Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
References
Drug Binding Sites of Target  Top
Ligand Name: Acetylcysteine Ligand Info
Structure Description MUTANT HUMAN LYSOZYME C77A PDB:207L
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [2]
PDB Sequence
KVFERCELAR
10
TLKRLGMDGY
20
RGISLANWMC
30
LAKWESGYNT
40
RATNYNAGDR
50

STDYGIFQIN
60
SRYWCNDGKT
70
PGAVNAAHLS
80
CSALLQDNIA
90
DAVACAKRVV
100

RDPQGIRAWV
110
AWRNRCQNRD
120
VRQYVQGCGV
130
Residue
Distance (Å)
TYR63
3.318
TRP64
2.956
VAL74
4.425
HIS78
3.155
Residue
Distance (Å)
LEU79
3.262
CYS95
2.031
ARG98
4.116
VAL99
4.867
Ligand Name: Glutathione Ligand Info
Structure Description CRYSTAL STRUCTURE OF A GLUTATHIONYLATED HUMAN LYSOZYME: A FOLDING INTERMEDIATE MIMIC IN THE FORMATION OF A DISULFIDE BOND PDB:1HNL
Method X-ray diffraction Resolution 1.80 Å Mutation No [3]
PDB Sequence
KVFERCELAR
10
TLKRLGMDGY
20
RGISLANWMC
30
LAKWESGYNT
40
RATNYNAGDR
50

STDYGIFQIN
60
SRYWCNDGKT
70
PGAVNAAHLS
80
CSALLQDNIA
90
DAVACAKRVV
100

RDPQGIRAWV
110
AWRNRCQNRD
120
VRQYVQGCGV
130
Residue
Distance (Å)
TYR63
2.766
TRP64
2.745
CYS65
4.930
ALA76
4.279
ALA77
2.468
Residue
Distance (Å)
HIS78
4.030
LEU79
3.136
CYS95
2.055
ARG98
2.888
VAL99
4.713
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
 Download Picture         KEGG Link      
KEGG Pathway Pathway ID Affiliated Target Pathway Map
Salivary secretion hsa04970 Affiliated Target
  Class: Organismal Systems => Digestive system Pathway Hierarchy

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