Target Information
| Target General Information | Top | |||||
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| Target ID |
T11747
(Former ID: TTDR01422)
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| Target Name |
MEKK3 messenger RNA (MAP3K3 mRNA)
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| Synonyms |
Mitogen-activated protein kinase kinase kinase 3 (mRNA); MEKK3 (mRNA); MEKK 3 (mRNA); MEK kinase 3 (mRNA); MAPKKK3 (mRNA)
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| Gene Name |
MAP3K3
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| Target Type |
Literature-reported target
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[1] | ||||
| Function |
Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. Component of a protein kinase signal transduction cascade.
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| BioChemical Class |
mRNA target
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| UniProt ID | ||||||
| EC Number |
EC 2.7.11.25
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| Sequence |
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL RRIFVEARQRPSAEELLTHHFAQLMY Click to Show/Hide
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| Cell-based Target Expression Variations | Top | |||||
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| Cell-based Target Expression Variations | ||||||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 4 KEGG Pathways | + | ||||
| 1 | MAPK signaling pathway | |||||
| 2 | Neurotrophin signaling pathway | |||||
| 3 | GnRH signaling pathway | |||||
| 4 | HTLV-I infection | |||||
| NetPath Pathway | [+] 1 NetPath Pathways | + | ||||
| 1 | TSH Signaling Pathway | |||||
| Panther Pathway | [+] 3 Panther Pathways | + | ||||
| 1 | B cell activation | |||||
| 2 | EGF receptor signaling pathway | |||||
| 3 | FGF signaling pathway | |||||
| PID Pathway | [+] 4 PID Pathways | + | ||||
| 1 | p38 MAPK signaling pathway | |||||
| 2 | Regulation of p38-alpha and p38-beta | |||||
| 3 | IL1-mediated signaling events | |||||
| 4 | TNF receptor signaling pathway | |||||
| Reactome | [+] 1 Reactome Pathways | + | ||||
| 1 | Interleukin-1 signaling | |||||
| WikiPathways | [+] 8 WikiPathways | + | ||||
| 1 | Insulin Signaling | |||||
| 2 | EGF/EGFR Signaling Pathway | |||||
| 3 | MAPK Cascade | |||||
| 4 | Structural Pathway of Interleukin 1 (IL-1) | |||||
| 5 | EBV LMP1 signaling | |||||
| 6 | TNF alpha Signaling Pathway | |||||
| 7 | IL-1 signaling pathway | |||||
| 8 | Interleukin-1 signaling | |||||
| References | Top | |||||
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| REF 1 | US patent application no. 6,498,035, Antisense modulation of MEKK3 expression. | |||||
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