Target Information

Target General Information

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Target ID

T30292 (Former ID: TTDR00769)

Target Name

Virus Cysteine proteinase (Viru VCATH)

Synonyms

Viral cathepsin; VCATH; V-cath; CP of Cydia pomonella granulosis virus

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Gene Name

Viru VCATH

Target Type

Literature-reported target

[1]

Function

Cysteine protease that plays an essential role in host liquefactionto facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system.

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BioChemical Class

Peptidase

UniProt ID

CATV_GVCPM

EC Number

EC 3.4.22.50

Sequence

MTKLLNFVILASVLTVTAHALTYDLNNSDELFKNFAIKYNKTYVSDEERAIKLENFKNNL
KMINEKNMASKYAVFDINEYSDLNKNALLRRTTGFRLGLKKNPSAFTMTECSVVVIKDEP
QALLPETLDWRDKHGVTPVKNQMECGSCWAFSTIANIESLYNIKYDKALNLSEQHLVNCD
NINNGCAGGLMHWALESILQEGGVVSAENEPYYGFDGVCKKSPFELSISGSRRYVLQNEN
KLRELLVVNGPISVAIDVSDLINYKAGIADICENNEGLNHAVLLVGYGVKNDVPYWILKN
SWGAEWGEEGYFRVQRDKNSCGMMNEYASSAIL

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Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

There is no similarity protein (E value < 0.005) for this target

References

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REF 1

Characterization of a cysteine proteinase from Taenia crassiceps cysts. Mol Biochem Parasitol. 1997 Apr;85(2):243-53.

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