Target Information

Target General Information

Target ID

T30926 (Former ID: TTDI02247)

Target Name

GRB2 messenger RNA (GRB2 mRNA)

Synonyms

SH2/SH3 adapter GRB2 (mRNA); Protein Ash (mRNA); Growth factor receptor-bound protein 2 (mRNA); Adapter protein GRB2 (mRNA); ASH (mRNA)

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Gene Name

GRB2

Target Type

Clinical trial target

[1]

Disease

[+] 5 Target-related Diseases

Acute myeloid leukaemia [ICD-11: 2A60]

Malignant haematopoietic neoplasm [ICD-11: 2B33]

Mature B-cell lymphoma [ICD-11: 2A85]

Myelodysplastic syndrome [ICD-11: 2A37]

Myeloproliferative neoplasm [ICD-11: 2A20]

Function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.

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BioChemical Class

mRNA target

UniProt ID

GRB2_HUMAN

Sequence

MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

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Drugs and Modes of Action

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Clinical Trial Drug(s)

[+] 1 Clinical Trial Drugs

BP-100-1-01

Drug Info

Phase 2

Myelodysplastic syndrome

[2]

Mode of Action

[+] 1 Modes of Action

Modulator

[+] 1 Modulator drugs

BP-100-1-01

Drug Info

[1], [3]

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Target Profiles in Patients

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Target Expression
Profile (TEP)

Target Expression Profile Info

Target Affiliated Biological Pathways		Top
NetPath Pathway	[+] 1 NetPath Pathways	+
1	EGFR1 Signaling Pathway
PID Pathway	[+] 45 PID Pathways	+
1	Fc-epsilon receptor I signaling in mast cells
2	BCR signaling pathway
3	ErbB4 signaling events
4	Insulin Pathway
5	GMCSF-mediated signaling events
6	IL4-mediated signaling events
7	TCR signaling in na&#xef
8
9	Plasma membrane estrogen receptor signaling
10	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
11	Signaling events mediated by PTP1B
12	EPHB forward signaling
13	Signaling events regulated by Ret tyrosine kinase
14	TCR signaling in na&#xef
15
16	Signaling events mediated by TCPTP
17	Angiopoietin receptor Tie2-mediated signaling
18	SHP2 signaling
19	IL2-mediated signaling events
20	IGF1 pathway
21	EGF receptor (ErbB1) signaling pathway
22	IL5-mediated signaling events
23	EGFR-dependent Endothelin signaling events
24	IL2 signaling events mediated by PI3K
25	ErbB1 downstream signaling
26	ErbB2/ErbB3 signaling events
27	IL3-mediated signaling events
28	IL6-mediated signaling events
29	PDGFR-beta signaling pathway
30	Neurotrophic factor-mediated Trk receptor signaling
31	Nephrin/Neph1 signaling in the kidney podocyte
32	PDGFR-alpha signaling pathway
33	Internalization of ErbB1
34	Signaling events mediated by Stem cell factor receptor (c-Kit)
35	EPO signaling pathway
36	IL2 signaling events mediated by STAT5
37	Signaling events mediated by VEGFR1 and VEGFR2
38	a6b1 and a6b4 Integrin signaling
39	Regulation of Ras family activation
40	Trk receptor signaling mediated by PI3K and PLC-gamma
41	EPHA2 forward signaling
42	VEGFR3 signaling in lymphatic endothelium
43	FGF signaling pathway
44	Signaling events mediated by focal adhesion kinase
45	TGF-beta receptor signaling

References

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REF 1

ClinicalTrials.gov (NCT01159028) Clinical Trial of BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDS. U.S. National Institutes of Health.

REF 2

Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032443)

REF 3

Liposomal delivery of nucleic acid-based anticancer therapeutics: BP-100-1.01. Expert Opin Drug Deliv. 2015 Jul;12(7):1107-20.

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