Target Information
| Target General Information | Top | |||||
|---|---|---|---|---|---|---|
| Target ID |
T03006
(Former ID: TTDI01879)
|
|||||
| Target Name |
Acetylcholine release (Ach rele)
|
|||||
| Gene Name |
NO-GeName
|
|||||
| Target Type |
Successful target
|
[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Cervical cancer [ICD-11: 2C77] | |||||
| UniProt ID | ||||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Approved Drug(s) | [+] 2 Approved Drugs | + | ||||
| 1 | Abobotulinum toxin A | Drug Info | Approved | Cervical cancer | [2] | |
| 2 | Incobotulinum toxin A | Drug Info | Approved | Cervical cancer | [1], [2] | |
| Discontinued Drug(s) | [+] 2 Discontinued Drugs | + | ||||
| 1 | HOE-065 | Drug Info | Discontinued in Phase 1 | Cognitive impairment | [3] | |
| 2 | KW-6055 | Drug Info | Discontinued in Phase 1 | Inflammation | [4] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Modulator | [+] 4 Modulator drugs | + | ||||
| 1 | Abobotulinum toxin A | Drug Info | [1], [2] | |||
| 2 | Incobotulinum toxin A | Drug Info | [1], [2] | |||
| 3 | HOE-065 | Drug Info | [5] | |||
| 4 | KW-6055 | Drug Info | [6] | |||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. | |||||
| REF 2 | Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. | |||||
| REF 3 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006815) | |||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000699) | |||||
| REF 5 | Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents. Eur J Pharmacol. 1989 Nov 14;171(1):79-85. | |||||
| REF 6 | Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43. | |||||
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