Target Information
Target General Information | Top | |||||
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Target ID |
T05249
(Former ID: TTDI01504)
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Target Name |
Zinc alpha-2 glycoprotein (AZGP1)
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Synonyms |
Zn-alpha-2-glycoprotein; Zn-alpha-2-GP; Zinc-alpha-2-glycoprotein; ZNGP1; ZAG
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Gene Name |
AZGP1
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Target Type |
Literature-reported target
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[1] | ||||
Function |
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.
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UniProt ID | ||||||
Sequence |
MVRMVPVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFR
YNSKDRKSQPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGR FGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKA YLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWT RAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS Click to Show/Hide
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3D Structure | Click to Show 3D Structure of This Target | PDB |
Cell-based Target Expression Variations | Top | |||||
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Cell-based Target Expression Variations |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: 11-(Dansylamino)undecanoic acid | Ligand Info | |||||
Structure Description | Zinc-alpha2-Glycoprotein with a Fluorescent Dansyl C 11 Fatty Acid | PDB:6R2U | ||||
Method | X-ray diffraction | Resolution | 2.49 Å | Mutation | No | [2] |
PDB Sequence |
DGRYSLTYIY
14 TGLSKHVEDV24 PAFQALGSLN34 DLQFFRYNSK44 DRKSQPMGLW54 RQVEGMEDWK 64 QDSQLQKARE74 DIFMETLKDI84 VEYYNDSNGS94 HVLQGRFGCE104 IENNRSSGAF 114 WKYYYDGKDY124 IEFNKEIPAW134 VPFDPAAQIT144 KQKWEAEPVY154 VQRAKAYLEE 164 ECPATLRKYL174 KYSKNILDRQ184 DPPSVVVTSH194 QAPGEKKKLK204 CLAYDFYPGK 214 IDVHWTRAGE224 VQEPELRGDV234 LHNGNGTYQS244 WVVVAVPPQD254 TAPYSCHVQH 264 SSLAQPLVVP274 WE
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Click to View More Binding Site Information of This Target with Different Ligands |
Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution
of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects
(Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors
of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information
(Front Pharmacol, 9, 1245, 2018;
Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
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There is no similarity protein (E value < 0.005) for this target
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Note:
If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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Degree | 1 | Degree centrality | 1.07E-04 | Betweenness centrality | 0.00E+00 |
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Closeness centrality | 1.57E-01 | Radiality | 1.22E+01 | Clustering coefficient | 0.00E+00 |
Neighborhood connectivity | 2.00E+00 | Topological coefficient | 1.00E+00 | Eccentricity | 14 |
Download | Click to Download the Full PPI Network of This Target | ||||
References | Top | |||||
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REF 1 | Modulation by interferon-gamma of zinc-alpha 2-glycoprotein gene expression in human epithelial cell lines. Anticancer Res. 1997 Sep-Oct;17(5A):3387-91. | |||||
REF 2 | Crystal structure of zinc-Alpha2-glycoprotein in complex with a fatty acid reveals multiple different modes of protein-lipid binding. Biochem J. 2019 Oct 15;476(19):2815-2834. |
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