Target Information

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Target General Information
Drugs and Modes of Action
Drug Binding Sites of Target
Different Human System Profiles of Target
References
Drug Binding Sites of Target  Top
Ligand Name: Beta-D-Mannose Ligand Info
Structure Description CirpA1 in complex with pseudo-monomeric Properdin lacking TSR2-3 PDB:7B26
Method X-ray diffraction Resolution 3.40 Å Mutation Yes [6]
PDB Sequence
WGPWGPVSPC
269
PVTCGLGQTM
279
EQRTCNCAGD
299
ATRTHICNTA
309
VPCPVDGEWD
319

SWGEWSPCIR
329
RNMKSISCQE
339
IPGQQSRGRT
349
CRGRKFDGHR
359
CAGQQQDIRH
369

CYSIQHCPLK
379
GSWSEWSTWG
389
LCMPPCGPNP
399
TRARQRLCTP
409
LLPKYPPTVS
419

GEKNVTFWGR
434
PLPRCEELQG
444
QKLVVEEKRP
454
CLHVPACKDP
464
E
Residue
Distance (Å)
GLY261
4.215
PRO262
4.117
TRP263
1.491
Residue
Distance (Å)
ARG282
4.413
ARG302
3.577
Ligand Name: Alpha-D-Mannose Ligand Info
Structure Description Crystal Structure of Properdin (TSR domains N1 & 456) PDB:6S08
Method X-ray diffraction Resolution 2.03 Å Mutation No [7]
PDB Sequence
> Chain A
SVAGGWGPWG
264
PVSPCPVTCG
274
LGQTMEQRTC
284
NHPVPQHGGP
294
FCAGDATRTH
304

ICNTAVPCPV
314
DGEWDSWGEW
324
SPCIRRNMKS
334
ISCQEIPGQQ
344
SRGRTCRGRK
354

FDGHRCAGQQ
364
QDIRHCYSIQ
374
HCPLKGSWSE
384
WSTWGLCMPP
394
CGPNPTRARQ
404

RLCTPLLPKY
414
PPTVGEKNVT
430
FWGRPLPRCE
440
ELQGQKLVVE
450
EKRPCLHVPA
460

CKDPEE
> Chain B
DPVLCFTQYE
37
ESSGKCKGLL
47
GGGVSVEDCC
57
LNTAFAYQKR
67
SGGLCQPCRS
77

PRWSLWSTWA
87
PCSVTCSEGS
97
QLRYRRCVGW
107
NGQCSGKVAP
117
GTLEWQLQAC
127

EDQQC
Residue [Chain]
Distance (Å)
GLY258[A]
4.305
GLY259[A]
3.733
TRP260[A]
1.509
GLY261[A]
4.121
PRO262[A]
3.617
TRP263[A]
1.511
ARG282[A]
3.016
CYS296[A]
3.520
ALA297[A]
2.790
GLY298[A]
4.765
ARG302[A]
3.151
ASP319[A]
4.314
SER320[A]
3.058
TRP321[A]
1.510
GLY322[A]
3.904
GLU323[A]
2.483
TRP324[A]
1.514
ARG346[A]
2.989
ARG368[A]
3.193
GLY380[A]
4.459
SER381[A]
3.826
Residue [Chain]
Distance (Å)
TRP382[A]
1.512
GLU384[A]
2.356
TRP385[A]
1.503
SER386[A]
3.688
THR387[A]
2.851
TRP388[A]
1.513
ARG401[A]
3.179
ARG403[A]
2.912
ARG405[A]
4.264
PHE431[A]
4.498
TRP432[A]
3.150
GLY433[A]
4.709
CYS439[A]
4.071
GLU440[A]
3.126
LEU442[A]
3.869
SER81[B]
3.923
LEU82[B]
3.080
TRP83[B]
1.518
ARG100[B]
2.726
ARG102[B]
4.881
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Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
Degree 6 Degree centrality 6.45E-04 Betweenness centrality 7.85E-05
Closeness centrality 1.66E-01 Radiality 1.26E+01 Clustering coefficient 2.00E-01
Neighborhood connectivity 9.67E+00 Topological coefficient 1.98E-01 Eccentricity 13
Download Click to Download the Full PPI Network of This Target

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