Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T36658
(Former ID: TTDI01201)
|
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| Target Name |
Oxidative stress (OS)
|
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| Gene Name |
NO-GeName
|
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| Target Type |
Clinical trial target
|
[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Cerebral ischaemic stroke [ICD-11: 8B11] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | SUN-N8075 | Drug Info | Phase 1 | Cerebral infarction | [1], [2] | |
| Discontinued Drug(s) | [+] 1 Discontinued Drugs | + | ||||
| 1 | AC3056 | Drug Info | Discontinued in Phase 1 | Arteriosclerosis | [3] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 2 Inhibitor drugs | + | ||||
| 1 | SUN-N8075 | Drug Info | [1], [2] | |||
| 2 | AC3056 | Drug Info | [4] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice. Biol Pharm Bull. 2014;37(3):424-30. | |||||
| REF 2 | SUN N8075, a novel radical scavenger, protects against retinal cell death in mice. Neurosci Lett. 2011 Jan 13;488(1):87-91. | |||||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012486) | |||||
| REF 4 | The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men. J Sex Med. 2009 Feb;6(2):373-87. | |||||
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