Target Information
| Target General Information | Top | |||||
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| Target ID |
T52796
(Former ID: TTDR01430)
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| Target Name |
Jagged2 messenger RNA (JAG2 mRNA)
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| Synonyms |
hJ2 (mRNA); Protein jagged-2 (mRNA); Jagged2 (mRNA)
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| Gene Name |
JAG2
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Involved in limb development. Putative Notch ligand involved in the mediation of Notch signaling.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 1 KEGG Pathways | + | ||||
| 1 | Notch signaling pathway | |||||
| Panther Pathway | [+] 2 Panther Pathways | + | ||||
| 1 | Angiogenesis | |||||
| 2 | Notch signaling pathway | |||||
| PID Pathway | [+] 2 PID Pathways | + | ||||
| 1 | Notch signaling pathway | |||||
| 2 | p73 transcription factor network | |||||
| Reactome | [+] 7 Reactome Pathways | + | ||||
| 1 | Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| 2 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| 3 | Constitutive Signaling by NOTCH1 t(7 | |||||
| 4 | M1580_K2555) Translocation Mutant | |||||
| 5 | Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| 6 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| 7 | NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
| WikiPathways | [+] 6 WikiPathways | + | ||||
| 1 | Notch Signaling Pathway | |||||
| 2 | Signaling by NOTCH3 | |||||
| 3 | Signaling by NOTCH4 | |||||
| 4 | Signaling by NOTCH1 | |||||
| 5 | Signaling by NOTCH2 | |||||
| 6 | Notch Signaling Pathway | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 7,425,545, Modulation of C-reactive protein expression. | |||||
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