Target Information
| Target General Information | Top | |||||
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| Target ID |
T42004
(Former ID: TTDR01378)
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| Target Name |
Nucleolin messenger RNA (NCL mRNA)
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| Synonyms |
Protein C23 (mRNA); Nucleolin (mRNA)
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| Gene Name |
NCL
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin is the major nucleolar protein of growing eukaryotic cells.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATS
AKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVA TPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAA APASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEE DDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEG TEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDL EKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIR LVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNST WSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEAL NSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARI VTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGR GGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 1 KEGG Pathways | + | ||||
| 1 | Pathogenic Escherichia coli infection | |||||
| NetPath Pathway | [+] 2 NetPath Pathways | + | ||||
| 1 | TCR Signaling Pathway | |||||
| 2 | IL2 Signaling Pathway | |||||
| PID Pathway | [+] 4 PID Pathways | + | ||||
| 1 | Aurora B signaling | |||||
| 2 | Validated targets of C-MYC transcriptional activation | |||||
| 3 | Regulation of Telomerase | |||||
| 4 | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | |||||
| WikiPathways | [+] 5 WikiPathways | + | ||||
| 1 | Pathogenic Escherichia coli infection | |||||
| 2 | miR-targeted genes in squamous cell - TarBase | |||||
| 3 | miR-targeted genes in muscle cell - TarBase | |||||
| 4 | miR-targeted genes in lymphocytes - TarBase | |||||
| 5 | miR-targeted genes in epithelium - TarBase | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,165,786, Antisense modulation of nucleolin expression. | |||||
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