Target Information
| Target General Information | Top | |||||
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| Target ID |
T42882
(Former ID: TTDI01243)
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| Target Name |
Pseudomonas Psl exopolysaccharide (Pseudo pslG)
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| Synonyms |
PslG
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| Gene Name |
Pseudo pslG
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| Target Type |
Clinical trial target
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[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Medical/surgical procedure injury [ICD-11: PK80-PK81] | |||||
| 2 | Glanders [ICD-11: 1B92] | |||||
| Function |
A extracellular matrix component of P. aeruginosa biofilms. A galactose-rich and mannose-rich exopolysaccharide.
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| UniProt ID | ||||||
| Sequence |
MARKGLYLGGSALLLAVVLLLVFWGRPADAEIQVLKAPRAVVWKDFLGVNAQFLWFSPER
YNKQIDRLQDLGLEWVRLDLHWDRLETAEDQYQLASLDQLVKDLEARQLKSVFYLVGSAR FITTAPFYSPFQDQYPPRDPEVFARRMAMLSQRYPSVAAWQVWNEPNLIGFWRPKADPEG YAKLLQASTIALRMVDPEKPVVSAGMAFFSEMPDGRTMFDALGHLGVESLGTIATYHPYT QLPEGNYPWNLDFVSHANQINRALRNAGVPAIWSTEWGWSAYKGPKELQDIIGVEGQADY VLRRLALMSALDYDRIFLFTLSDLDQRASVRDRDYGLLDLDANPKPVYLALQRFLKVTGP KLRPADPPVTEDLPDGSFSIGWTREDGRNVWLFWSARGGNVRLPKLKEATLHDPLSGKVT PLSGSDGLEVPVKSSLQMLVWE Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drugs and Modes of Action | Top | |||||
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| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | MEDI3902 | Drug Info | Phase 2 | Ventilator-associated pneumonia | [2] | |
| References | Top | |||||
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| REF 1 | A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014 Nov 12;6(262):262ra155. | |||||
| REF 2 | ClinicalTrials.gov (NCT02696902) Effort to Prevent Nosocomial Pneumonia Caused by Pseudomonas Aeruginosa in Mechanically Ventilated Subjects | |||||
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