Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T59174
(Former ID: TTDI01757)
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| Target Name |
Sodium/hydrogen exchanger (SLC)
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| Gene Name |
NO-GeName
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| Target Type |
Literature-reported target
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[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Hypertension [ICD-11: BA00-BA04] | |||||
| 2 | Myocardial infarction [ICD-11: BA41-BA43] | |||||
| Function |
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
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| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Discontinued Drug(s) | [+] 1 Discontinued Drugs | + | ||||
| 1 | FR-183998 | Drug Info | Terminated | Hypertension | [2] | |
| Mode of Action | [+] 2 Modes of Action | + | ||||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | FR-183998 | Drug Info | [1] | |||
| Inhibitor | [+] 1 Inhibitor drugs | + | ||||
| 1 | Rimeporide | Drug Info | [3] | |||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 10 KEGG Pathways | + | ||||
| 1 | cAMP signaling pathway | |||||
| 2 | Cardiac muscle contraction | |||||
| 3 | Adrenergic signaling in cardiomyocytes | |||||
| 4 | Regulation of actin cytoskeleton | |||||
| 5 | Thyroid hormone signaling pathway | |||||
| 6 | Salivary secretion | |||||
| 7 | Gastric acid secretion | |||||
| 8 | Pancreatic secretion | |||||
| 9 | Bile secretion | |||||
| 10 | Proteoglycans in cancer | |||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30(3):311-7. | |||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009190) | |||||
| REF 3 | Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation. 2007 Mar 6;115(9):1090-100. | |||||
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