PubMed:23913123, ECO:0000305|PubMed:26158909}.
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| BioChemical Class |
Cytochrome b family
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| UniProt ID | ||||||
| EC Number |
EC 7.1.1.8
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| Sequence |
MSPKLSPPNIGEVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSFLLGEIALYSFVVLLI
TGVYLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISFEVRGGLFVRQIHHWAALM FAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFGYSLPDDLLSGLGLRAAL SSITLGMPVIGTWLHWALFGGDFPGTILIPRLYALHILLLPGIILALIGLHLALVWFQKH TQFPGPGRTEHNVVGVRVMPVFAFKSGAFFAAIVGVLGLMGGLLQINPIWNLGPYKPSQV SAGSQPDFYMMWTEGLARIWPPWEFYFWHHTIPAPVWVAVIMGLVFVLLPAYPFLEKRFT GDYAHHNLLQRPRDVPVRTAIGAMAIAFYMVLTLAAMNDIIALKFHISLNATTWIGRIGM VILPPFVYFITYRWCIGLQRSDRSVLEHGVETGIIKRLPHGAYIELHQPLGPVDEHGHPI PLQYQGAPLPKRMNKLGSAGSPGSGSFLFADSAAEDAALREAGHAAEQRALAALREHQDS IMGSPDGEH Click to Show/Hide
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| Drugs and Modes of Action | Top | |||||
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| Preclinical Drug(s) | [+] 1 Preclinical Drugs | + | ||||
| 1 | TB47 | Drug Info | Preclinical | Tuberculosis | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 1 Inhibitor drugs | + | ||||
| 1 | TB47 | Drug Info | [1] | |||
| References | Top | |||||
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| REF 1 | The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0096421. | |||||
| REF 2 | The QcrB Inhibitors TB47 and Telacebec Do Not Potentiate the Activity of Clofazimine in Mycobacterium abscessus. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0096421. | |||||
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