Target Information
Target General Information | Top | |||||
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Target ID |
T18779
(Former ID: TTDR00730)
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Target Name |
Mucin-1 (MUC1)
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Synonyms |
Tumour-associated antigen mucin 1; Tumor-associated mucin; Tumor-associated epithelial membraneantigen; Tumor-associated epithelial membrane antigen; Polymorphic epithelial mucin; Peanut-reactive urinary mucin; PUM; PEMT; PEM; MUC-1; Krebs von den Lungen-6; KL-6; H23AG; Episialin; EMA; Carcinoma-associated mucin; Cancer antigen 15-3; CD227 antigen; CD227; CA 15-3; Breast carcinoma-associated antigen DF3
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Gene Name |
MUC1
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Target Type |
Clinical trial target
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[1] | ||||
Disease | [+] 3 Target-related Diseases | + | ||||
1 | Pancreatic cancer [ICD-11: 2C10] | |||||
2 | Bipolar disorder [ICD-11: 6A60] | |||||
3 | Lung cancer [ICD-11: 2C25] | |||||
Function |
Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The alpha subunit has cell adhesive properties.
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UniProt ID | ||||||
Sequence |
MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSV
LSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTS APDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTS ASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHS SVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQI YKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVS VSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPAR DTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL Click to Show/Hide
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3D Structure | Click to Show 3D Structure of This Target | AlphaFold | ||||
HIT2.0 ID | T36S9V |
Drugs and Modes of Action | Top | |||||
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Clinical Trial Drug(s) | [+] 28 Clinical Trial Drugs | + | ||||
1 | Yttrium (90Y) clivatuzumab tetraxetan | Drug Info | Phase 3 | Pancreatic cancer | [2], [3] | |
2 | TG-4010 | Drug Info | Phase 2/3 | Bipolar disorder | [4] | |
3 | AS-1402 | Drug Info | Phase 2 | Breast cancer | [5] | |
4 | Emepepimut-S | Drug Info | Phase 2 | Non-small-cell lung cancer | [6] | |
5 | GO-203-2c | Drug Info | Phase 2 | Acute myeloid leukaemia | [7] | |
6 | ICO-25 | Drug Info | Phase 2 | Breast cancer | [8] | |
7 | MUC1-Poly-ICLC | Drug Info | Phase 2 | Colorectal cancer | [9] | |
8 | Pankomab-GEX | Drug Info | Phase 2 | Solid tumour/cancer | [10] | |
9 | SAR-566658 | Drug Info | Phase 2 | Triple negative breast cancer | [7] | |
10 | Anti-MUC1 CAR T Cells | Drug Info | Phase 1/2 | Breast cancer | [11] | |
11 | Anti-MUC1 CAR T Cells | Drug Info | Phase 1/2 | Lung cancer | [12] | |
12 | Anti-MUC1 CAR-T cells | Drug Info | Phase 1/2 | Colorectal cancer | [13] | |
13 | Anti-MUC1 CAR-T cells | Drug Info | Phase 1/2 | Esophageal cancer | [14] | |
14 | BrevaRex | Drug Info | Phase 1/2 | Pancreatic cancer | [15] | |
15 | CAR-T cells targeting Muc1 | Drug Info | Phase 1/2 | Cervical cancer | [16] | |
16 | CAR-T cells targeting MucI | Drug Info | Phase 1/2 | Lung cancer | [17] | |
17 | G0-203-2c | Drug Info | Phase 1/2 | Pancreatic cancer | [18] | |
18 | ImMucin | Drug Info | Phase 1/2 | Multiple myeloma | [19] | |
19 | MUC-1 CART cell immunotherapy | Drug Info | Phase 1/2 | Intrahepatic cholangiocarcinoma | [20] | |
20 | Muc1-specific gene-engineered T cells | Drug Info | Phase 1/2 | Acute myeloid leukaemia | [21] | |
21 | Anti-MUC1 mab | Drug Info | Phase 1 | Pancreatic cancer | [22] | |
22 | CAR-T cells targeting MUC1 | Drug Info | Phase 1 | Solid tumour/cancer | [23] | |
23 | CAR-T Cells targeting MUCI | Drug Info | Phase 1 | Pancreatic cancer | [24] | |
24 | CART-Muc1 cells | Drug Info | Phase 1 | Myelodysplastic syndrome | [25] | |
25 | HuMNC2-CAR44 T cells | Drug Info | Phase 1 | Breast cancer | [26] | |
26 | MUC-1 dendritic cancer vaccine | Drug Info | Phase 1 | Solid tumour/cancer | [27] | |
27 | ONT-10 | Drug Info | Phase 1 | Solid tumour/cancer | [28] | |
28 | TnMUC-1 CAR-T cell therapy | Drug Info | Phase 1 | Solid tumour/cancer | [29] | |
Preclinical Drug(s) | [+] 1 Preclinical Drugs | + | ||||
1 | CAR-T cells targeting Mucl | Drug Info | Preclinical | Acute myeloid leukaemia | [30] | |
Mode of Action | [+] 3 Modes of Action | + | ||||
Modulator | [+] 4 Modulator drugs | + | ||||
1 | TG-4010 | Drug Info | [4] | |||
2 | G0-203-2c | Drug Info | [32] | |||
3 | Anti-MUC1 mab | Drug Info | [40] | |||
4 | TG-1031 | Drug Info | [44] | |||
Inhibitor | [+] 2 Inhibitor drugs | + | ||||
1 | GO-203-2c | Drug Info | [32] | |||
2 | TnMUC-1 CAR-T cell therapy | Drug Info | [29] | |||
CAR-T-Cell-Therapy | [+] 12 CAR-T-Cell-Therapy drugs | + | ||||
1 | Anti-MUC1 CAR T Cells | Drug Info | [11] | |||
2 | Anti-MUC1 CAR T Cells | Drug Info | [12] | |||
3 | Anti-MUC1 CAR-T cells | Drug Info | [13] | |||
4 | Anti-MUC1 CAR-T cells | Drug Info | [14] | |||
5 | CAR-T cells targeting Muc1 | Drug Info | [16] | |||
6 | CAR-T cells targeting MucI | Drug Info | [17], [38] | |||
7 | MUC-1 CART cell immunotherapy | Drug Info | [20] | |||
8 | Muc1-specific gene-engineered T cells | Drug Info | [21] | |||
9 | CAR-T cells targeting MUC1 | Drug Info | [23] | |||
10 | CAR-T Cells targeting MUCI | Drug Info | [24] | |||
11 | CART-Muc1 cells | Drug Info | [25] | |||
12 | CAR-T cells targeting Mucl | Drug Info | [30] |
Cell-based Target Expression Variations | Top | |||||
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Cell-based Target Expression Variations |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: N-Acetyl-2-deoxy-2-amino-galactose | Ligand Info | |||||
Structure Description | Crystal structure of SN-101 mAb in complex with MUC1 glycopeptide | PDB:6KX1 | ||||
Method | X-ray diffraction | Resolution | 1.77 Å | Mutation | No | [45] |
PDB Sequence |
VTSAPDTRPA
10
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: N-Acetyl-beta-D-galactosamine | Ligand Info | |||||
Structure Description | Crystal structure of Antibody 16A in complex with MUC1 Glycopeptide(GlycoT) | PDB:7V64 | ||||
Method | X-ray diffraction | Resolution | 1.56 Å | Mutation | No | [46] |
PDB Sequence |
STAPPAHG
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Click to View More Binding Site Information of This Target with Different Ligands |
Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors
of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information
(Front Pharmacol, 9, 1245, 2018;
Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
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Protein Name | Pfam ID | Percentage of Identity (%) | E value |
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Small proline-rich protein 3 (SPRR3) | 34.615 (45/130) | 1.08E-05 |
Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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Degree | 28 | Degree centrality | 3.01E-03 | Betweenness centrality | 7.28E-03 |
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Closeness centrality | 2.58E-01 | Radiality | 1.45E+01 | Clustering coefficient | 2.46E-01 |
Neighborhood connectivity | 5.01E+01 | Topological coefficient | 5.96E-02 | Eccentricity | 12 |
Download | Click to Download the Full PPI Network of This Target | ||||
Target Regulators | Top | |||||
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Target-regulating microRNAs | ||||||
Target-interacting Proteins |
Target Profiles in Patients | Top | |||||
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Target Expression Profile (TEP) |
Target Affiliated Biological Pathways | Top | |||||
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WikiPathways | [+] 1 WikiPathways | + | ||||
1 | Hematopoietic Stem Cell Differentiation |
References | Top | |||||
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REF 1 | Clinical pipeline report, company report or official report of Immunomedics. | |||||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8087). | |||||
REF 3 | ClinicalTrials.gov (NCT01956812) Phase 3 Trial of 90Y-Clivatuzumab Tetraxetan & Gemcitabine vs Placebo & Gemcitabine in Metastatic Pancreatic Cancer. U.S. National Institutes of Health. | |||||
REF 4 | A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol. 2008 Jul;3(7):735-44. | |||||
REF 5 | Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer. Breast Cancer Res. 2009;11(5):R73. | |||||
REF 6 | ClinicalTrials.gov (NCT00828009) BLP25 Liposome Vaccine and Bevacizumab After Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Stage IIIA or Stage IIIB Non-Small Cell LungCancer That Cannot Be Removed by Surgery. U.S. National Institutes of Health. | |||||
REF 7 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
REF 8 | Atemonate and Imuteran: novel Russian monoclonal antibody-based therapeutic agents. Biotechnol J. 2007 Jul;2(7):863-70. | |||||
REF 9 | ClinicalTrials.gov (NCT00773097) Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma. U.S. National Institutes of Health. | |||||
REF 10 | ClinicalTrials.gov (NCT01899599) PankoMab-GEX Versus Placebo as Maintenance Therapy in Advanced Ovarian Cancer. U.S. National Institutes of Health. | |||||
REF 11 | ClinicalTrials.gov (NCT02587689) Phase I/II Study of Anti-Mucin1 (MUC1) CAR T Cells for Patients With MUC1+ Advanced Refractory Solid Tumor | |||||
REF 12 | ClinicalTrials.gov (NCT03525782) Anti-MUC1 CAR T Cells and PD-1 Knockout Engineered T Cells for NSCLC | |||||
REF 13 | ClinicalTrials.gov (NCT02617134) CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor | |||||
REF 14 | ClinicalTrials.gov (NCT03706326) CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer | |||||
REF 15 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010209) | |||||
REF 16 | ClinicalTrials.gov (NCT03356795) Intervention of CAR-T Against Cervical Cancer | |||||
REF 17 | ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer | |||||
REF 18 | ClinicalTrials.gov (NCT02204085) A Phase I/II Trial of the MUC1 Inhibitor, GO-203-2C in Patients With Relapsed or Refractory Acute Myeloid Leukemia. U.S. National Institutes of Health. | |||||
REF 19 | ClinicalTrials.gov (NCT01232712) A Study to Assess the Safety and Efficacy of MUC1 Peptide Vaccine and hGM-CSF in Patients With MUC1-positive Tumor Malignancies. U.S. National Institutes of Health. | |||||
REF 20 | ClinicalTrials.gov (NCT03633773) Safety and Efficacy Evaluation of MUC-1 CART in the Treatment of Intrahepatic Cholangiocarcinoma | |||||
REF 21 | ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia | |||||
REF 22 | Clinical pipeline report, company report or official report of Quest PharmaTech. | |||||
REF 23 | ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers | |||||
REF 24 | ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. | |||||
REF 25 | ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS | |||||
REF 26 | ClinicalTrials.gov (NCT04020575) Autologous huMNC2-CAR44 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*). U.S. National Institutes of Health. | |||||
REF 27 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041064) | |||||
REF 28 | ClinicalTrials.gov (NCT01556789) Phase 1 Study of ONT-10 in Patients With Solid Tumors. U.S. National Institutes of Health. | |||||
REF 29 | ClinicalTrials.gov (NCT04025216) A Study of CART-TnMUC1 in Patients With TnMUC1-Positive Advanced Cancers. U.S. National Institutes of Health. | |||||
REF 30 | ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia | |||||
REF 31 | Emepepimut-S for non-small cell lung cancer. Expert Opin Biol Ther. 2011 Aug;11(8):1091-7. | |||||
REF 32 | Clinical pipeline report, company report or official report of Genus Oncology. | |||||
REF 33 | The role of epithelial antigens in diagnosis and staging of breast cancer. Arkh Patol. 2002 Nov-Dec;64(6):13-5. | |||||
REF 34 | Early in vivo signaling profiles in MUC1-specific CD4+ T cells responding to two different MUC1-targeting vaccines in two different microenvironments. Oncoimmunology. 2013 Mar 1;2(3):e23429. | |||||
REF 35 | Staining of MUC1 in ovarian cancer tissues with PankoMab-GEX detecting the tumour-associated epitope, TA-MUC1, as compared to antibodies HMFG-1 and 115D8. Histol Histopathol. 2013 Feb;28(2):239-44. | |||||
REF 36 | Integrating in vitro signaling and drug response data from single cell network profiling (SCNP) to inform on individual's AML biology.Molecular Cancer Therapeutics. 11/2011; 10(Supplement 1):A73-A73. | |||||
REF 37 | Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity. Ann Oncol. 2004 Dec;15(12):1825-33. | |||||
REF 38 | ClinicalTrials.gov (NCT03170141) Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme | |||||
REF 39 | Phase I/II study exploring ImMucin, a pan-major histocompatibility complex, anti-MUC1 signal peptide vaccine, in multiple myeloma patients. Br J Haematol. 2015 Apr;169(1):44-56. | |||||
REF 40 | Characterization of an anti-MUC1 monoclonal antibody with potential as a cancer vaccine. Hybrid Hybridomics. 2001;20(5-6):313-24. | |||||
REF 41 | Clinical pipeline report, company report or official report of Minerva Biotechnologies. | |||||
REF 42 | Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin. Int J Mol Med. 2003 Oct;12(4):493-502. | |||||
REF 43 | Clinical pipeline report, company report or official report of Oncothyreon. | |||||
REF 44 | Technology evaluation: TG-1031, Transgene SA.Curr Opin Mol Ther.2000 Feb;2(1):106-11. | |||||
REF 45 | A straightforward approach to antibodies recognising cancer specific glycopeptidic neoepitopes. doi:10.1039/D0SC00317D. | |||||
REF 46 | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding |
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