Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T05880
|
|||||
| Target Name |
Gamma-secretase subunit APH-1A/1B (APH-1)
|
|||||
| Synonyms |
Anterior pharynx-defective 1
Click to Show/Hide
|
|||||
| Gene Name |
APH1A-APH1B
|
|||||
| Target Type |
Patented-recorded target
|
[1] | ||||
| Disease | [+] 2 Target-related Diseases | + | ||||
| 1 | Alzheimer disease [ICD-11: 8A20] | |||||
| 2 | Herpes simplex infection [ICD-11: 1F00] | |||||
| Function |
The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Click to Show/Hide
|
|||||
| UniProt ID | ||||||
| Sequence |
MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII
DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVS GLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDG CEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKL CLLCQDKNFLLYNQRSRMGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWL VSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLAS LSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFL TAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVS MGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED Click to Show/Hide
|
|||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Patented Agent(s) | [+] 4 Patented Agents | + | ||||
| 1 | PMID28350212-Compound-18 | Drug Info | Patented | Alzheimer disease | [1] | |
| 2 | PMID28350212-Compound-19 | Drug Info | Patented | Alzheimer disease | [1] | |
| 3 | PMID28350212-Compound-20 | Drug Info | Patented | Alzheimer disease | [1] | |
| 4 | PMID28350212-Compound-7 | Drug Info | Patented | Herpes simplex virus infection | [1] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Inhibitor | [+] 18 Inhibitor drugs | + | ||||
| 1 | PMID28350212-Compound-1 | Drug Info | [1] | |||
| 2 | PMID28350212-Compound-12 | Drug Info | [1] | |||
| 3 | PMID28350212-Compound-13 | Drug Info | [1] | |||
| 4 | PMID28350212-Compound-15 | Drug Info | [1] | |||
| 5 | PMID28350212-Compound-16 | Drug Info | [1] | |||
| 6 | PMID28350212-Compound-18 | Drug Info | [1] | |||
| 7 | PMID28350212-Compound-19 | Drug Info | [1] | |||
| 8 | PMID28350212-Compound-20 | Drug Info | [1] | |||
| 9 | PMID28350212-Compound-21 | Drug Info | [1] | |||
| 10 | PMID28350212-Compound-22 | Drug Info | [1] | |||
| 11 | PMID28350212-Compound-23 | Drug Info | [1] | |||
| 12 | PMID28350212-Compound-24 | Drug Info | [1] | |||
| 13 | PMID28350212-Compound-25 | Drug Info | [1] | |||
| 14 | PMID28350212-Compound-30 | Drug Info | [1] | |||
| 15 | PMID28350212-Compound-35 | Drug Info | [1] | |||
| 16 | PMID28350212-Compound-36 | Drug Info | [1] | |||
| 17 | PMID28350212-Compound-7 | Drug Info | [1] | |||
| 18 | Sulfonamide derivative 15 | Drug Info | [2] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. | |||||
| REF 2 | Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.