Target Information
| Target General Information | Top | |||||
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| Target ID |
T38093
(Former ID: TTDI02538)
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| Target Name |
Cellular retinol binding protein III (RBP5)
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| Synonyms |
Retinol-binding protein 5; RBP5; HRBPiso; CRBP-III
Click to Show/Hide
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| Gene Name |
RBP5
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Intracellular transport of retinol.
Click to Show/Hide
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| BioChemical Class |
Calycin family
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| UniProt ID | ||||||
| Sequence |
MPPNLTGYYRFVSQKNMEDYLQALNISLAVRKIALLLKPDKEIEHQGNHMTVRTLSTFRN
YTVQFDVGVEFEEDLRSVDGRKCQTIVTWEEEHLVCVQKGEVPNRGWRHWLEGEMLYLEL TARDAVCEQVFRKVR Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Abnormal cannabidiol | Ligand Info | |||||
| Structure Description | Crystal structure of human cellular retinol binding protein 3 in complex with abnormal-cannabidiol (abn-CBD) | PDB:6E5W | ||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [2] |
| PDB Sequence |
PNLTGYYRFV
11 SQKNMEDYLQ21 ALNISLAVRK31 IALLLKPDKE41 IEHQGNHMTV51 RTLSTFRNYT 61 VQFDVGVEFE71 EDLRSVDGRK81 CQTIVTWEEE91 HLVCVQKGEV101 PNRGWRHWLE 111 GEMLYLELTA121 RDAVCEQVFR131 KVR
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PHE10
4.231
GLN13
2.787
MET16
2.302
TYR19
3.483
LEU20
2.530
LEU23
4.988
ILE25
2.101
VAL29
3.007
ALA33
2.183
LEU34
4.491
LEU36
2.350
LYS37
4.678
PRO38
2.805
LYS40
3.268
THR53
2.201
LEU54
4.812
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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| Protein Name | Pfam ID | Percentage of Identity (%) | E value |
|---|---|---|---|
| Fatty acid-binding protein 1 (FABP1) | 24.242 (32/132) | 1.00E-03 |
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| References | Top | |||||
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| REF 1 | Cellular retinol-binding protein type III is a PPARgamma target gene and plays a role in lipid metabolism. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1358-68. | |||||
| REF 2 | Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1. ACS Chem Biol. 2019 Mar 15;14(3):434-448. | |||||
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