Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
References
Drug Binding Sites of Target  Top
Ligand Name: 7N-Methyl-8-hydroguanosine-5'-triphosphate Ligand Info
Structure Description Crystal structure of LARP1-unique domain DM15 bound to m7GpppC PDB:5V87
Method X-ray diffraction Resolution 1.69 Å Mutation No [2]
PDB Sequence
HMQHPSHELL
803
KEGFTQHVYH
814
KYRRRCLNER
824
KRLGIGQSQE
834
MNTLFRFWSF
844

FLRDHFNKKM
854
YEEFKQLALE
864
DAKEGYRYGL
874
ECLFRYYSYG
884
LEKKFRLDIF
894

KDFQEETVKD
904
YEAGQLYGLE
914
KFWAFLKYSK
924
AKNLDIDPKL
934
QEYLGKF
Residue
Distance (Å)
SER882
2.109
TYR883
2.985
GLU886
1.639
GLU914
1.863
LYS915
2.876
Residue
Distance (Å)
TRP917
3.782
ALA918
2.811
PHE919
3.447
TYR922
2.645
Click to View More Binding Site Information of This Target and Ligand Pair
Ligand Name: 7-Methyl-guanosine-5'-triphosphate-5'-guanosine Ligand Info
Structure Description LARP1 DM15 FYRE (F844Y, R847E) mutant bound to m7GpppG dinucleotide (capG) PDB:6PW3
Method X-ray diffraction Resolution 2.34 Å Mutation Yes [3]
PDB Sequence
HPSHELLKEN
806
GFTQHVYHKY
816
RRRCLNERKR
826
LGIGQSQEMN
836
TLFRFWSYFL
846

EDHFNKKMYE
856
EFKQLALEDA
866
KEGYRYGLEC
876
LFRYYSYGLE
886
KKFRLDIFKD
896

FQEETVKDYE
906
AGQLYGLEKF
916
WAFLKYSKAK
926
NLDIDPKLQE
936
YLGKFRRLE
Residue
Distance (Å)
ARG840
4.942
SER843
2.372
TYR844
2.842
GLU847
1.688
CYS876
4.181
ARG879
2.337
TYR880
2.949
SER882
1.951
TYR883
2.614
GLU886
1.802
Residue
Distance (Å)
LYS887
4.458
TYR911
2.605
GLU914
2.061
LYS915
2.091
TRP917
3.873
ALA918
2.332
PHE919
2.794
LYS921
4.747
TYR922
2.869
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
Degree 2 Degree centrality 2.15E-04 Betweenness centrality 4.72E-05
Closeness centrality 2.01E-01 Radiality 1.35E+01 Clustering coefficient 0.00E+00
Neighborhood connectivity 4.35E+01 Topological coefficient 5.00E-01 Eccentricity 12
Download Click to Download the Full PPI Network of This Target

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