Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T52969
(Former ID: TTDR00281)
|
|||||
| Target Name |
CAP-dependent endonuclease (CDE)
|
|||||
| Gene Name |
NO-GeName
|
|||||
| Target Type |
Discontinued target
|
[1] | ||||
| Disease | [+] 3 Target-related Diseases | + | ||||
| 1 | Colon cancer [ICD-11: 2B90] | |||||
| 2 | Malignant haematopoietic neoplasm [ICD-11: 2B33] | |||||
| 3 | Type 2 diabetes mellitus [ICD-11: 5A11] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Discontinued Drug(s) | [+] 1 Discontinued Drugs | + | ||||
| 1 | GSK184072 | Drug Info | Discontinued in Phase 2 | Type-2 diabetes | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 2 Inhibitor drugs | + | ||||
| 1 | GSK184072 | Drug Info | [1] | |||
| 2 | 4-substituted 2,4-dioxobutanoic acids | Drug Info | [3] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16. | |||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024569) | |||||
| REF 3 | Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrob Agents Chemother. 1996 May;40(5):1304-7. | |||||
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