Target Information
| Target General Information | Top | |||||
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| Target ID |
T49627
(Former ID: TTDR01243)
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| Target Name |
Mycobacterium Cytochrome p450 121 (MycB cyp121)
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| Synonyms |
Cytochrome P450 MT2; Cytochrome P450 121
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| Gene Name |
MycB cyp121
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Catalyzes the formation of an intramolecular C-C bond between two tyrosyl carbon atoms of Cyy.
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| BioChemical Class |
Paired donor oxygen oxidoreductase
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| UniProt ID | ||||||
| EC Number |
EC 1.14.-.-
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| Sequence |
MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWLVSSYALCTQVLEDRRF
SMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPGLEQFLRDTANSL LDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKI NWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGS FLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVR KGELVLVLLEGANFDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIE ALLKKMPGVDLAVPIDQLVWRTRFQRRIPERLPVLW Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: 2-Amino-5-chlorobenzamide | Ligand Info | |||||
| Structure Description | Crystal structure of Mycobacterium tuberculosis CYP121 in complex with LIG9 | PDB:5EDT | ||||
| Method | X-ray diffraction | Resolution | 2.45 Å | Mutation | No | [3] |
| PDB Sequence |
TATVLLEVPF
11 SARGDRIPDA21 VAELRTREPI31 RKVRTITGAE41 AWLVSSYALC51 TQVLEDRRFS 61 MKETAAAGAP71 RLNALTVPPE81 VVNNMGNIAD91 AGLRKAVMKA101 ITPKAPGLEQ 111 FLRDTANSLL121 DNLITEGAPA131 DLRNDFADPL141 ATALHCKVLG151 IPQEDGPKLF 161 RSLSIAFMSS171 ADPIPAAKIN181 WDRDIEYMAG191 ILENPNITTG201 LMGELSRLRK 211 DPAYSHVSDE221 LFATIGVTFF231 GAGVISTGSF241 LTTALISLIQ251 RPQLRNLLHE 261 KPELIPAGVE271 ELLRINLSFA281 DGLPRLATAD291 IQVGDVLVRK301 GELVLVLLEG 311 ANFDPEHFPN321 PGSIELDRPN331 PTSHLAFGRG341 QHFCPGSALG351 RRHAQIGIEA 361 LLKKMPGVDL371 AVPIDQLVWR381 TRFQRRIPER391 LPVLW
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||||
| REF 3 | Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. J Med Chem. 2016 Apr 14;59(7):3272-302. | |||||
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