Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
Cell-based Target Expression Variations
Chemical Structure based Activity Landscape of Target
Target Poor or Non Binders
References
Drug Binding Sites of Target  Top
Ligand Name: Alpha-D-Mannose Ligand Info
Structure Description Co-crystals in the P212121 space group, of a beta-cyclodextrin spacered by triazole heptyl from alpha-D-mannose, with FimH lectin at 2.00 A resolution. PDB:6YHW
Method X-ray diffraction Resolution 1.96 Å Mutation No [9]
PDB Sequence
FACKTANGTA
10
IPIGGGSANV
20
YVNLAPVVNV
30
GQNLVVDLST
40
QIFCHNDYPE
50

TITDYVTLQR
60
GSAYGGVLSN
70
FSGTVKYSGS
80
SYPFPTTSET
90
PRVVYNSRTD
100

KPWPVALYLT
110
PVSSAGGVAI
120
KAGSLIAVLI
130
LRQTNNYNSD
140
DFQFVWNIYA
150

NNDVVVPTG
Residue
Distance (Å)
PHE1
1.880
ILE13
2.151
GLY14
3.170
HIS45
4.275
ASN46
2.264
ASP47
2.103
TYR48
2.282
PRO49
4.765
ILE52
2.432
THR53
4.874
Residue
Distance (Å)
ASP54
1.696
GLN133
2.215
THR134
4.311
ASN135
2.084
TYR137
4.855
ASN138
3.751
ASP140
2.276
PHE142
2.678
PHE144
4.783
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: Edetic acid Ligand Info
Structure Description Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH PDB:5FX3
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [10]
PDB Sequence
FACTANGTAI
11
PIGGGSANVY
21
VNLAPVVNVG
31
QNLVVDLSTQ
41
IFCHNDYPET
51

ITDYVTLQRG
61
SAYGGVLSNF
71
SGTVKYSGSS
81
YPFPTTSETP
91
RVVYNSRTDK
101

PWPVALYLTP
111
VSSAGGVAIK
121
AGSLIAVLIL
131
RQTNNANSDD
141
FQFVWNIYAN
151

NDVVVPT
Residue
Distance (Å)
PRO49
3.684
GLU50
3.838
THR51
3.191
ILE52
3.395
Residue
Distance (Å)
THR53
2.029
ASN136
2.136
ALA137
3.429
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
There is no similarity protein (E value < 0.005) for this target

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