Target Information

Target General Information

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Target ID

T55005 (Former ID: TTDI03414)

Target Name

NUAK family SNF1-like kinase 2 (NUAK2)

Synonyms

SNF1/AMP kinase-related kinase; SNARK; Omphalocele kinase 2; OMPHK2

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Gene Name

NUAK2

Target Type

Literature-reported target

[1]

Function

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.

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UniProt ID

NUAK2_HUMAN

EC Number

EC 2.7.11.1

Sequence

MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG
KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE
NSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN
ILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLL
YILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASH
WWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPG
GGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAE
GVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVS
GDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPS
GAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPL
GDSCFSLTDCQEVTATYRQALRVCSKLT

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3D Structure

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AlphaFold

HIT2.0 ID

T59ZYY

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Titin (TTN)		28.509 (65/228)	3.18E-27
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)	PF07714	29.767 (64/215)	9.07E-26
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)	PF07714	27.419 (68/248)	1.32E-24
MLK-related kinase (MLTK)	PF07714 ; PF00536	32.683 (67/205)	4.05E-24
Mixed lineage kinase 3 (MAP3K11)	PF07714 ; PF14604	32.381 (68/210)	9.38E-24
Tyrosine-protein kinase ABL1 (ABL)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	27.491 (80/291)	2.10E-22
Tyrosine-protein kinase Srms (SRMS)	PF07714 ; PF00017	29.151 (79/271)	5.83E-22
Tyrosine-protein kinase Tec (PSCTK4)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	26.906 (60/223)	6.60E-22
Inactive tyrosine-protein kinase 7 (PTK7)	PF07679 ; PF13927 ; PF07714 More >>	27.817 (79/284)	1.07E-21
Tyrosine-protein kinase ABL2 (ABL2)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	27.835 (81/291)	5.58E-21
Ephrin type-A receptor 1 (EPHA1)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	29.596 (66/223)	1.29E-20
Focal adhesion kinase 1 (FAK)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	25.828 (78/302)	1.49E-20
Mixed lineage kinase 2 (MAP3K10)	PF07714 ; PF14604	30.189 (64/212)	2.25E-20
T-cell-specific kinase (ITK)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	27.315 (59/216)	2.40E-20
LIM domain kinase-2 (LIMK-2)	PF00412 ; PF00595 ; PF07714 More >>	27.143 (57/210)	2.83E-20
BDNF/NT-3 growth factors receptor (TrkB)	PF07679 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	26.437 (69/261)	3.60E-20
Tyrosine-protein kinase Lyn (JTK8)	PF07714 ; PF00017 ; PF00018 More >>	26.991 (61/226)	7.11E-20
B lymphocyte kinase (BLK)	PF07714 ; PF00017 ; PF00018 More >>	28.846 (75/260)	8.52E-20
Ephrin type-B receptor 4 (EPHB4)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	27.948 (64/229)	9.62E-20
Neurotrophic tyrosine kinase ROR2 (ROR2)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	26.140 (86/329)	9.69E-20
Janus kinase 2 (JAK-2)	PF18379 ; PF18377 ; PF17887 ; PF07714 ; PF00017 More >>	31.034 (63/203)	9.76E-20
Tyrosine-protein kinase BRK (PTK6)	PF07714 ; PF00017 ; PF00018 More >>	28.319 (64/226)	1.40E-19
Tyrosine-protein kinase BTK (ATK)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	26.389 (57/216)	2.28E-19
LIM domain kinase-1 (LIMK-1)	PF00412 ; PF00595 ; PF07714 More >>	25.483 (66/259)	2.30E-19
Hematopoietic cell kinase (HCK)	PF07714 ; PF00017 ; PF00018 More >>	26.744 (69/258)	2.44E-19
Muscle-specific kinase receptor (MUSK)	PF01392 ; PF07679 ; PF13927 ; PF07714 More >>	25.000 (71/284)	2.47E-19
Serine/threonine-protein kinase TNNI3K (TNNI3K)	PF12796 ; PF13637 ; PF07714 More >>	26.357 (68/258)	2.59E-19
Serine/threonine-protein kinase LMTK1 (AATK)	PF07714	27.106 (74/273)	3.18E-19
Fibroblast growth factor receptor 1 (FGFR1)	PF07679 ; PF00047 ; PF07714 More >>	27.562 (78/283)	4.20E-19
Tyrosine-protein kinase TXK (TXK)	PF07714 ; PF00017 ; PF00018 More >>	26.977 (58/215)	5.59E-19
Mixed lineage kinase 4 (MAP3K21)	PF07714 ; PF14604	29.060 (68/234)	1.12E-18
LCK tyrosine protein kinase (LCK)	PF07714 ; PF00017 ; PF00018 More >>	26.070 (67/257)	1.52E-18
Angiopoietin 1 receptor (TEK)	PF00041 ; PF10430 ; PF07714 More >>	30.612 (75/245)	2.18E-18
Fibroblast growth factor receptor 3 (FGFR3)	PF07679 ; PF13927 ; PF07714 More >>	25.000 (70/280)	3.00E-18
Tyrosine-protein kinase FRK (FRK)	PF07714 ; PF00017 ; PF00018 More >>	26.446 (64/242)	3.50E-18
Janus kinase 3 (JAK-3)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	31.068 (64/206)	3.54E-18
Proto-oncogene c-Src (SRC)	PF07714 ; PF00017 ; PF00018 More >>	29.545 (65/220)	3.67E-18
ALK tyrosine kinase receptor (ALK)	PF12810 ; PF00629 ; PF07714 More >>	27.572 (67/243)	3.70E-18
NT-3 growth factor receptor (TrkC)	PF07679 ; PF00047 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	26.378 (67/254)	4.65E-18
TYK2 tyrosine kinase (TYK2)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	31.000 (62/200)	5.68E-18
Neurotrophic tyrosine kinase ROR1 (ROR1)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	24.088 (66/274)	5.74E-18
Ephrin type-A receptor 3 (EPHA3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF07647 More >>	28.571 (70/245)	5.85E-18
Tyrosine-protein kinase BMX (BMX)	PF00779 ; PF00169 ; PF07714 ; PF00017 More >>	24.806 (64/258)	6.43E-18
Fyn tyrosine protein kinase (FYN)	PF07714 ; PF00017 ; PF00018 More >>	29.885 (78/261)	8.22E-18
TGF-beta-activated kinase 1 (MAP3K7)	PF07714	28.958 (75/259)	8.38E-18
Proto-oncogene c-Ret (RET)	PF00028 ; PF07714 ; PF17756 ; PF17812 ; PF17813 More >>	27.046 (76/281)	9.36E-18
Ephrin type-B receptor 1 (EPHB1)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	27.419 (68/248)	9.84E-18
Ephrin type-A receptor 2 (EPHA2)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	26.744 (69/258)	1.17E-17
Fibroblast growth factor receptor 4 (FGFR4)	PF07679 ; PF13927 ; PF07714 More >>	26.071 (73/280)	1.37E-17
Tie-1 tyrosine kinase receptor (TIE1)	PF00041 ; PF00047 ; PF07714 More >>	28.216 (68/241)	1.51E-17
Yes tyrosine kinase (YES)	PF07714 ; PF00017 ; PF00018 More >>	29.317 (73/249)	1.70E-17
Fibroblast growth factor receptor 2 (FGFR2)	PF07679 ; PF13927 ; PF07714 More >>	26.033 (63/242)	5.15E-17
Tyrosine-protein kinase CSK (CSK)	PF07714 ; PF00017 ; PF00018 More >>	28.384 (65/229)	6.17E-17
Epithelial discoidin domain receptor 1 (DDR1)	PF00754 ; PF07714	28.279 (69/244)	8.43E-17
Ephrin type-B receptor 2 (EPHB2)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	26.087 (66/253)	9.82E-17
TYRO3 tyrosine kinase receptor (TYRO3)	PF00041 ; PF07679 ; PF07714 More >>	24.691 (60/243)	1.18E-16
Ephrin type-B receptor 3 (EPHB3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	26.316 (60/228)	1.29E-16
Tropomyosin-related kinase A (TrkA)	PF13855 ; PF16920 ; PF07714 ; PF18613 More >>	24.497 (73/298)	1.41E-16
Megakaryocyte-associated tyrosine-protein kinase (MATK)	PF07714 ; PF00017 ; PF00018 More >>	25.781 (66/256)	1.53E-16
Proto-oncogene c-Fer (FER)	PF00611 ; PF07714 ; PF00017 More >>	27.197 (65/239)	1.80E-16
Activated CDC42 kinase 1 (ACK-1)	PF09027 ; PF11555 ; PF07714 ; PF14604 More >>	26.724 (62/232)	1.98E-16
Leukocyte receptor tyrosine kinase (LTK)	PF12810 ; PF07714	26.050 (62/238)	2.04E-16
Tyrosine-protein kinase UFO (AXL)	PF00041 ; PF13927 ; PF07714 More >>	25.532 (60/235)	2.54E-16
Ephrin type-A receptor 5 (EPHA5)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	27.642 (68/246)	2.79E-16
Focal adhesion kinase 2 (PTK2B)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	28.511 (67/235)	3.19E-16
Ephrin type-A receptor 4 (EPHA4)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF07647 More >>	27.119 (64/236)	3.53E-16
Ephrin type-A receptor 7 (EPHA7)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	26.295 (66/251)	5.06E-16
Proto-oncogene c-Fes (FES)	PF07714 ; PF00017	28.821 (66/229)	6.36E-16
Tyrosine-protein kinase Fgr (FGR)	PF07714 ; PF00017 ; PF00018 More >>	26.316 (75/285)	9.81E-16
Discoidin domain-containing receptor 2 (DDR2)	PF00754 ; PF07714	30.493 (68/223)	2.28E-15
Testis-specific kinase 1 (TESK1)	PF07714	27.363 (55/201)	2.87E-15
Insulin receptor (INSR)	PF00757 ; PF17870 ; PF07714 ; PF01030 More >>	23.077 (63/273)	3.84E-15
Tyrosine-protein kinase ZAP-70 (ZAP-70)	PF07714 ; PF00017	26.592 (71/267)	4.05E-15
Ephrin type-A receptor 8 (EPHA8)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	25.957 (61/235)	4.39E-15
Tyrosine-protein kinase SYK (SYK)	PF07714 ; PF00017	28.293 (58/205)	7.19E-15
Janus kinase 1 (JAK-1)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	27.723 (56/202)	1.52E-14
Renal carcinoma antigen NY-REN-64 (IRAK-4)	PF07714	26.699 (55/206)	2.55E-14
Receptor-interacting protein 1 (RIPK1)	PF00531 ; PF07714 ; PF12721 More >>	25.373 (68/268)	3.48E-14
Serine/threonine-protein kinase B-raf (BRAF)	PF00130 ; PF07714 ; PF02196 More >>	23.529 (52/221)	3.54E-14
Serine/threonine-protein kinase A-Raf (ARAF)	PF00130 ; PF07714 ; PF02196 More >>	25.000 (51/204)	5.13E-14
Ephrin type-A receptor 10 (EPHA10)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	26.695 (63/236)	5.16E-14
Proto-oncogene c-RAF (c-RAF)	PF00130 ; PF07714 ; PF02196 More >>	23.288 (51/219)	9.92E-14
Erbb4 tyrosine kinase receptor (Erbb-4)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	26.141 (63/241)	1.03E-13
Macrophage-stimulating protein receptor (RON)	PF07714 ; PF01403 ; PF01833 More >>	28.070 (64/228)	1.08E-13
Insulin-like growth factor I receptor (IGF1R)	PF00757 ; PF07714 ; PF01030 More >>	23.162 (63/272)	1.32E-13
Insulin receptor-related protein (INSRR)	PF00757 ; PF07714 ; PF01030 More >>	21.901 (53/242)	1.32E-13
Erbb2 tyrosine kinase receptor (HER2)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	26.481 (76/287)	1.74E-13
Testis-specific kinase 2 (TESK2)	PF07714	26.154 (51/195)	2.64E-13
Serine/threonine-protein kinase LMTK3 (LMTK3)	PF07714	26.339 (59/224)	3.14E-13
Epidermal growth factor receptor (EGFR)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	26.295 (66/251)	3.36E-13
Non-receptor tyrosine-protein kinase TNK1 (TNK1)	PF07714	27.876 (63/226)	5.00E-13
Serine/threonine-protein kinase LMTK2 (LMTK2)	PF07714	23.529 (64/272)	5.28E-13
Erbb3 tyrosine kinase receptor (Erbb-3)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	28.019 (58/207)	6.99E-13
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1)	PF12796 ; PF13637 ; PF07714 More >>	27.869 (51/183)	8.22E-13
Proto-oncogene c-Met (MET)	PF07714 ; PF01437 ; PF01403 ; PF01833 More >>	26.442 (55/208)	8.59E-13
Proto-oncogene c-Ros (ROS1)	PF00041 ; PF07714	24.242 (64/264)	3.99E-12
Dual serine/threonine and tyrosine protein kinase (DSTYK)	PF07714	27.094 (55/203)	4.81E-12
Ephrin type-B receptor 6 (EPHB6)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF07647 More >>	25.238 (53/210)	9.83E-12
Kinase suppressor of Ras-1 (KSR1)	PF07714 ; PF13543 ; PF20406 More >>	23.913 (55/230)	2.39E-11
Kinase suppressor of Ras 2 (KSR2)	PF07714 ; PF13543 ; PF20406 More >>	23.478 (54/230)	3.47E-11
Ephrin type-A receptor 6 (EPHA6)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	23.827 (66/277)	7.24E-11
Activin receptor-like kinase-1 (ACVRL1)	PF07714 ; PF08515	27.982 (61/218)	9.75E-11
Tyrosine-protein kinase Mer (MERTK)	PF00041 ; PF00047 ; PF07714 More >>	24.186 (52/215)	1.07E-10
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	PF00619 ; PF07714	30.719 (47/153)	2.03E-10
Activin receptor-like kinase 2 (ALK-2)	PF01064 ; PF07714 ; PF08515 More >>	26.540 (56/211)	5.53E-10
Tyrosine-protein kinase STYK1 (STYK1)	PF07714	21.519 (51/237)	5.14E-09
Atrial natriuretic peptide receptor B (NPR2)	PF01094 ; PF00211 ; PF07714 More >>	24.651 (53/215)	1.13E-08
Atrial natriuretic peptide receptor A (NPR1)	PF01094 ; PF00211 ; PF07714 More >>	24.348 (56/230)	3.96E-08
Vascular endothelial growth factor receptor 3 (FLT-4)	PF07679 ; PF13927 ; PF07714 ; PF17988 More >>	35.644 (36/101)	1.18E-07
Retinal guanylyl cyclase 2 (GUCY2F)	PF01094 ; PF00211 ; PF07701 ; PF07714 More >>	26.230 (32/122)	3.51E-07
Vascular endothelial growth factor receptor 1 (FLT-1)	PF07679 ; PF00047 ; PF13927 ; PF07714 ; PF17988 More >>	34.653 (35/101)	6.97E-07
Vascular endothelial growth factor receptor 2 (KDR)	PF07679 ; PF13927 ; PF07714 ; PF17988 More >>	33.333 (33/99)	7.05E-07
Macrophage colony-stimulating factor 1 receptor (CSF1R)	PF00047 ; PF13927 ; PF07714 More >>	27.879 (46/165)	9.90E-07
Bone morphogenetic protein receptor type-1A (BMPR1A)	PF01064 ; PF07714 ; PF08515 More >>	23.767 (53/223)	1.27E-06
Nuclear receptor-binding protein (NRBP1)	PF07714	21.860 (47/215)	2.00E-06
TGF-beta receptor type II (TGFBR2)	PF08917 ; PF07714	22.174 (51/230)	3.32E-06
Platelet-derived growth factor receptor beta (PDGFRB)	PF07679 ; PF00047 ; PF13927 ; PF07714 More >>	31.034 (36/116)	3.65E-06
Platelet-derived growth factor receptor alpha (PDGFRA)	PF07679 ; PF07714	31.731 (33/104)	4.46E-06
Tyrosine-protein kinase RYK (RYK)	PF07714 ; PF02019	22.768 (51/224)	8.60E-06
Bone morphogenetic protein receptor type-1B (BMPR1B)	PF01064 ; PF07714 ; PF08515 More >>	24.545 (54/220)	9.32E-06
Inactive serine/threonine-protein kinase TEX14 (TEX14)	PF12796 ; PF07714	23.158 (44/190)	2.09E-05
Activin receptor type-1C (ACVR1C)	PF01064 ; PF07714 ; PF08515 More >>	27.273 (51/187)	2.29E-05
Tyrosine-protein kinase Kit (KIT)	PF00047 ; PF07714	28.025 (44/157)	1.66E-04
Fms-like tyrosine kinase 3 (FLT-3)	PF00047 ; PF07714	25.000 (29/116)	2.80E-04
Soluble guanylyl cyclase (GUCY2D)	PF01094 ; PF00211 ; PF07701 ; PF07714 More >>	23.529 (32/136)	2.98E-04
Mixed lineage kinase domain-like protein (MLKL)	PF07714	20.652 (38/184)	4.00E-03
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Chemical Structure based Activity Landscape of Target

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References

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REF 1

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.

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