Target Information

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Target General Information
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
References
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
Protein Name Pfam ID Percentage of Identity (%) E value
Mixed lineage kinase 1 (MAP3K9)
PF00069 ; 
PF14604
32.246 (89/276) 1.39E-32
NIMA-related kinase 7 (NEK7)
PF00069
26.962 (79/293) 1.45E-24
Omphalocele kinase 1 (NUAK1)
PF00069
29.388 (72/245) 2.42E-23
Serine/threonine-protein kinase Nek5 (NEK5)
PF00069
23.828 (61/256) 1.18E-22
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
PF16579 ; 
PF00069
29.297 (75/256) 1.42E-22
NUAK family SNF1-like kinase 2 (NUAK2)
PF00069
29.151 (79/271) 4.53E-22
Ribosomal protein S6 kinase alpha-6 (RSK6)
PF00069 ; 
PF00433
28.685 (72/251) 6.58E-22
Ribosomal protein S6 kinase alpha-2 (RSK2)
PF00069 ; 
PF00433
27.888 (70/251) 1.38E-21
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
PF16579 ; 
PF00069
29.020 (74/255) 2.42E-21
Ribosomal protein S6 kinase alpha-3 (RSK3)
PF00069 ; 
PF00433
27.600 (69/250) 5.92E-21
Aurora kinase A (AURKA)
PF00069
27.925 (74/265) 7.35E-21
Ribosomal protein S6 kinase alpha-1 (RSK1)
PF00069 ; 
PF00433
27.888 (70/251) 1.49E-20
Serine/threonine-protein kinase ULK1 (ULK1)
PF12063 ; 
PF00069
29.224 (64/219) 5.50E-20
MAP/microtubule affinity-regulating kinase 4 (MARK4)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.362 (69/235) 7.17E-20
Salt-inducible kinase 2 (SIK2)
PF00069
30.493 (68/223) 7.58E-20
Leucine-rich repeat kinase 2 (LRRK2)
PF16095 ; 
PF12799 ; 
PF13855 ; 
PF00069 ; 
PF08477
More >>
 30.888 (80/259) 1.01E-19
Microtubule affinity regulating kinase 3 (MARK3)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.412 (70/238) 1.09E-19
Myosin light chain kinase 2 (MYLK2)
PF00069
30.804 (69/224) 1.16E-19
Aurora kinase C (AURKC)
PF00069
26.848 (69/257) 1.19E-19
Polo-like kinase 4 (PLK4)
PF00069 ; 
PF18190 ; 
PF18409
More >>
 27.692 (72/260) 1.85E-19
Polo-like kinase 2 (PLK2)
PF00069 ; 
PF00659
25.794 (65/252) 2.11E-19
Serine/threonine-protein kinase MARK1 (MARK1)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 26.502 (75/283) 2.81E-19
NIMA-related kinase 6 (NEK6)
PF00069
25.524 (73/286) 5.51E-19
Salt-inducible kinase 1 (SIK1)
PF00069
29.596 (66/223) 1.05E-18
Putative serine/threonine-protein kinase SIK1B (SIK1B)
PF00069
29.596 (66/223) 1.15E-18
Serine/threonine-protein kinase MARK2 (MARK2)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 28.571 (68/238) 1.43E-18
Serine/threonine-protein kinase Nek3 (NEK3)
PF00069
24.603 (62/252) 1.89E-18
SIK family kinase 3 (SIK3)
PF00069
30.088 (68/226) 1.97E-18
Serine/threonine-protein kinase STK11 (STK11)
PF00069
30.970 (83/268) 2.44E-18
Cyclin-dependent kinase 15 (CDK15)
PF00069
31.441 (72/229) 3.10E-18
Death-associated protein kinase 2 (DAPK2)
PF00069
27.419 (68/248) 3.57E-18
Protein kinase C beta (PRKCB)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 28.636 (63/220) 3.87E-18
Serine/threonine-protein kinase ULK2 (ULK2)
PF12063 ; 
PF00069
29.032 (63/217) 4.10E-18
Myosin light chain kinase family member 4 (MYLK4)
PF00069
30.660 (65/212) 4.40E-18
Testis-specific serine/threonine-protein kinase 4 (TSSK4)
PF00069
25.000 (68/272) 4.89E-18
Myosin light chain kinase 3 (MYLK3)
PF00069
31.925 (68/213) 5.70E-18
Protein kinase C alpha (PRKCA)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 25.620 (62/242) 6.42E-18
Cyclin-dependent kinase 2 (CDK2)
PF00069
26.800 (67/250) 8.45E-18
Cyclin-dependent kinase 3 (CDK3)
PF00069
27.706 (64/231) 8.69E-18
Fused homolog (STK36)
PF13646 ; 
PF00069
27.619 (58/210) 1.34E-17
Proto-oncogene serine/threonine-protein kinase mos (MOS)
PF00069
28.094 (84/299) 1.36E-17
Aurora kinase B (AURKB)
PF00069
26.335 (74/281) 1.45E-17
Serine/threonine-protein kinase Nek4 (NEK4)
PF00069
26.744 (69/258) 2.20E-17
Hormonally up-regulated neu tumor-associated kinase (HUNK)
PF00069
29.600 (74/250) 3.39E-17
Death-associated protein kinase 3 (DAPK3)
PF00069
27.826 (64/230) 3.53E-17
Serine/threonine-protein kinase PLK3 (PLK3)
PF00069 ; 
PF00659
27.823 (69/248) 4.60E-17
Serine/threonine-protein kinase Nek11 (NEK11)
PF00069
25.397 (64/252) 7.89E-17
Unc-51 like kinase 3 (ULK3)
PF04212 ; 
PF00069
28.627 (73/255) 9.78E-17
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 25.000 (84/336) 1.07E-16
SPS1/STE20-related protein kinase YSK4 (YSK4)
PF00069
28.405 (73/257) 1.07E-16
Polo-like kinase 1 (PLK1)
PF00069 ; 
PF00659
27.488 (58/211) 2.18E-16
Cyclin-dependent kinase 16 (CDK16)
PF12330 ; 
PF00069
29.245 (62/212) 2.74E-16
Protein kinase C gamma (PRKCG)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 28.319 (64/226) 2.82E-16
MEK kinase kinase 1 (MAP4K1)
PF00780 ; 
PF00069
26.217 (70/267) 2.85E-16
Serine/threonine-protein kinase 33 (STK33)
PF00069
29.310 (68/232) 3.05E-16
Death-associated protein kinase 1 (DAPK1)
PF00023 ; 
PF12796 ; 
PF13637 ; 
PF00531 ; 
PF00069
More >>
 28.947 (66/228) 3.09E-16
NIMA-related kinase 1 (NEK1)
PF00069
20.800 (52/250) 4.82E-16
Cyclin-dependent kinase 1 (CDK1)
PF00069
27.350 (64/234) 5.73E-16
MAPK/ERK kinase kinase 3 (MAP3K3)
PF00564 ; 
PF00069
29.412 (65/221) 6.31E-16
Serine/threonine-protein kinase 32A (STK32A)
PF00069
23.922 (61/255) 6.37E-16
BR serine/threonine kinase 1 (BRSK1)
PF00069
26.275 (67/255) 6.97E-16
BR serine/threonine kinase 2 (BRSK2)
PF00069
28.311 (62/219) 8.09E-16
MAPK/ERK kinase kinase 4 (MAP3K4)
PF19431 ; 
PF00069
25.896 (65/251) 1.02E-15
Apoptosis signal-regulating kinase 2 (MAP3K6)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 28.000 (70/250) 1.46E-15
Myosin light kinase (MYLK)
PF16620 ; 
PF00041 ; 
PF07679 ; 
PF00069
More >>
 26.126 (58/222) 3.23E-15
Cyclin-dependent kinase 14 (CDK14)
PF00069
29.245 (62/212) 3.99E-15
Cyclin-dependent kinase-like 2 (CDKL2)
PF00069
28.829 (64/222) 4.04E-15
Cyclin-dependent kinase 5 (CDK5)
PF00069
26.761 (57/213) 5.79E-15
Extracellular signal-regulated kinase 5 (ERK5)
PF00069
26.641 (69/259) 6.62E-15
Serine/threonine-protein kinase 26 (STK26)
PF00069
26.906 (60/223) 7.59E-15
Cyclin-dependent kinase 17 (CDK17)
PF12330 ; 
PF00069
26.887 (57/212) 7.64E-15
Protein kinase C delta (PRKCD)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 28.700 (64/223) 7.72E-15
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
PF00069
27.556 (62/225) 8.25E-15
CaM-kinase IV kinase (CAMKK1)
PF00069
32.143 (54/168) 8.35E-15
Serine/threonine-protein kinase ICK (CILK1)
PF00069
27.586 (56/203) 8.66E-15
Apoptosis signal-regulating kinase 1 (MAP3K5)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 26.337 (64/243) 1.10E-14
Serine/threonine-protein kinase NIM1 (NIM1K)
PF00069
27.273 (66/242) 1.20E-14
Putative 3-phosphoinositide-dependent protein kinase 2 (PDPK2P)
PF00069
21.622 (48/222) 1.25E-14
NIMA-related kinase 2 (NEK2)
PF00069
29.730 (55/185) 1.25E-14
Protein kinase C theta (PRKCQ)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 24.183 (74/306) 1.79E-14
Phosphoinositide dependent protein kinase-1 (PDPK1)
PF14593 ; 
PF00069
21.622 (48/222) 2.22E-14
Maternal embryonic leucine zipper kinase (MELK)
PF02149 ; 
PF00069
26.482 (67/253) 2.36E-14
Cyclin-dependent kinase 18 (CDK18)
PF00069
27.358 (58/212) 2.70E-14
PKC-delta-interacting protein kinase (RIPK4)
PF12796 ; 
PF00069
28.364 (78/275) 2.77E-14
Stress-activated protein kinase 2a (p38 alpha)
PF00069
25.820 (63/244) 3.66E-14
MAP kinase p38 (MAPK12)
PF00069
28.249 (50/177) 3.98E-14
Serine/threonine-protein kinase pim-1 (PIM1)
PF00069
27.481 (72/262) 4.59E-14
Misshapen-like kinase 1 (MINK1)
PF00780 ; 
PF00069
25.000 (52/208) 5.33E-14
Anti-mullerian hormone II receptor (AMHR2)
PF00069
24.921 (79/317) 6.03E-14
SNF-related serine/threonine-protein kinase (SNRK)
PF00069
26.848 (69/257) 6.41E-14
Calmodulin-dependent kinase II (CAMKK2)
PF00069
30.120 (50/166) 6.51E-14
TRAF2 and NCK interacting kinase (TNIK)
PF00780 ; 
PF00069
26.471 (54/204) 7.08E-14
Serine/threonine-protein kinase MAK (MAK)
PF00069
27.638 (55/199) 7.08E-14
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)
PF00069 ; 
PF12721
29.924 (79/264) 8.46E-14
Extracellular signal-regulated kinase 2 (ERK2)
PF00069
28.934 (57/197) 8.59E-14
Testis-specific serine/threonine-protein kinase 1 (TSSK1B)
PF00069
30.000 (69/230) 9.09E-14
Ribosomal protein S6 kinase beta-2 (RPS6KB2)
PF00069 ; 
PF00433
25.681 (66/257) 9.17E-14
Serine/threonine-protein kinase Sgk1 (SGK1)
PF00069 ; 
PF00433
25.877 (59/228) 1.19E-13
Protein kinase C epsilon (PRKCE)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.027 (57/219) 1.25E-13
Serine/threonine-protein kinase 24 (STK24)
PF00069
26.540 (56/211) 1.35E-13
Testis-specific serine/threonine-protein kinase 6 (TSSK6)
PF00069
28.958 (75/259) 1.38E-13
Cyclin-dependent kinase 6 (CDK6)
PF00069
25.952 (75/289) 1.54E-13
MAPK/ERK kinase kinase 2 (MAP3K2)
PF00564 ; 
PF00069
25.862 (60/232) 2.29E-13
MST-1 protein kinase (STK4)
PF11629 ; 
PF00069
25.581 (55/215) 2.69E-13
Cyclin-dependent kinase 13 (CDK13)
PF12330 ; 
PF00069
27.805 (57/205) 3.33E-13
Ribosomal protein S6 kinase alpha-5 (RSK5)
PF00069 ; 
PF00433
29.808 (62/208) 3.50E-13
Serine/threonine-protein kinase 25 (STK25)
PF00069
28.125 (54/192) 4.65E-13
Serine/threonine-protein kinase Nek8 (NEK8)
PF00069 ; 
PF00415
25.200 (63/250) 4.85E-13
Stress-activated protein kinase 2b (p38 beta)
PF00069
27.917 (67/240) 4.97E-13
Serine/threonine-protein kinase 3 (STK3)
PF11629 ; 
PF00069
25.701 (55/214) 5.14E-13
Doublecortin-like kinase 3 (DCLK3)
PF00069
25.641 (50/195) 5.21E-13
Extracellular signal-regulated kinase 1 (ERK1)
PF00069
28.426 (56/197) 6.67E-13
ERK activator kinase 5 (MAP2K5)
PF00564 ; 
PF00069
26.210 (65/248) 7.63E-13
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
PF00069
27.193 (62/228) 8.62E-13
Homeodomain-interacting protein kinase 4 (HIPK4)
PF00069
28.992 (69/238) 8.88E-13
Testis-specific serine/threonine-protein kinase 3 (TSSK3)
PF00069
27.451 (70/255) 1.34E-12
Serine/threonine-protein kinase 32C (STK32C)
PF00069
23.346 (60/257) 1.43E-12
Cyclin-dependent kinase 12 (CDK12)
PF00069
27.317 (56/205) 1.49E-12
Activin receptor type IIB (ACVR2B)
PF01064 ; 
PF00069
23.024 (67/291) 1.61E-12
Protein kinase G1 (PRKG1)
PF00027 ; 
PF16808 ; 
PF00069
More >>
 25.984 (66/254) 1.62E-12
Serine/threonine-protein kinase pim-2 (PIM2)
PF00069
28.788 (76/264) 1.66E-12
Doublecortin-like kinase 1 (DCLK1)
PF03607 ; 
PF00069
24.775 (55/222) 1.69E-12
Serine/threonine-protein kinase NLK (NLK)
PF00069
25.871 (52/201) 1.78E-12
Serine/threonine-protein kinase D2 (PRKD2)
PF00130 ; 
PF00069
28.713 (58/202) 2.05E-12
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
PF08332 ; 
PF00069
27.511 (63/229) 2.21E-12
Tyrosine-protein kinase EIF2AK2 (p68)
PF00035 ; 
PF00069
20.195 (62/307) 2.43E-12
Serine/threonine-protein kinase WNK1 (WNK1)
PF12202 ; 
PF00069
26.038 (69/265) 2.58E-12
Doublecortin-like kinase 2 (DCLK2)
PF03607 ; 
PF00069
22.909 (63/275) 3.11E-12
WNK lysine-deficient protein kinase 3 (WNK3)
PF12202 ; 
PF00069
25.097 (65/259) 3.41E-12
Checkpoint kinase-1 (CHK1)
PF00069
28.505 (61/214) 3.43E-12
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
PF00780 ; 
PF00069
26.667 (56/210) 4.02E-12
Cyclin-dependent kinase-like 3 (CDKL3)
PF00069
27.919 (55/197) 4.11E-12
Oxidative stress responsive 1 (OXSR1)
PF12202 ; 
PF00069
24.514 (63/257) 4.21E-12
MAPK/ERK kinase kinase 1 (MAP3K1)
PF00069
23.675 (67/283) 4.63E-12
Protein kinase N2 (PKN2)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 28.279 (69/244) 5.54E-12
Ribosomal protein S6 kinase beta-1 (S6K1)
PF00069 ; 
PF00433
24.554 (55/224) 5.96E-12
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
PF00069
27.602 (61/221) 6.13E-12
Serine/threonine-protein kinase SBK1 (SBK1)
PF00069
27.149 (60/221) 6.33E-12
Protein kinase D (PRKD1)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 27.700 (59/213) 6.93E-12
Mitogen-activated protein kinase 15 (MAPK15)
PF00069
29.333 (66/225) 7.08E-12
MEK kinase kinase 4 (MAP4K4)
PF00780 ; 
PF00069
25.481 (53/208) 8.47E-12
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
PF08332 ; 
PF00069
26.638 (61/229) 9.67E-12
Yet another novel kinase 2 (STK32B)
PF00069
22.989 (60/261) 1.03E-11
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
PF12796 ; 
PF16095 ; 
PF00069 ; 
PF08477
More >>
 25.112 (56/223) 1.05E-11
Serine/threonine-protein kinase TAO2 (TAOK2)
PF00069
28.922 (59/204) 1.10E-11
Serine/threonine-protein kinase Sgk3 (SGK3)
PF00069 ; 
PF00433 ; 
PF00787
More >>
 25.229 (55/218) 1.20E-11
Serine/threonine-protein kinase 10 (STK10)
PF00069 ; 
PF12474
26.087 (66/253) 1.27E-11
Dual specificity protein kinase TTK (MPS1)
PF00069
23.022 (64/278) 1.43E-11
Serine/threonine-protein kinase PAK 6 (PAK6)
PF00786 ; 
PF00069
24.873 (49/197) 1.53E-11
Serine/threonine-protein kinase H1 (PSKH1)
PF00069
26.724 (62/232) 1.57E-11
Serine/threonine-protein kinase WNK4 (WNK4)
PF12202 ; 
PF00069
26.000 (65/250) 1.95E-11
Serine/threonine-protein kinase NIK (MAP3K14)
PF00069
32.124 (62/193) 2.29E-11
Protein kinase C eta type (PRKCH)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 24.434 (54/221) 2.29E-11
Cyclin-dependent kinase 10 (CDK10)
PF00069
27.885 (58/208) 2.34E-11
TGF-beta receptor type I (TGFBR1)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 25.106 (59/235) 2.38E-11
PAK-2 protein kinase (PAK2)
PF00786 ; 
PF00069
24.390 (50/205) 2.56E-11
Mitogen-activated protein kinase 13 (MAPK13)
PF00069
27.049 (66/244) 3.06E-11
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 25.837 (54/209) 3.09E-11
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
PF08332 ; 
PF00069
27.155 (63/232) 3.30E-11
Ste-20-related kinase (STK39)
PF12202 ; 
PF00069
23.077 (60/260) 3.35E-11
Testis-specific serine kinase 2 (TSSK2)
PF00069
26.293 (61/232) 3.50E-11
Activin receptor type IIA (ACVR2A)
PF01064 ; 
PF00069
22.759 (66/290) 3.73E-11
IL-1 receptor-associated kinase 1 (IRAK1)
PF00531 ; 
PF00069
23.397 (73/312) 4.07E-11
RAC-gamma serine/threonine-protein kinase (AKT3)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 23.109 (55/238) 4.31E-11
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 27.670 (57/206) 4.99E-11
Myosin-IIIa (MYO3A)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 22.794 (62/272) 6.75E-11
Serine/threonine-protein kinase Nek9 (NEK9)
PF00069 ; 
PF00415
21.825 (55/252) 7.36E-11
Serine/threonine-protein kinase Nek10 (NEK10)
PF00069
23.864 (63/264) 7.62E-11
MEK kinase kinase 2 (MAP4K2)
PF00780 ; 
PF00069
26.000 (52/200) 7.71E-11
Cyclin-dependent kinase 4 (CDK4)
PF00069
26.733 (54/202) 8.14E-11
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
PF08332 ; 
PF00069
27.193 (62/228) 8.33E-11
Serine/threonine-protein kinase greatwall (MASTL)
PF00069
26.875 (43/160) 9.27E-11
MEK kinase kinase 3 (MAP4K3)
PF00780 ; 
PF00069
26.020 (51/196) 9.74E-11
Activin receptor type IB (ACVR1B)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 25.592 (54/211) 1.02E-10
Serine/threonine-protein kinase PAK 5 (PAK5)
PF00786 ; 
PF00069
23.077 (45/195) 1.11E-10
Serine/threonine-protein kinase D3 (PRKD3)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 27.228 (55/202) 1.18E-10
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
PF00069
24.554 (55/224) 1.21E-10
Calcium/calmodulin-dependent protein kinase type 1B (PNCK)
PF00069
26.754 (61/228) 1.54E-10
Serine/threonine-protein kinase PAK 3 (PAK3)
PF00786 ; 
PF00069
23.077 (48/208) 1.56E-10
Serine/threonine-protein kinase 17B (STK17B)
PF00069
22.388 (45/201) 1.72E-10
Striated muscle preferentially expressed protein kinase (SPEG)
PF07679 ; 
PF00069 ; 
PF16650
More >>
 23.144 (53/229) 1.79E-10
Serine/threonine-protein kinase WNK2 (WNK2)
PF12202 ; 
PF00069
26.887 (57/212) 2.16E-10
STE20-related serine/threonine-protein kinase (SLK)
PF00069 ; 
PF12474
28.986 (60/207) 2.69E-10
Serine/threonine-protein kinase Sgk2 (SGK2)
PF00069 ; 
PF00433
23.182 (51/220) 2.72E-10
PIM-3 protein kinase (PIM3)
PF00069
27.660 (78/282) 2.85E-10
Cytoplasmic DRAK1 (STK17A)
PF00069
28.049 (46/164) 3.44E-10
G protein-coupled receptor kinase 5 (GRK5)
PF00069 ; 
PF00615
24.658 (54/219) 3.58E-10
Cyclin-dependent kinase 20 (CDK20)
PF00069
26.180 (61/233) 3.59E-10
PAK-1 protein kinase (PAK1)
PF00786 ; 
PF00069
22.596 (47/208) 3.63E-10
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
PF00069
29.319 (56/191) 3.84E-10
RAC-beta serine/threonine-protein kinase (AKT2)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 22.088 (55/249) 4.58E-10
Serine/threonine-protein kinase tousled-like 2 (TLK2)
PF00069
23.616 (64/271) 4.58E-10
G protein-coupled receptor kinase 6 (GRK6)
PF00069 ; 
PF00615
25.000 (45/180) 5.60E-10
Cyclin-dependent kinase 7 (CDK7)
PF00069
28.141 (56/199) 6.03E-10
Mitogen-activated protein kinase 6 (MAPK6)
PF00069
26.540 (56/211) 6.40E-10
Cyclin-dependent kinase 9 (CDK9)
PF00069
26.961 (55/204) 6.61E-10
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 29.237 (69/236) 7.40E-10
Cyclin-dependent kinase-like 5 (CDKL5)
PF00069
25.701 (55/214) 7.73E-10
Triple functional domain protein (TRIO)
PF00650 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00018 ; 
PF00435
More >>
 29.104 (78/268) 8.05E-10
PAK-4 protein kinase (PAK4)
PF00786 ; 
PF00069
22.613 (45/199) 8.51E-10
Serine/threonine-protein kinase Chk2 (RAD53)
PF00498 ; 
PF00069
27.317 (56/205) 9.91E-10
Serine/threonine-protein kinase tousled-like 1 (TLK1)
PF00069
24.615 (64/260) 1.02E-09
Titin (TTN) 24.091 (53/220) 1.11E-09
ERK activator kinase 1 (MEK1)
PF00069
26.540 (56/211) 1.28E-09
TAO kinase 1 (TAOK1)
PF00069
27.861 (56/201) 1.61E-09
Putative serine/threonine-protein kinase PRKY (PRKY)
PF00069
24.424 (53/217) 1.67E-09
Rhodopsin kinase GRK7 (GRK7)
PF00069 ; 
PF00615
26.667 (64/240) 1.93E-09
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG)
PF00069
23.954 (63/263) 1.96E-09
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
PF00069 ; 
PF00433
34.737 (33/95) 1.99E-09
RAC-alpha serine/threonine-protein kinase (AKT1)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 23.200 (58/250) 2.09E-09
Bone morphogenetic protein receptor (BMPR2)
PF01064 ; 
PF00069
27.315 (59/216) 2.23E-09
Obscurin (OBSCN)
PF00041 ; 
PF07679 ; 
PF00612 ; 
PF00069 ; 
PF00621
More >>
 27.660 (52/188) 2.35E-09
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
PF00069
25.238 (53/210) 2.39E-09
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
PF00069
27.368 (52/190) 2.50E-09
BMP-2-inducible protein kinase (BMP2K)
PF15282 ; 
PF00069
24.354 (66/271) 2.53E-09
Protein kinase G2 (PRKG2)
PF00027 ; 
PF00069
23.333 (70/300) 3.21E-09
Nik-related protein kinase (NRK)
PF00780 ; 
PF00069
23.276 (54/232) 3.28E-09
Mitogen-activated protein kinase 4 (MAPK4)
PF00069
27.000 (54/200) 3.39E-09
Cyclin-dependent kinase-like 4 (CDKL4)
PF00069
24.887 (55/221) 3.58E-09
Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
PF00069
29.730 (33/111) 3.76E-09
Tau-tubulin kinase (TTBK1)
PF00069
26.697 (59/221) 5.41E-09
Cyclin-G-associated kinase (GAK)
PF00069 ; 
PF10409
23.466 (65/277) 5.84E-09
Serine/threonine-protein kinase cot (COT)
PF00069
26.816 (48/179) 7.34E-09
Phosphorylase kinase testis gamma 2 (PHKG2)
PF00069
24.257 (49/202) 7.57E-09
Protein kinase N1 (PKN1)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.092 (68/251) 8.89E-09
Protein kinase C iota (PRKCI)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 23.457 (57/243) 9.07E-09
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
PF00069
22.400 (56/250) 9.17E-09
ERK activator kinase 2 (MEK2)
PF00069
27.111 (61/225) 1.14E-08
Protein kinase C zeta (PRKCZ)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 23.944 (51/213) 1.24E-08
PRKR-like endoplasmic reticulum kinase (PERK)
PF00069
26.000 (52/200) 1.28E-08
Serine/threonine-protein kinase ULK4 (ULK4)
PF00069
21.610 (51/236) 1.61E-08
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
PF00069
30.435 (35/115) 1.62E-08
TBC domain-containing protein kinase-like protein (TBCK)
PF00069 ; 
PF00566 ; 
PF00581
More >>
 24.561 (56/228) 1.63E-08
Tau-tubulin kinase 2 (TTBK2)
PF00069
25.792 (57/221) 1.71E-08
Cyclin-dependent kinase 11A (CDK11A)
PF00069
26.887 (57/212) 1.94E-08
Serine/threonine-protein kinase H2 (PSKH2)
PF00069
24.510 (50/204) 2.33E-08
Cyclin-dependent kinase 11B (CDK11B)
PF00069
25.000 (61/244) 2.66E-08
STE20-related kinase adapter protein beta (STRADB)
PF00069
23.047 (59/256) 2.83E-08
ERK activator kinase 7 (MAP2K7)
PF00069
24.615 (64/260) 5.20E-08
Protein kinase N3 (PKN3)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.200 (68/250) 6.27E-08
Myosin-IIIb (MYO3B)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 24.453 (67/274) 6.61E-08
Glycogen synthase kinase-3 beta (GSK-3B)
PF00069
26.180 (61/233) 7.88E-08
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
PF00069
26.563 (51/192) 8.61E-08
Glycogen synthase kinase-3 alpha (GSK-3A)
PF00069
27.803 (62/223) 1.06E-07
Endoplasmic reticulum to nucleus signaling 1 (ERN1)
PF00069 ; 
PF06479
26.108 (53/203) 1.18E-07
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
PF00069
24.312 (53/218) 1.35E-07
Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3)
PF00069
25.541 (59/231) 1.56E-07
TAO kinase 3 (TAOK3)
PF00069
27.895 (53/190) 1.57E-07
Casein kinase I epsilon (CSNK1E)
PF00069
22.744 (63/277) 1.83E-07
Casein kinase I delta (CSNK1D)
PF00069
22.744 (63/277) 2.09E-07
Cyclin-dependent kinase-like 1 (CDKL1)
PF00069
24.615 (48/195) 2.34E-07
NF-kappa-B-activating kinase (TBK1)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 30.043 (70/233) 2.36E-07
Ribosomal protein S6 kinase-related protein (RSKR)
PF00069
28.846 (30/104) 2.48E-07
Kalirin (KALRN)
PF13716 ; 
PF00041 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00435
More >>
 25.283 (67/265) 2.77E-07
CDC42 binding protein kinase alpha (DMPK-like alpha)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069 ; 
PF00433
More >>
 25.532 (60/235) 3.46E-07
G protein-coupled receptor kinase 4 (GRK4)
PF00069 ; 
PF00615
25.153 (41/163) 3.60E-07
Stress-activated protein kinase JNK2 (JNK2)
PF00069
24.413 (52/213) 3.60E-07
Rhodopsin kinase GRK1 (GRK1)
PF00069 ; 
PF00615
28.125 (36/128) 5.03E-07
Cyclin-dependent kinase 8 (CDK8)
PF00069
24.155 (50/207) 7.11E-07
CDC-like kinase 4 (CLK4)
PF00069
25.676 (57/222) 7.95E-07
Stress-activated protein kinase JNK1 (JNK1)
PF00069
27.215 (43/158) 8.05E-07
IL-1 receptor-associated kinase 3 (IRAK3)
PF00531 ; 
PF00069
26.214 (54/206) 9.17E-07
MAPK/MAK/MRK overlapping kinase (MOK)
PF00069
26.866 (54/201) 9.20E-07
Homeodomain-interacting protein kinase 1 (HIPK1)
PF00069
26.577 (59/222) 9.77E-07
Stress-activated protein kinase JNK3 (JNK3)
PF00069
27.097 (42/155) 9.83E-07
Adaptor-associated kinase 1 (AAK1)
PF00069
22.383 (62/277) 1.09E-06
Homeodomain-interacting protein kinase 3 (HIPK3)
PF00069
26.244 (58/221) 1.20E-06
CDC-like kinase 1 (CLK1)
PF00069
26.126 (58/222) 1.23E-06
Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)
PF00069 ; 
PF06479
30.288 (63/208) 1.24E-06
Cyclin-dependent kinase 19 (CDK19)
PF00069
24.155 (50/207) 1.73E-06
Serine/threonine-protein kinase MRCK beta (CDC42BPB)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069
More >>
 24.554 (55/224) 1.98E-06
Serine/threonine-protein kinase MRCK gamma (CDC42BPG)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF00069
More >>
 25.778 (58/225) 2.16E-06
Homeodomain interacting protein kinase 2 (HIPK2)
PF00069
26.244 (58/221) 2.86E-06
Membrane-associated kinase (PKMYT1)
PF00069
25.000 (76/304) 3.03E-06
Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2)
PF00069
24.424 (53/217) 3.05E-06
Serine/threonine-protein kinase PRP4 homolog (PRPF4B)
PF00069
24.887 (55/221) 3.11E-06
TGF-beta-stimulated factor 1 (STK16)
PF00069
19.780 (54/273) 4.99E-06
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
PF00069
27.044 (43/159) 5.27E-06
CDC-like kinase 3 (CLK3)
PF00069
25.217 (58/230) 6.19E-06
Dual-specificity tyrosine-phosphorylation regulated kinase 4 (DYRK4)
PF00069
25.000 (57/228) 6.66E-06
Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 24.841 (39/157) 7.27E-06
Casein kinase I alpha (CSNK1A1)
PF00069
22.222 (64/288) 7.32E-06
Casein kinase I isoform alpha-like (CSNK1A1L)
PF00069
22.759 (66/290) 7.45E-06
Casein kinase II alpha (CSNK2A1)
PF00069
21.333 (48/225) 9.64E-06
Peripheral plasma membrane protein CASK (CASK)
PF00625 ; 
PF02828 ; 
PF00595 ; 
PF00069 ; 
PF00018
More >>
 23.158 (44/190) 1.38E-05
PDZ binding kinase (PBK)
PF00069
23.967 (58/242) 1.44E-05
PAS domain-containing serine/threonine-protein kinase (PASK)
PF13426 ; 
PF00069
25.000 (52/208) 1.58E-05
Myotonin-protein kinase (DMPK)
PF08826 ; 
PF00069
22.467 (51/227) 2.10E-05
Serine/threonine-protein kinase SBK2 (SBK2)
PF00069
28.638 (61/213) 3.42E-05
Casein kinase II alpha prime (CSNK2A2)
PF00069
20.889 (47/225) 3.47E-05
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 24.026 (37/154) 3.84E-05
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
PF00069
25.210 (60/238) 3.85E-05
Casein kinase II subunit alpha 3 (CSNK2A3)
PF00069
20.889 (47/225) 4.14E-05
Citron Rho-interacting kinase (CIT)
PF00780 ; 
PF00169 ; 
PF00069
More >>
 29.630 (32/108) 4.97E-05
Serine/threonine-protein kinase 40 (STK40)
PF00069
25.625 (41/160) 5.15E-05
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A)
PF00069
24.464 (57/233) 5.83E-05
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
PF00069
27.439 (45/164) 5.97E-05
CaM kinase-like vesicle-associated protein (CAMKV)
PF00069
24.020 (49/204) 6.72E-05
Tribbles homolog 2 (TRIB2)
PF00069
24.870 (48/193) 7.95E-05
Beta-adrenergic receptor kinase 2 (ADRBK2)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 26.220 (43/164) 8.20E-05
Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 24.800 (31/125) 8.21E-05
Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4)
PF12745 ; 
PF00069 ; 
PF05773 ; 
PF13393
More >>
 24.528 (26/106) 8.56E-05
Serine/threonine-protein kinase LATS1 (LATS1)
PF00069 ; 
PF00627
22.259 (67/301) 1.15E-04
MAP kinase signal-integrating kinase 2 (MKNK2)
PF00069
24.171 (51/211) 1.20E-04
SRSF protein kinase 1 (SRPK1)
PF00069
29.371 (42/143) 1.24E-04
Beta-adrenergic receptor kinase 1 (ADRBK1)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 23.394 (51/218) 1.59E-04
Casein kinase I gamma-1 (CSNK1G1)
PF12605 ; 
PF00069
25.641 (70/273) 2.04E-04
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8L2)
PF08416 ; 
PF18016 ; 
PF00018
More >>
 38.095 (32/84) 2.20E-04
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 26.271 (31/118) 2.88E-04
Ribosomal protein S6 kinase-like 1 (RPS6KL1)
PF04212 ; 
PF00069
27.027 (30/111) 3.24E-04
Large tumor suppressor homolog 2 (LATS2)
PF00069 ; 
PF00433
19.476 (52/267) 3.48E-04
NDR1 protein kinase (STK38)
PF00069 ; 
PF00433
19.920 (50/251) 5.31E-04
MAPK-activated protein kinase 2 (MAPKAPK2)
PF00069
21.717 (43/198) 7.34E-04
Casein kinase I gamma-2 (CSNK1G2)
PF12605 ; 
PF00069
25.725 (71/276) 7.62E-04
NDR2 protein kinase (STK38L)
PF00069 ; 
PF00433
19.368 (49/253) 8.49E-04
SRSF protein kinase 3 (SRPK3)
PF00069
27.465 (39/142) 1.00E-03
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)
PF00531 ; 
PF00069
23.902 (49/205) 1.00E-03
MAPK-activated protein kinase 5 (MAPKAPK5)
PF00069
23.780 (39/164) 1.00E-03
CDC-like kinase 2 (CLK2)
PF00069
22.822 (55/241) 2.00E-03
MAPK-activated protein kinase 3 (MAPKAPK3)
PF00069
21.970 (29/132) 2.00E-03
SRSF protein kinase 2 (SRPK2)
PF00069
27.742 (43/155) 2.00E-03
Ribosomal protein S6 kinase delta-1 (RPS6KC1)
PF04212 ; 
PF00069 ; 
PF00787
More >>
 25.166 (38/151) 3.00E-03
Inactive serine/threonine-protein kinase VRK3 (VRK3)
PF00069 ; 
PF13240
22.727 (45/198) 4.00E-03
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