Target Information

Target General Information

Target ID

T37384 (Former ID: TTDR00028)

Target Name

Saccharomyces Cell division control protein 28 (Saccha CDC28)

Synonyms

YBR160W; YBR1211; SRM5; HSL5; Cyclindependent kinase 1 of Saccharomyces cerevisiae; Cell division protein kinase 1; Cell division control protein 28; CDK1 of Saccharomyces cerevisiae; CDK1; CDC28

Click to Show/Hide

Gene Name

Saccha CDC28

Target Type

Literature-reported target

[1]

Function

More than 200 substrates have been identified. This protein is essential for the completion of the start, the controlling event, in the cell cycle.

Click to Show/Hide

BioChemical Class

Kinase

UniProt ID

CDK1_YEAST

Sequence

MSGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREIS
LLKELKDDNIVRLYDIVHSDAHKLYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQL
CKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAP
EVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIV
YLPDFKPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQES

Click to Show/Hide

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

Top

Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Janus kinase 2 (JAK-2)	PF18379 ; PF18377 ; PF17887 ; PF07714 ; PF00017 More >>	31.401 (65/207)	5.62E-19
Janus kinase 1 (JAK-1)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	32.195 (66/205)	1.41E-18
Discoidin domain-containing receptor 2 (DDR2)	PF00754 ; PF07714	27.899 (77/276)	6.58E-18
Tyrosine-protein kinase Srms (SRMS)	PF07714 ; PF00017	28.235 (72/255)	1.05E-17
Activated CDC42 kinase 1 (ACK-1)	PF09027 ; PF11555 ; PF07714 ; PF14604 More >>	31.188 (63/202)	3.17E-17
BDNF/NT-3 growth factors receptor (TrkB)	PF07679 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	26.721 (66/247)	4.22E-16
Tyrosine-protein kinase CSK (CSK)	PF07714 ; PF00017 ; PF00018 More >>	28.788 (57/198)	1.08E-15
Insulin receptor-related protein (INSRR)	PF00757 ; PF07714 ; PF01030 More >>	27.619 (58/210)	1.91E-15
Inactive tyrosine-protein kinase 7 (PTK7)	PF07679 ; PF13927 ; PF07714 More >>	25.551 (58/227)	3.06E-15
NT-3 growth factor receptor (TrkC)	PF07679 ; PF00047 ; PF13855 ; PF16920 ; PF01462 ; PF07714 More >>	26.022 (70/269)	3.44E-15
Insulin receptor (INSR)	PF00757 ; PF17870 ; PF07714 ; PF01030 More >>	27.184 (56/206)	5.30E-15
Non-receptor tyrosine-protein kinase TNK1 (TNK1)	PF07714	30.233 (65/215)	6.27E-15
TYK2 tyrosine kinase (TYK2)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	31.220 (64/205)	6.73E-15
Renal carcinoma antigen NY-REN-64 (IRAK-4)	PF07714	30.583 (63/206)	8.71E-15
Tyrosine-protein kinase BRK (PTK6)	PF07714 ; PF00017 ; PF00018 More >>	29.680 (65/219)	1.12E-14
Testis-specific kinase 1 (TESK1)	PF07714	28.019 (58/207)	1.44E-14
LIM domain kinase-2 (LIMK-2)	PF00412 ; PF00595 ; PF07714 More >>	27.982 (61/218)	1.53E-14
Tyrosine-protein kinase FRK (FRK)	PF07714 ; PF00017 ; PF00018 More >>	28.218 (57/202)	1.61E-14
Tropomyosin-related kinase A (TrkA)	PF13855 ; PF16920 ; PF07714 ; PF18613 More >>	27.619 (58/210)	1.82E-14
Fyn tyrosine protein kinase (FYN)	PF07714 ; PF00017 ; PF00018 More >>	25.877 (59/228)	5.87E-14
LIM domain kinase-1 (LIMK-1)	PF00412 ; PF00595 ; PF07714 More >>	25.352 (54/213)	6.05E-14
Tyrosine-protein kinase BMX (BMX)	PF00779 ; PF00169 ; PF07714 ; PF00017 More >>	29.268 (60/205)	6.69E-14
TGF-beta-activated kinase 1 (MAP3K7)	PF07714	32.258 (70/217)	8.18E-14
Megakaryocyte-associated tyrosine-protein kinase (MATK)	PF07714 ; PF00017 ; PF00018 More >>	26.923 (56/208)	8.27E-14
Yes tyrosine kinase (YES)	PF07714 ; PF00017 ; PF00018 More >>	28.502 (59/207)	8.87E-14
Janus kinase 3 (JAK-3)	PF18379 ; PF18377 ; PF17887 ; PF07714 More >>	29.384 (62/211)	1.44E-13
Epithelial discoidin domain receptor 1 (DDR1)	PF00754 ; PF07714	24.609 (63/256)	1.76E-13
Epidermal growth factor receptor (EGFR)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	26.866 (54/201)	1.76E-13
Proto-oncogene c-Src (SRC)	PF07714 ; PF00017 ; PF00018 More >>	26.496 (62/234)	1.77E-13
T-cell-specific kinase (ITK)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	28.431 (58/204)	1.98E-13
B lymphocyte kinase (BLK)	PF07714 ; PF00017 ; PF00018 More >>	26.582 (63/237)	2.13E-13
LCK tyrosine protein kinase (LCK)	PF07714 ; PF00017 ; PF00018 More >>	26.238 (53/202)	2.22E-13
Insulin-like growth factor I receptor (IGF1R)	PF00757 ; PF07714 ; PF01030 More >>	25.980 (53/204)	3.01E-13
Focal adhesion kinase 1 (FAK)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	24.651 (53/215)	3.28E-13
Neurotrophic tyrosine kinase ROR2 (ROR2)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	25.571 (56/219)	3.53E-13
Neurotrophic tyrosine kinase ROR1 (ROR1)	PF01392 ; PF07679 ; PF00051 ; PF07714 More >>	27.027 (60/222)	3.83E-13
MLK-related kinase (MLTK)	PF07714 ; PF00536	27.885 (58/208)	4.01E-13
Titin (TTN)		23.649 (70/296)	4.04E-13
Proto-oncogene c-Fes (FES)	PF07714 ; PF00017	27.519 (71/258)	5.58E-13
Fibroblast growth factor receptor 1 (FGFR1)	PF07679 ; PF00047 ; PF07714 More >>	25.957 (61/235)	5.74E-13
Ephrin type-A receptor 1 (EPHA1)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	25.641 (50/195)	6.96E-13
Muscle-specific kinase receptor (MUSK)	PF01392 ; PF07679 ; PF13927 ; PF07714 More >>	24.000 (54/225)	7.68E-13
Tyrosine-protein kinase Fgr (FGR)	PF07714 ; PF00017 ; PF00018 More >>	28.019 (58/207)	8.25E-13
Tyrosine-protein kinase ABL1 (ABL)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	26.396 (52/197)	2.14E-12
Tyrosine-protein kinase BTK (ATK)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	29.412 (60/204)	2.28E-12
Fibroblast growth factor receptor 2 (FGFR2)	PF07679 ; PF13927 ; PF07714 More >>	26.168 (56/214)	2.48E-12
Tyrosine-protein kinase Tec (PSCTK4)	PF00779 ; PF00169 ; PF07714 ; PF00017 ; PF00018 More >>	26.601 (54/203)	2.92E-12
Tyrosine-protein kinase ZAP-70 (ZAP-70)	PF07714 ; PF00017	27.551 (54/196)	3.38E-12
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12)	PF07714	29.231 (57/195)	4.32E-12
Tyrosine-protein kinase Lyn (JTK8)	PF07714 ; PF00017 ; PF00018 More >>	26.778 (64/239)	7.95E-12
Hematopoietic cell kinase (HCK)	PF07714 ; PF00017 ; PF00018 More >>	26.087 (66/253)	8.00E-12
Macrophage-stimulating protein receptor (RON)	PF07714 ; PF01403 ; PF01833 More >>	25.000 (50/200)	8.14E-12
Mixed lineage kinase 4 (MAP3K21)	PF07714 ; PF14604	28.767 (63/219)	2.86E-11
Fibroblast growth factor receptor 4 (FGFR4)	PF07679 ; PF13927 ; PF07714 More >>	25.207 (61/242)	3.30E-11
Tyrosine-protein kinase TXK (TXK)	PF07714 ; PF00017 ; PF00018 More >>	25.373 (68/268)	3.76E-11
Proto-oncogene c-Fer (FER)	PF00611 ; PF07714 ; PF00017 More >>	28.571 (56/196)	4.29E-11
Erbb4 tyrosine kinase receptor (Erbb-4)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	24.623 (49/199)	4.38E-11
Tyrosine-protein kinase ABL2 (ABL2)	PF08919 ; PF07714 ; PF00017 ; PF00018 More >>	25.381 (50/197)	5.66E-11
Ephrin type-A receptor 2 (EPHA2)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	25.424 (75/295)	8.72E-11
Erbb2 tyrosine kinase receptor (HER2)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	24.631 (50/203)	9.78E-11
Serine/threonine-protein kinase B-raf (BRAF)	PF00130 ; PF07714 ; PF02196 More >>	26.638 (61/229)	1.02E-10
Testis-specific kinase 2 (TESK2)	PF07714	28.641 (59/206)	1.15E-10
Proto-oncogene c-Met (MET)	PF07714 ; PF01437 ; PF01403 ; PF01833 More >>	25.121 (52/207)	1.20E-10
Ephrin type-B receptor 1 (EPHB1)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	24.500 (49/200)	1.56E-10
Mixed lineage kinase 3 (MAP3K11)	PF07714 ; PF14604	29.224 (64/219)	2.55E-10
Tyrosine-protein kinase Mer (MERTK)	PF00041 ; PF00047 ; PF07714 More >>	23.963 (52/217)	2.73E-10
Fibroblast growth factor receptor 3 (FGFR3)	PF07679 ; PF13927 ; PF07714 More >>	24.255 (57/235)	5.58E-10
Tyrosine-protein kinase SYK (SYK)	PF07714 ; PF00017	25.000 (57/228)	7.68E-10
Ephrin type-B receptor 4 (EPHB4)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	23.902 (49/205)	1.22E-09
Focal adhesion kinase 2 (PTK2B)	PF00373 ; PF18038 ; PF03623 ; PF07714 More >>	25.243 (52/206)	1.50E-09
Mitogen-activated protein kinase kinase kinase 13 (MAP3K13)	PF07714	25.128 (49/195)	1.66E-09
Ephrin type-B receptor 3 (EPHB3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	24.757 (51/206)	3.08E-09
Ephrin type-A receptor 3 (EPHA3)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF07647 More >>	25.500 (51/200)	4.25E-09
Serine/threonine-protein kinase LMTK3 (LMTK3)	PF07714	27.064 (59/218)	6.52E-09
Tyrosine-protein kinase UFO (AXL)	PF00041 ; PF13927 ; PF07714 More >>	23.022 (64/278)	6.59E-09
Proto-oncogene c-RAF (c-RAF)	PF00130 ; PF07714 ; PF02196 More >>	24.138 (56/232)	7.10E-09
Ephrin type-A receptor 4 (EPHA4)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF07647 More >>	25.592 (54/211)	1.00E-08
Kinase suppressor of Ras 2 (KSR2)	PF07714 ; PF13543 ; PF20406 More >>	25.234 (54/214)	1.02E-08
Serine/threonine-protein kinase TNNI3K (TNNI3K)	PF12796 ; PF13637 ; PF07714 More >>	23.558 (49/208)	1.15E-08
Ephrin type-A receptor 5 (EPHA5)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	26.000 (52/200)	1.31E-08
Leukocyte receptor tyrosine kinase (LTK)	PF12810 ; PF07714	25.822 (55/213)	1.44E-08
Mixed lineage kinase 2 (MAP3K10)	PF07714 ; PF14604	30.769 (64/208)	1.54E-08
Proto-oncogene c-Ros (ROS1)	PF00041 ; PF07714	28.019 (58/207)	1.58E-08
Receptor-interacting protein 1 (RIPK1)	PF00531 ; PF07714 ; PF12721 More >>	22.727 (55/242)	2.41E-08
Erbb3 tyrosine kinase receptor (Erbb-3)	PF00757 ; PF14843 ; PF07714 ; PF01030 More >>	25.000 (51/204)	2.92E-08
Proto-oncogene c-Ret (RET)	PF00028 ; PF07714 ; PF17756 ; PF17812 ; PF17813 More >>	24.434 (54/221)	3.54E-08
Bone morphogenetic protein receptor type-1A (BMPR1A)	PF01064 ; PF07714 ; PF08515 More >>	25.649 (79/308)	3.98E-08
Ephrin type-A receptor 8 (EPHA8)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	26.141 (63/241)	5.49E-08
Vascular endothelial growth factor receptor 1 (FLT-1)	PF07679 ; PF00047 ; PF13927 ; PF07714 ; PF17988 More >>	23.913 (44/184)	7.02E-08
Ephrin type-A receptor 7 (EPHA7)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	25.359 (53/209)	7.11E-08
Kinase suppressor of Ras-1 (KSR1)	PF07714 ; PF13543 ; PF20406 More >>	22.642 (48/212)	1.04E-07
Bone morphogenetic protein receptor type-1B (BMPR1B)	PF01064 ; PF07714 ; PF08515 More >>	24.585 (74/301)	1.92E-07
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1)	PF12796 ; PF13637 ; PF07714 More >>	23.830 (56/235)	2.43E-07
Ephrin type-B receptor 2 (EPHB2)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	22.222 (44/198)	3.60E-07
Vascular endothelial growth factor receptor 3 (FLT-4)	PF07679 ; PF13927 ; PF07714 ; PF17988 More >>	31.373 (32/102)	3.65E-07
Angiopoietin 1 receptor (TEK)	PF00041 ; PF10430 ; PF07714 More >>	25.243 (52/206)	4.01E-07
Ephrin type-A receptor 6 (EPHA6)	PF14575 ; PF01404 ; PF07699 ; PF00041 ; PF07714 ; PF00536 More >>	23.105 (64/277)	4.06E-07
Serine/threonine-protein kinase A-Raf (ARAF)	PF00130 ; PF07714 ; PF02196 More >>	23.043 (53/230)	4.38E-07
Dual serine/threonine and tyrosine protein kinase (DSTYK)	PF07714	23.571 (66/280)	4.47E-07
Tie-1 tyrosine kinase receptor (TIE1)	PF00041 ; PF00047 ; PF07714 More >>	25.121 (52/207)	7.38E-07
TGF-beta receptor type II (TGFBR2)	PF08917 ; PF07714	26.606 (58/218)	3.03E-06
Activin receptor-like kinase 2 (ALK-2)	PF01064 ; PF07714 ; PF08515 More >>	27.602 (61/221)	3.87E-06
Serine/threonine-protein kinase LMTK2 (LMTK2)	PF07714	28.481 (45/158)	4.08E-06
Serine/threonine-protein kinase LMTK1 (AATK)	PF07714	23.810 (50/210)	4.49E-06
Vascular endothelial growth factor receptor 2 (KDR)	PF07679 ; PF13927 ; PF07714 ; PF17988 More >>	31.183 (29/93)	4.85E-06
TYRO3 tyrosine kinase receptor (TYRO3)	PF00041 ; PF07679 ; PF07714 More >>	24.880 (52/209)	5.61E-06
Platelet-derived growth factor receptor beta (PDGFRB)	PF07679 ; PF00047 ; PF13927 ; PF07714 More >>	31.579 (30/95)	1.16E-05
ALK tyrosine kinase receptor (ALK)	PF12810 ; PF00629 ; PF07714 More >>	22.967 (48/209)	1.65E-05
Platelet-derived growth factor receptor alpha (PDGFRA)	PF07679 ; PF07714	29.348 (27/92)	3.77E-05
Macrophage colony-stimulating factor 1 receptor (CSF1R)	PF00047 ; PF13927 ; PF07714 More >>	30.208 (29/96)	1.18E-04
Tyrosine-protein kinase Kit (KIT)	PF00047 ; PF07714	30.208 (29/96)	1.21E-04
Fms-like tyrosine kinase 3 (FLT-3)	PF00047 ; PF07714	30.208 (29/96)	1.23E-04
Atrial natriuretic peptide receptor B (NPR2)	PF01094 ; PF00211 ; PF07714 More >>	34.343 (34/99)	1.39E-04
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	PF00619 ; PF07714	26.496 (31/117)	3.60E-04
Mixed lineage kinase domain-like protein (MLKL)	PF07714	24.309 (44/181)	4.63E-04
Nuclear receptor-binding protein (NRBP1)	PF07714	22.449 (55/245)	8.62E-04
Tyrosine-protein kinase RYK (RYK)	PF07714 ; PF02019	18.408 (37/201)	1.00E-03
Ephrin type-A receptor 10 (EPHA10)	PF14575 ; PF01404 ; PF00041 ; PF07714 ; PF00536 More >>	25.500 (51/200)	2.00E-03
Retinal guanylyl cyclase 2 (GUCY2F)	PF01094 ; PF00211 ; PF07701 ; PF07714 More >>	26.486 (49/185)	3.00E-03
Atrial natriuretic peptide receptor A (NPR1)	PF01094 ; PF00211 ; PF07714 More >>	21.461 (47/219)	5.00E-03
Click to Show/Hide the Information of Human Similarity Proteins

Chemical Structure based Activity Landscape of Target

Top

Target Poor or Non Binders

Top

Target Poor or Non Binders

Target Poor or Non Binders Info

References

Top

REF 1

Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. J Antibiot (Tokyo). 2001 Jan;54(1):84-90.

REF 2

Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J Antibiot (Tokyo). 1997 Aug;50(8):671-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Prof. Feng ZHU

Prof. Yuzong CHEN