Target Information
| Target General Information | Top | |||||
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| Target ID |
T17291
(Former ID: TTDI03028)
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| Target Name |
Ammonium transporter Rh type C (RHCG)
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| Synonyms |
Tumor-related protein DRC2; Rhesus blood group family type C glycoprotein; Rh type C glycoprotein; Rh glycoprotein kidney; Rh family type C glycoprotein; RHGK; PDRC2; CDRC2; C15orf6
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| Gene Name |
RHCG
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
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| UniProt ID | ||||||
| Sequence |
MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRY
PSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVV GVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGG SMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAIS YHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMM LMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAA SASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPF WGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: B-Octylglucoside | Ligand Info | |||||
| Structure Description | Crystal Structure of the Human Rhesus Glycoprotein RhCG | PDB:3HD6 | ||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [2] |
| PDB Sequence |
SAWNTNLRWR
10 LPLTCLLLQV20 IMVILFGVFV30 RYDFENEFYY58 RYPSFQDVHV68 MVFVGFGFLM 78 TFLQRYGFSA88 VGFNFLLAAF98 GIQWALLMQG108 WFHFLQDRYI118 VVGVENLINA 128 DFCVASVCVA138 FGAVLGKVSP148 IQLLIMTFFQ158 VTLFAVNEFI168 LLNLLKVKDA 178 GGSMTIHTFG188 AYFGLTVTRI198 LYRRNLEQSK208 ERQNSVYQSD218 LFAMIGTLFL 228 WMYWPSFNSA238 ISYHGDSQHR248 AAINTYCSLA258 ACVLTSVAIS268 SALHKKGKLD 278 MVHIQNATLA288 GGVAVGTAAE298 MMLMPYGALI308 IGFVCGIIST318 LGFVYLTPFL 328 ESRLHIQDTC338 GINNLHGIPG348 IIGGIVGAVT358 AASDWTARTQ390 GKFQIYGLLV 400 TLAMALMGGI410 IVGLILRLPF420 WGQPSDENCF430 EDAVYWEMPE440 GNS |
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| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Human Similarity Proteins
Human Tissue Distribution
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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| References | Top | |||||
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| REF 1 | Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG. Am J Physiol Renal Physiol. 2006 Feb;290(2):F297-305. | |||||
| REF 2 | Function of human Rh based on structure of RhCG at 2.1 A. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9638-43. | |||||
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