Target Information

Target General Information

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Target ID

T22368 (Former ID: TTDI02451)

Target Name

Nel-related protein 1 (NELL1)

Synonyms

NELL1; NEL-like protein 1

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Gene Name

NELL1

Target Type

Literature-reported target

[1]

Function

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

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UniProt ID

NELL1_HUMAN

Sequence

MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLF
QDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSG
LRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT
NLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGI
MDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSG
AVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGV
LVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKS
GYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDEC
GSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSG
FTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDEC
ALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCK
DGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLE
GEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSV
WTMAGSPCTTCKCKNGRVCCSVDFECLQNN

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3D Structure

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AlphaFold

Cell-based Target Expression Variations

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Cell-based Target Expression Variations

Cell-based Target Expression Variations Info

Different Human System Profiles of Target	Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target. A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020). Human Similarity Proteins

Different Human System Profiles of Target

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Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.

A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).

Human Similarity Proteins

Protein Name	Pfam ID	Percentage of Identity (%)	E value
Delta-like protein 1 (DLL1)	PF01414 ; PF00008 ; PF12661 ; PF07657 More >>	34.783 (72/207)	8.56E-14
Delta-like protein 4 (DLL4)	PF01414 ; PF00008 ; PF07657 More >>	32.850 (68/207)	2.92E-12
Collagen alpha-1(XI) chain (COL11A1)	PF01410 ; PF01391	24.765 (79/319)	1.31E-10
Delta-like protein 3 (DLL3)	PF00008 ; PF12661 ; PF07657 More >>	34.211 (52/152)	6.61E-10
Slit homolog 2 protein (SLIT2)	PF00008 ; PF12661 ; PF00054 ; PF13855 ; PF01463 ; PF01462 More >>	32.117 (44/137)	1.02E-09
Delta and Notch-like epidermal growth factor-related receptor (DNER)	PF19330 ; PF00008 ; PF12661 More >>	29.798 (59/198)	1.30E-09
Sushi, nidogen and EGF-like domain-containing protein 1 (SNED1)	PF00008 ; PF00041 ; PF12661 ; PF06119 More >>	29.915 (70/234)	1.61E-09
Matrilin-4 (MATN4)	PF12662 ; PF14670 ; PF10393 ; PF00092 More >>	32.609 (60/184)	8.04E-09
Collagen alpha-1(V) chain (COL5A1)	PF01410 ; PF01391	25.641 (40/156)	1.86E-08
Protein delta homolog 2 (DLK2)	PF00008 ; PF12661	32.530 (54/166)	5.97E-07
von Willebrand factor D and EGF domain-containing protein (VWDE)	PF00094	31.544 (47/149)	1.01E-06
Hedgehog-interacting protein (HHIP)	PF03024 ; PF07995	47.541 (29/61)	1.21E-06
Protein delta homolog 1 (DLK1)	PF00008	27.778 (45/162)	1.24E-06
Matrilin-3 (MATN3)	PF14670 ; PF10393 ; PF00092 More >>	34.694 (34/98)	2.11E-05
Versican core protein (VCAN)	PF00008 ; PF00059 ; PF00084 ; PF07686 ; PF00193 More >>	33.766 (26/77)	2.19E-05
Wnt inhibitory factor 1 (WIF1)	PF12661 ; PF02019	26.471 (54/204)	1.61E-04
Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSPEAR)	PF03736	29.630 (32/108)	7.62E-04
Cryptic protein (CFC1)	PF09443	45.098 (23/51)	1.00E-03
Cryptic family protein 1B (CFC1B)	PF09443	45.098 (23/51)	1.00E-03
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)	PF00008 ; PF00754 ; PF12661 More >>	30.303 (40/132)	2.00E-03
Tie-1 tyrosine kinase receptor (TIE1)	PF00041 ; PF00047 ; PF07714 More >>	44.828 (26/58)	5.00E-03
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References

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REF 1

Combining Smoothened Agonist and NEL-Like Protein-1 Enhances Bone Healing. Plast Reconstr Surg. 2017 Jun;139(6):1385-1396.

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