Target Information
| Target General Information | Top | |||||
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| Target ID |
T01865
(Former ID: TTDR00598)
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| Target Name |
Plasmodium Hexose transporter 1 (Malaria ht1)
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| Synonyms |
ht1; Putative sugar transporter; Hexose transporter
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| Gene Name |
Malaria ht1
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| Target Type |
Literature-reported target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Malaria [ICD-11: 1F40-1F45] | |||||
| Function |
High-affinity glucose transporter.
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| UniProt ID | ||||||
| Sequence |
MTKSSKDICSENEGKKNGKSGFFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEW
CKGEKDRLNCSNNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSIL TSITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLFITFGIFVAV MLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGILALVVFFKEETPYFLFEKG RIEESKNILKKIYETDNVDEPLNAIKEAVEQNESAKKNSLSLLSALKIPSYRYVIILGCL LSGLQQFTGINVLVSNSNELYKEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTL LLWGCVGVLVAYLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFP SEIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFFIFFFIKETK GGEIGTSPYITMEERQKHMTKSVV Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: B-Nonylglucoside | Ligand Info | |||||
| Structure Description | Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose | PDB:6M20 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [2] |
| PDB Sequence |
FSTSFKYVLS
32 ACIASFIFGY42 QVSVLNTIKN52 FIVVEFEWCK62 GEKDRLNCSN72 NTIQSSFLLA 82 SVFIGAVLGC92 GFSGYLVQFG102 RRLSLLIIYN112 FFFLVSILTS122 ITHHFHTILF 132 ARLLSGFGIG142 LVTVSVPMYI152 SEMTHKDKKG162 AYGVMHQLFI172 TFGIFVAVML 182 GLAMGEGPKA192 DSTEPLTSFA202 KLWWRLMFLF212 PSVISLIGIL222 ALVVFFKEET 232 PYFLFEKGRI242 EESKNILKKI252 YETDNVDEPL262 NAIKEAVEQN272 ESAKKNSLSL 282 LSALKIPSYR292 YVIILGCLLS302 GLQQFTGINV312 LVSNSNELYK322 EFLDSHLITI 332 LSVVMTAVNF342 LMTFPAIYIV352 EKLGRKTLLL362 WGCVGVLVAY372 LPTAIANEIN 382 RNSNFVKILS392 IVATFVMIIS402 FAVSYGPVLW412 IYLHEMFPSE422 IKDSAASLAS 432 LVNWVCAIIV442 VFPSDIIIKK452 SPSILFIVFS462 VMSILTFFFI472 FFFIKETKGG 482 EIGTSPYITM492 EERQKH
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SER45
4.831
ASN48
4.138
THR49
3.252
GLU57
4.421
ILE123
4.036
HIS125
3.090
HIS128
3.198
LEU131
3.671
PHE132
3.704
ILE176
4.127
ALA179
4.648
VAL180
2.403
MET181
4.545
GLY183
3.598
LEU184
3.684
GLU188
4.274
ARG207
3.274
GLY309
3.621
ILE310
4.647
VAL312
3.694
LEU313
4.039
VAL314
3.329
SER317
3.262
ASN318
3.599
LEU320
3.177
TYR321
3.588
GLU323
3.135
PHE324
3.519
SER327
4.628
THR331
3.267
SER334
3.682
VAL335
4.965
MET337
4.071
THR338
3.703
ASN341
3.441
TYR372
3.549
THR375
4.225
ASN379
2.924
ARG383
3.043
VAL388
4.109
LYS389
3.231
SER392
2.495
THR396
3.192
MET399
3.980
ILE400
4.291
ILE450
3.836
PRO454
3.480
LEU457
4.883
PHE458
3.696
PHE461
3.545
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| Ligand Name: Beta-D-Glucose | Ligand Info | |||||
| Structure Description | Crystal structure of Plasmodium falciparum hexose transporter PfHT1 bound with glucose | PDB:6M20 | ||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [2] |
| PDB Sequence |
FSTSFKYVLS
32 ACIASFIFGY42 QVSVLNTIKN52 FIVVEFEWCK62 GEKDRLNCSN72 NTIQSSFLLA 82 SVFIGAVLGC92 GFSGYLVQFG102 RRLSLLIIYN112 FFFLVSILTS122 ITHHFHTILF 132 ARLLSGFGIG142 LVTVSVPMYI152 SEMTHKDKKG162 AYGVMHQLFI172 TFGIFVAVML 182 GLAMGEGPKA192 DSTEPLTSFA202 KLWWRLMFLF212 PSVISLIGIL222 ALVVFFKEET 232 PYFLFEKGRI242 EESKNILKKI252 YETDNVDEPL262 NAIKEAVEQN272 ESAKKNSLSL 282 LSALKIPSYR292 YVIILGCLLS302 GLQQFTGINV312 LVSNSNELYK322 EFLDSHLITI 332 LSVVMTAVNF342 LMTFPAIYIV352 EKLGRKTLLL362 WGCVGVLVAY372 LPTAIANEIN 382 RNSNFVKILS392 IVATFVMIIS402 FAVSYGPVLW412 IYLHEMFPSE422 IKDSAASLAS 432 LVNWVCAIIV442 VFPSDIIIKK452 SPSILFIVFS462 VMSILTFFFI472 FFFIKETKGG 482 EIGTSPYITM492 EERQKH
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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| Protein Name | Pfam ID | Percentage of Identity (%) | E value |
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| Solute carrier family 22 member 7 (SLC22A7) | 22.026 (50/227) | 4.52E-04 |
| Chemical Structure based Activity Landscape of Target | Top |
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| Target Poor or Non Binders | Top | |||||
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| Target Poor or Non Binders | ||||||
| References | Top | |||||
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| REF 1 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | |||||
| REF 2 | Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020 Oct 1;183(1):258-268.e12. | |||||
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