Target Information
| Target General Information | Top | |||||
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| Target ID |
T15494
(Former ID: TTDC00345)
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| Target Name |
GHR messenger RNA (GHR mRNA)
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| Synonyms |
Somatotropin receptor (mRNA); Serum bindingprotein (mRNA); Growth hormone receptor (mRNA); GH receptor (mRNA)
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| Gene Name |
GHR
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| Target Type |
Clinical trial target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Pituitary gland disorder [ICD-11: 5A60-5A61] | |||||
| Function |
On ligand binding, couples to the JAK2/STAT5 pathway. Receptor for pituitary gland growth hormone involved in regulating postnatal body growth.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| Sequence |
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPE
RETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTS IWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRN ADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNY GEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPP VPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEES DTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGE ADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSS LSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADA KKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHI VQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP Click to Show/Hide
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| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Clinical Trial Drug(s) | [+] 1 Clinical Trial Drugs | + | ||||
| 1 | ATL1103 | Drug Info | Phase 1 | Acromegaly | [2] | |
| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 4 KEGG Pathways | + | ||||
| 1 | Cytokine-cytokine receptor interaction | |||||
| 2 | Neuroactive ligand-receptor interaction | |||||
| 3 | PI3K-Akt signaling pathway | |||||
| 4 | Jak-STAT signaling pathway | |||||
| PID Pathway | [+] 1 PID Pathways | + | ||||
| 1 | Notch-mediated HES/HEY network | |||||
| Reactome | [+] 2 Reactome Pathways | + | ||||
| 1 | Prolactin receptor signaling | |||||
| 2 | Growth hormone receptor signaling | |||||
| WikiPathways | [+] 3 WikiPathways | + | ||||
| 1 | Endochondral Ossification | |||||
| 2 | Prolactin receptor signaling | |||||
| 3 | Growth hormone receptor signaling | |||||
| References | Top | |||||
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| REF 1 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). | |||||
| REF 2 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). | |||||
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