Target Information

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Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
References
Drug Binding Sites of Target  Top
Ligand Name: GSK2982772 Ligand Info
Structure Description Rip1 Kinase ( flag 1-294, C34A, C127A, C233A, C240A) with GSK772 PDB:5TX5
Method X-ray diffraction Resolution 2.56 Å Mutation Yes [2]
PDB Sequence
IKMKSSDFLE
19
SAELDSGGKV
31
SLAFHRTQGL
41
MIMKTVYKGP
51
NCIEHNEALL
61

EEAKMMNRLR
71
HSRVVKLLGV
81
IIEEGKYSLV
91
MEYMEKGNLM
101
HVLKAEMSTP
111

LSVKGRIILE
121
IIEGMAYLHG
131
KGVIHKDLKP
141
ENILVDNDFH
151
IKIADLGLAS
161

FKMWSKLNGT
189
LYYMAPEHLN
199
DVNAKPTEKS
209
DVYSFAVVLW
219
AIFANKEPYQ
235

QLIMAIKSGN
245
RPDVDDITEY
255
CPREIISLMK
265
LCWEANPEAR
275
PTFPGIEEKF
285

RPFYLSQLE
Residue
Distance (Å)
GLY29
5.000
VAL31
3.698
ILE43
3.761
MET44
4.110
LYS45
3.646
MET67
3.632
LEU70
3.893
VAL75
3.738
VAL76
3.106
LYS77
4.551
LEU78
3.514
LEU90
3.476
Residue
Distance (Å)
VAL91
3.947
MET92
3.237
LEU129
3.816
VAL134
4.061
HIS136
3.499
ILE154
3.685
ALA155
3.682
ASP156
2.800
LEU157
3.236
LEU159
3.662
SER161
3.877
PHE162
3.390
Ligand Name: GSK3145095 Ligand Info
Structure Description Crystal structure of RIP1 kinase in complex with GSK3145095 PDB:6RLN
Method X-ray diffraction Resolution 2.87 Å Mutation Yes [3]
PDB Sequence
NVIKMKSSDF
17
LEKVSLAFHR
37
TQGLMIMKTV
47
YKGPNCIEHN
57
EALLEEAKMM
67

NRLRHSRVVK
77
LLGVIIEEGK
87
YSLVMEYMEK
97
GNLMHVLKAE
107
MSTPLSVKGR
117

IILEIIEGMA
127
YLHGKGVIHK
137
DLKPENILVD
147
NDFHIKIADL
157
GLASFKMWSK
167

LNNEEHNELG
188
TLYYMAPEHL
198
NDVNAKPTEK
208
SDVYSFAVVL
218
WAIFANKEPY
228

ENAIAEQQLI
238
MAIKSGNRPD
248
VDDITEYCPR
258
EIISLMKLCW
268
EANPEARPTF
278

PGIEEKFRPF
288
YLSQLE
Residue
Distance (Å)
VAL31
3.404
ILE43
3.458
MET44
3.386
LYS45
3.355
MET67
4.277
LEU70
3.648
VAL75
3.642
VAL76
3.358
LYS77
4.733
LEU78
3.419
LEU90
3.042
VAL91
3.970
Residue
Distance (Å)
MET92
3.345
LEU129
4.021
VAL134
3.774
HIS136
3.545
ILE154
3.766
ALA155
3.579
ASP156
2.867
LEU157
3.366
LEU159
4.497
SER161
3.542
PHE162
3.649
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Human Pathway Affiliation of target is determined by the life-essential pathways provided on KEGG database. The target-affiliated pathways were defined based on the following two criteria (a) the pathways of the studied target should be life-essential for both healthy individuals and patients, and (b) the studied target should occupy an upstream position in the pathways and therefore had the ability to regulate biological function.
Targets involved in a fewer pathways have greater likelihood to be successfully developed, while those associated with more human pathways increase the chance of undesirable interferences with other human processes (Pharmacol Rev, 58: 259-279, 2006).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Human Pathway Affiliation
Biological Network Descriptors
Protein Name Pfam ID Percentage of Identity (%) E value
PKC-delta-interacting protein kinase (RIPK4)
PF12796 ; 
PF00069
32.975 (92/279) 8.79E-35
Mixed lineage kinase 1 (MAP3K9)
PF00069 ; 
PF14604
28.179 (82/291) 7.67E-23
Checkpoint kinase-1 (CHK1)
PF00069
30.622 (64/209) 9.02E-21
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
PF00069
25.641 (80/312) 1.29E-20
Protein kinase C theta (PRKCQ)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 30.705 (74/241) 1.44E-20
Ribosomal protein S6 kinase alpha-2 (RSK2)
PF00069 ; 
PF00433
28.417 (79/278) 6.55E-20
Ribosomal protein S6 kinase alpha-3 (RSK3)
PF00069 ; 
PF00433
27.857 (78/280) 2.00E-19
ERK activator kinase 2 (MEK2)
PF00069
26.818 (59/220) 2.03E-19
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
PF00069
26.144 (80/306) 2.65E-19
Calmodulin-dependent kinase II (CAMKK2)
PF00069
30.508 (72/236) 2.77E-19
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
PF00069
27.019 (87/322) 4.91E-19
MAPK/ERK kinase kinase 3 (MAP3K3)
PF00564 ; 
PF00069
30.047 (64/213) 6.65E-19
MAPK/ERK kinase kinase 1 (MAP3K1)
PF00069
27.481 (72/262) 7.75E-19
Ribosomal protein S6 kinase alpha-1 (RSK1)
PF00069 ; 
PF00433
27.907 (72/258) 9.16E-19
Phosphoinositide dependent protein kinase-1 (PDPK1)
PF14593 ; 
PF00069
28.837 (62/215) 1.18E-18
ERK activator kinase 1 (MEK1)
PF00069
26.364 (58/220) 1.57E-18
Ribosomal protein S6 kinase alpha-6 (RSK6)
PF00069 ; 
PF00433
25.993 (72/277) 1.99E-18
Putative 3-phosphoinositide-dependent protein kinase 2 (PDPK2P)
PF00069
28.372 (61/215) 2.91E-18
MAPK/ERK kinase kinase 2 (MAP3K2)
PF00564 ; 
PF00069
30.047 (64/213) 3.51E-18
CaM-kinase IV kinase (CAMKK1)
PF00069
29.388 (72/245) 4.37E-18
ERK activator kinase 5 (MAP2K5)
PF00564 ; 
PF00069
23.443 (64/273) 9.21E-18
Microtubule affinity regulating kinase 3 (MARK3)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 26.190 (77/294) 9.34E-18
SPS1/STE20-related protein kinase YSK4 (YSK4)
PF00069
24.904 (65/261) 9.79E-18
Serine/threonine-protein kinase H1 (PSKH1)
PF00069
27.650 (60/217) 1.63E-17
Serine/threonine-protein kinase MARK1 (MARK1)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 29.245 (62/212) 1.87E-17
Serine/threonine-protein kinase Nek5 (NEK5)
PF00069
25.830 (70/271) 2.35E-17
Hormonally up-regulated neu tumor-associated kinase (HUNK)
PF00069
29.954 (65/217) 3.33E-17
Serine/threonine-protein kinase MARK2 (MARK2)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 27.586 (72/261) 4.23E-17
Serine/threonine-protein kinase 17B (STK17B)
PF00069
29.004 (67/231) 5.90E-17
Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 27.675 (75/271) 5.96E-17
Large tumor suppressor homolog 2 (LATS2)
PF00069 ; 
PF00433
25.987 (79/304) 6.53E-17
MAP/microtubule affinity-regulating kinase 4 (MARK4)
PF02149 ; 
PF00069 ; 
PF00627
More >>
 28.169 (60/213) 7.09E-17
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
PF16579 ; 
PF00069
26.354 (73/277) 7.30E-17
Serine/threonine-protein kinase SBK1 (SBK1)
PF00069
27.064 (59/218) 8.13E-17
Myosin light chain kinase 2 (MYLK2)
PF00069
30.909 (68/220) 1.09E-16
Oxidative stress responsive 1 (OXSR1)
PF12202 ; 
PF00069
26.033 (63/242) 1.25E-16
Microtubule-associated serine/threonine-protein kinase 3 (MAST3)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 29.091 (64/220) 1.42E-16
ERK activator kinase 7 (MAP2K7)
PF00069
25.658 (78/304) 1.45E-16
Aurora kinase A (AURKA)
PF00069
26.966 (72/267) 1.59E-16
Omphalocele kinase 1 (NUAK1)
PF00069
26.996 (71/263) 1.94E-16
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)
PF00069
25.000 (75/300) 2.10E-16
NIMA-related kinase 2 (NEK2)
PF00069
25.410 (62/244) 2.28E-16
Calcium/calmodulin-dependent protein kinase type 1G (CAMK1G)
PF00069
26.359 (97/368) 2.51E-16
Ste-20-related kinase (STK39)
PF12202 ; 
PF00069
25.758 (68/264) 2.94E-16
Salt-inducible kinase 2 (SIK2)
PF00069
27.885 (58/208) 3.43E-16
NIMA-related kinase 7 (NEK7)
PF00069
23.509 (67/285) 3.47E-16
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
PF16579 ; 
PF00069
26.354 (73/277) 4.11E-16
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1)
PF00069
26.772 (68/254) 4.12E-16
Serine/threonine-protein kinase Nek3 (NEK3)
PF00069
24.723 (67/271) 4.81E-16
BR serine/threonine kinase 1 (BRSK1)
PF00069
26.007 (71/273) 4.88E-16
Microtubule-associated serine/threonine-protein kinase 2 (MAST2)
PF08926 ; 
PF17820 ; 
PF00069
More >>
 29.130 (67/230) 5.13E-16
Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4)
PF12745 ; 
PF00069 ; 
PF05773 ; 
PF13393
More >>
 28.643 (57/199) 5.57E-16
Microtubule-associated serine/threonine-protein kinase 4 (MAST4)
PF08926 ; 
PF17820 ; 
PF02163 ; 
PF00069
More >>
 27.206 (74/272) 6.03E-16
Serine/threonine-protein kinase Nek11 (NEK11)
PF00069
25.159 (79/314) 6.18E-16
Myosin light chain kinase 3 (MYLK3)
PF00069
31.604 (67/212) 7.86E-16
Testis-specific serine/threonine-protein kinase 4 (TSSK4)
PF00069
23.171 (57/246) 8.52E-16
Serine/threonine-protein kinase STK11 (STK11)
PF00069
30.058 (52/173) 1.04E-15
Serine/threonine-protein kinase MAK (MAK)
PF00069
28.216 (68/241) 1.09E-15
MAPK/ERK kinase kinase 4 (MAP3K4)
PF19431 ; 
PF00069
25.954 (68/262) 1.14E-15
Rhodopsin kinase GRK1 (GRK1)
PF00069 ; 
PF00615
28.829 (64/222) 1.59E-15
Serine/threonine-protein kinase 32A (STK32A)
PF00069
26.336 (69/262) 1.62E-15
Serine/threonine-protein kinase LATS1 (LATS1)
PF00069 ; 
PF00627
25.000 (81/324) 1.79E-15
Protein kinase C beta (PRKCB)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 27.586 (64/232) 1.97E-15
Proto-oncogene serine/threonine-protein kinase mos (MOS)
PF00069
24.823 (70/282) 2.14E-15
Aurora kinase C (AURKC)
PF00069
27.111 (61/225) 2.20E-15
Maternal embryonic leucine zipper kinase (MELK)
PF02149 ; 
PF00069
25.481 (53/208) 2.73E-15
Protein kinase C delta (PRKCD)
PF00130 ; 
PF00069 ; 
PF00433
More >>
 26.282 (82/312) 4.40E-15
Phosphorylase kinase testis gamma 2 (PHKG2)
PF00069
25.660 (68/265) 6.18E-15
Serine/threonine-protein kinase 10 (STK10)
PF00069 ; 
PF12474
25.993 (72/277) 6.27E-15
NIMA-related kinase 1 (NEK1)
PF00069
24.542 (67/273) 6.34E-15
BR serine/threonine kinase 2 (BRSK2)
PF00069
25.940 (69/266) 6.95E-15
Serine/threonine-protein kinase 3 (STK3)
PF11629 ; 
PF00069
26.316 (70/266) 6.99E-15
Myosin light chain kinase family member 4 (MYLK4)
PF00069
31.019 (67/216) 7.58E-15
NIMA-related kinase 6 (NEK6)
PF00069
24.727 (68/275) 8.08E-15
Testis-specific serine kinase 2 (TSSK2)
PF00069
22.414 (52/232) 8.31E-15
RAC-gamma serine/threonine-protein kinase (AKT3)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 27.602 (61/221) 8.35E-15
RAC-beta serine/threonine-protein kinase (AKT2)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 26.724 (62/232) 8.56E-15
Serine/threonine-protein kinase ICK (CILK1)
PF00069
30.288 (63/208) 1.14E-14
Protein kinase C alpha (PRKCA)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 28.511 (67/235) 1.55E-14
Doublecortin-like kinase 2 (DCLK2)
PF03607 ; 
PF00069
24.528 (65/265) 1.67E-14
Serine/threonine-protein kinase Chk2 (RAD53)
PF00498 ; 
PF00069
26.132 (75/287) 1.80E-14
Serine/threonine-protein kinase Sgk1 (SGK1)
PF00069 ; 
PF00433
28.054 (62/221) 1.91E-14
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
PF00069
30.612 (45/147) 2.25E-14
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
PF00069
30.120 (50/166) 2.31E-14
MST-1 protein kinase (STK4)
PF11629 ; 
PF00069
24.928 (86/345) 2.82E-14
Serine/threonine-protein kinase ULK2 (ULK2)
PF12063 ; 
PF00069
28.947 (66/228) 3.31E-14
Cyclin-dependent kinase 2 (CDK2)
PF00069
25.200 (63/250) 3.44E-14
Aurora kinase B (AURKB)
PF00069
27.727 (61/220) 3.74E-14
NUAK family SNF1-like kinase 2 (NUAK2)
PF00069
25.373 (68/268) 3.82E-14
Testis-specific serine/threonine-protein kinase 3 (TSSK3)
PF00069
28.994 (49/169) 5.26E-14
Cyclin-dependent kinase-like 5 (CDKL5)
PF00069
29.442 (58/197) 5.74E-14
Calcium/calmodulin-dependent protein kinase type 1B (PNCK)
PF00069
25.568 (90/352) 5.78E-14
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)
PF08332 ; 
PF00069
26.493 (71/268) 7.26E-14
Stress-activated protein kinase 2a (p38 alpha)
PF00069
24.783 (57/230) 7.63E-14
Serine/threonine-protein kinase Nek4 (NEK4)
PF00069
28.090 (75/267) 7.71E-14
Serine/threonine-protein kinase Nek9 (NEK9)
PF00069 ; 
PF00415
25.672 (86/335) 8.97E-14
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
PF08332 ; 
PF00069
25.141 (89/354) 9.47E-14
Bone morphogenetic protein receptor (BMPR2)
PF01064 ; 
PF00069
27.863 (73/262) 9.69E-14
Polo-like kinase 1 (PLK1)
PF00069 ; 
PF00659
24.033 (87/362) 1.06E-13
Ribosomal protein S6 kinase beta-1 (S6K1)
PF00069 ; 
PF00433
26.852 (58/216) 1.06E-13
Serine/threonine-protein kinase 32C (STK32C)
PF00069
25.475 (67/263) 1.07E-13
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
PF08332 ; 
PF00069
26.740 (73/273) 1.13E-13
Putative serine/threonine-protein kinase PRKY (PRKY)
PF00069
30.714 (43/140) 1.14E-13
Serine/threonine-protein kinase ULK1 (ULK1)
PF12063 ; 
PF00069
29.787 (56/188) 1.19E-13
Tyrosine-protein kinase EIF2AK2 (p68)
PF00035 ; 
PF00069
24.839 (77/310) 1.20E-13
Serine/threonine-protein kinase PLK3 (PLK3)
PF00069 ; 
PF00659
26.293 (61/232) 1.31E-13
G protein-coupled receptor kinase 6 (GRK6)
PF00069 ; 
PF00615
29.817 (65/218) 1.34E-13
Death-associated protein kinase 2 (DAPK2)
PF00069
29.386 (67/228) 1.34E-13
Serine/threonine-protein kinase Nek8 (NEK8)
PF00069 ; 
PF00415
24.332 (82/337) 1.45E-13
Serine/threonine-protein kinase 26 (STK26)
PF00069
25.188 (67/266) 1.46E-13
SIK family kinase 3 (SIK3)
PF00069
25.352 (54/213) 1.51E-13
Protein kinase C eta type (PRKCH)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 25.714 (54/210) 1.64E-13
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1)
PF12796 ; 
PF16095 ; 
PF00069 ; 
PF08477
More >>
 28.761 (65/226) 1.70E-13
Cyclin-dependent kinase 1 (CDK1)
PF00069
25.207 (61/242) 1.92E-13
Doublecortin-like kinase 3 (DCLK3)
PF00069
25.333 (57/225) 2.22E-13
Rho-associated protein kinase 1 (ROCK1)
PF00069 ; 
PF08912
25.517 (74/290) 2.33E-13
Doublecortin-like kinase 1 (DCLK1)
PF03607 ; 
PF00069
22.441 (57/254) 2.47E-13
Serine/threonine-protein kinase H2 (PSKH2)
PF00069
26.728 (58/217) 2.48E-13
Cytoplasmic DRAK1 (STK17A)
PF00069
27.451 (84/306) 2.53E-13
Mitogen-activated protein kinase kinase kinase 15 (MAP3K15)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 26.860 (65/242) 2.54E-13
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)
PF00069
26.398 (85/322) 2.74E-13
RAC-alpha serine/threonine-protein kinase (AKT1)
PF00169 ; 
PF00069 ; 
PF00433
More >>
 28.436 (60/211) 2.95E-13
Myosin light kinase (MYLK)
PF16620 ; 
PF00041 ; 
PF07679 ; 
PF00069
More >>
 27.602 (61/221) 3.04E-13
Extracellular signal-regulated kinase 5 (ERK5)
PF00069
23.305 (55/236) 3.54E-13
MEK kinase kinase 3 (MAP4K3)
PF00780 ; 
PF00069
24.232 (71/293) 3.61E-13
Anti-mullerian hormone II receptor (AMHR2)
PF00069
26.778 (64/239) 6.41E-13
SNF-related serine/threonine-protein kinase (SNRK)
PF00069
23.774 (63/265) 6.91E-13
Cyclin-dependent kinase 3 (CDK3)
PF00069
29.940 (50/167) 7.00E-13
Inhibitor of nuclear factor kappa-B kinase alpha (IKKA)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 31.507 (69/219) 7.60E-13
G protein-coupled receptor kinase 4 (GRK4)
PF00069 ; 
PF00615
30.047 (64/213) 8.53E-13
TAO kinase 1 (TAOK1)
PF00069
26.484 (58/219) 8.96E-13
Homeodomain-interacting protein kinase 4 (HIPK4)
PF00069
27.897 (65/233) 9.11E-13
Testis-specific serine/threonine-protein kinase 1 (TSSK1B)
PF00069
23.707 (55/232) 9.39E-13
Serine/threonine-protein kinase WNK1 (WNK1)
PF12202 ; 
PF00069
28.505 (61/214) 9.46E-13
Polo-like kinase 4 (PLK4)
PF00069 ; 
PF18190 ; 
PF18409
More >>
 28.409 (50/176) 1.14E-12
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)
PF08332 ; 
PF00069
27.049 (66/244) 1.25E-12
G protein-coupled receptor kinase 5 (GRK5)
PF00069 ; 
PF00615
29.358 (64/218) 1.43E-12
Calcium/calmodulin-dependent protein kinase type IV (CAMK4)
PF00069
28.311 (62/219) 1.51E-12
Activin receptor type IB (ACVR1B)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 29.670 (81/273) 1.68E-12
Serine/threonine-protein kinase 33 (STK33)
PF00069
26.724 (62/232) 1.75E-12
Cyclin-dependent kinase 16 (CDK16)
PF12330 ; 
PF00069
23.984 (59/246) 1.80E-12
Serine/threonine-protein kinase PAK 5 (PAK5)
PF00786 ; 
PF00069
24.242 (48/198) 1.94E-12
Polo-like kinase 2 (PLK2)
PF00069 ; 
PF00659
23.970 (64/267) 1.94E-12
Serine/threonine-protein kinase Sgk2 (SGK2)
PF00069 ; 
PF00433
26.606 (58/218) 1.94E-12
Apoptosis signal-regulating kinase 1 (MAP3K5)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 25.778 (58/225) 2.02E-12
Protein kinase C epsilon (PRKCE)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 24.806 (64/258) 2.09E-12
Serine/threonine-protein kinase TAO2 (TAOK2)
PF00069
25.571 (56/219) 2.10E-12
MAP kinase p38 (MAPK12)
PF00069
24.783 (57/230) 2.88E-12
Serine/threonine-protein kinase WNK4 (WNK4)
PF12202 ; 
PF00069
27.700 (59/213) 2.94E-12
TAO kinase 3 (TAOK3)
PF00069
25.461 (69/271) 3.18E-12
Unc-51 like kinase 3 (ULK3)
PF04212 ; 
PF00069
25.346 (55/217) 3.25E-12
Stress-activated protein kinase 2b (p38 beta)
PF00069
23.932 (56/234) 3.35E-12
TGF-beta receptor type I (TGFBR1)
PF01064 ; 
PF00069 ; 
PF08515
More >>
 28.938 (79/273) 3.91E-12
PAK-4 protein kinase (PAK4)
PF00786 ; 
PF00069
24.432 (43/176) 4.22E-12
Serine/threonine-protein kinase 24 (STK24)
PF00069
24.719 (66/267) 4.40E-12
Extracellular signal-regulated kinase 1 (ERK1)
PF00069
24.519 (51/208) 6.05E-12
Serine/threonine-protein kinase 35 (STK35)
PF00069
24.870 (48/193) 6.18E-12
Rho-associated protein kinase 2 (ROCK2)
PF00069 ; 
PF08912
26.009 (58/223) 6.21E-12
Cyclin-dependent kinase-like 3 (CDKL3)
PF00069
29.167 (42/144) 6.99E-12
Ribosomal protein S6 kinase beta-2 (RPS6KB2)
PF00069 ; 
PF00433
26.852 (58/216) 7.09E-12
Serine/threonine-protein kinase 25 (STK25)
PF00069
23.451 (53/226) 7.20E-12
Protein kinase C gamma (PRKCG)
PF00130 ; 
PF00168 ; 
PF00069 ; 
PF00433
More >>
 26.201 (60/229) 7.54E-12
Cyclin-dependent kinase-like 2 (CDKL2)
PF00069
22.319 (77/345) 7.68E-12
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
PF00780 ; 
PF00069
25.000 (55/220) 7.70E-12
Salt-inducible kinase 1 (SIK1)
PF00069
24.762 (52/210) 7.73E-12
Putative serine/threonine-protein kinase SIK1B (SIK1B)
PF00069
24.762 (52/210) 7.86E-12
BMP-2-inducible protein kinase (BMP2K)
PF15282 ; 
PF00069
27.341 (73/267) 8.32E-12
Ribosomal protein S6 kinase alpha-5 (RSK5)
PF00069 ; 
PF00433
29.012 (47/162) 1.03E-11
Cyclin-dependent kinase 17 (CDK17)
PF12330 ; 
PF00069
23.140 (56/242) 1.12E-11
Apoptosis signal-regulating kinase 2 (MAP3K6)
PF19039 ; 
PF20309 ; 
PF20302 ; 
PF13281 ; 
PF00069
More >>
 26.404 (47/178) 1.18E-11
Extracellular signal-regulated kinase 2 (ERK2)
PF00069
27.059 (46/170) 1.20E-11
Yet another novel kinase 2 (STK32B)
PF00069
26.977 (58/215) 1.28E-11
Cyclin-dependent kinase 19 (CDK19)
PF00069
26.721 (66/247) 1.29E-11
Serine/threonine-protein kinase Sgk3 (SGK3)
PF00069 ; 
PF00433 ; 
PF00787
More >>
 25.455 (56/220) 1.34E-11
Protein kinase G1 (PRKG1)
PF00027 ; 
PF16808 ; 
PF00069
More >>
 26.457 (59/223) 1.48E-11
Death-associated protein kinase 3 (DAPK3)
PF00069
26.267 (57/217) 1.92E-11
WNK lysine-deficient protein kinase 3 (WNK3)
PF12202 ; 
PF00069
27.985 (75/268) 2.04E-11
Citron Rho-interacting kinase (CIT)
PF00780 ; 
PF00169 ; 
PF00069
More >>
 27.074 (62/229) 2.25E-11
STE20-related serine/threonine-protein kinase (SLK)
PF00069 ; 
PF12474
23.799 (109/458) 2.29E-11
Cyclin-dependent kinase 7 (CDK7)
PF00069
28.743 (48/167) 2.42E-11
Serine/threonine-protein kinase MRCK gamma (CDC42BPG)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF00069
More >>
 25.333 (57/225) 2.45E-11
PAS domain-containing serine/threonine-protein kinase (PASK)
PF13426 ; 
PF00069
26.347 (44/167) 2.56E-11
cAMP-dependent protein kinase catalytic subunit gamma (PRKACG)
PF00069
26.364 (58/220) 3.12E-11
Serine/threonine-protein kinase tousled-like 2 (TLK2)
PF00069
27.568 (51/185) 3.28E-11
Cyclin-dependent kinase-like 1 (CDKL1)
PF00069
26.573 (38/143) 3.29E-11
Leucine-rich repeat kinase 2 (LRRK2)
PF16095 ; 
PF12799 ; 
PF13855 ; 
PF00069 ; 
PF08477
More >>
 29.362 (69/235) 3.95E-11
Beta-adrenergic receptor kinase 1 (ADRBK1)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 27.313 (62/227) 4.42E-11
Cyclin-dependent kinase 4 (CDK4)
PF00069
26.407 (61/231) 4.72E-11
MEK kinase kinase 2 (MAP4K2)
PF00780 ; 
PF00069
25.610 (63/246) 5.29E-11
MEK kinase kinase 1 (MAP4K1)
PF00780 ; 
PF00069
24.255 (57/235) 5.65E-11
Cyclin-dependent kinase 18 (CDK18)
PF00069
26.250 (42/160) 5.71E-11
Glycogen synthase kinase-3 alpha (GSK-3A)
PF00069
26.829 (55/205) 6.77E-11
Serine/threonine-protein kinase SBK2 (SBK2)
PF00069
25.561 (57/223) 7.25E-11
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)
PF00069
25.688 (56/218) 7.73E-11
Protein kinase C iota (PRKCI)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 25.943 (55/212) 8.95E-11
Cyclin-dependent kinase 8 (CDK8)
PF00069
28.736 (50/174) 9.75E-11
TBC domain-containing protein kinase-like protein (TBCK)
PF00069 ; 
PF00566 ; 
PF00581
More >>
 23.053 (74/321) 1.01E-10
Cyclin-dependent kinase-like 4 (CDKL4)
PF00069
27.660 (39/141) 1.57E-10
Serine/threonine-protein kinase NIM1 (NIM1K)
PF00069
24.597 (61/248) 1.68E-10
Cyclin-dependent kinase 5 (CDK5)
PF00069
27.000 (27/100) 1.68E-10
Protein kinase G2 (PRKG2)
PF00027 ; 
PF00069
22.308 (58/260) 1.71E-10
Serine/threonine-protein kinase D2 (PRKD2)
PF00130 ; 
PF00069
27.962 (59/211) 1.94E-10
Cyclin-dependent kinase 6 (CDK6)
PF00069
26.923 (49/182) 2.07E-10
Serine/threonine-protein kinase PDIK1L (PDIK1L)
PF00069
24.870 (48/193) 2.23E-10
Fused homolog (STK36)
PF13646 ; 
PF00069
25.882 (44/170) 2.43E-10
PRKR-like endoplasmic reticulum kinase (PERK)
PF00069
33.036 (37/112) 2.61E-10
PDZ binding kinase (PBK)
PF00069
23.485 (62/264) 2.92E-10
PAK-2 protein kinase (PAK2)
PF00786 ; 
PF00069
23.394 (51/218) 2.93E-10
Serine/threonine-protein kinase tousled-like 1 (TLK1)
PF00069
28.649 (53/185) 3.22E-10
Serine/threonine-protein kinase greatwall (MASTL)
PF00069
29.677 (46/155) 3.69E-10
NDR2 protein kinase (STK38L)
PF00069 ; 
PF00433
23.270 (37/159) 3.74E-10
Myotonin-protein kinase (DMPK)
PF08826 ; 
PF00069
23.504 (55/234) 4.00E-10
Cyclin-dependent kinase 12 (CDK12)
PF00069
26.364 (58/220) 4.63E-10
Mitogen-activated protein kinase 6 (MAPK6)
PF00069
29.878 (49/164) 4.64E-10
Stress-activated protein kinase JNK2 (JNK2)
PF00069
30.345 (44/145) 6.15E-10
Triple functional domain protein (TRIO)
PF00650 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00018 ; 
PF00435
More >>
 25.830 (70/271) 6.15E-10
Ribosomal protein S6 kinase-related protein (RSKR)
PF00069
27.976 (47/168) 6.64E-10
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)
PF00069
26.066 (55/211) 7.03E-10
Beta-adrenergic receptor kinase 2 (ADRBK2)
PF00169 ; 
PF00069 ; 
PF00615
More >>
 26.432 (60/227) 7.78E-10
MAP kinase signal-integrating kinase 2 (MKNK2)
PF00069
26.244 (58/221) 8.02E-10
Stress-activated protein kinase JNK3 (JNK3)
PF00069
28.729 (52/181) 8.96E-10
NDR1 protein kinase (STK38)
PF00069 ; 
PF00433
23.270 (37/159) 9.14E-10
Cyclin-dependent kinase 14 (CDK14)
PF00069
30.769 (32/104) 9.30E-10
Cyclin-dependent kinase 15 (CDK15)
PF00069
25.806 (40/155) 1.06E-09
Striated muscle preferentially expressed protein kinase (SPEG)
PF07679 ; 
PF00069 ; 
PF16650
More >>
 25.806 (56/217) 1.10E-09
Protein kinase N2 (PKN2)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.737 (76/274) 1.24E-09
Serine/threonine-protein kinase PAK 6 (PAK6)
PF00786 ; 
PF00069
21.839 (38/174) 1.30E-09
Cyclin-dependent kinase 10 (CDK10)
PF00069
39.048 (41/105) 1.33E-09
Nik-related protein kinase (NRK)
PF00780 ; 
PF00069
24.454 (56/229) 1.50E-09
Misshapen-like kinase 1 (MINK1)
PF00780 ; 
PF00069
23.894 (54/226) 1.73E-09
Cyclin-dependent kinase 13 (CDK13)
PF12330 ; 
PF00069
27.684 (49/177) 1.73E-09
Peripheral plasma membrane protein CASK (CASK)
PF00625 ; 
PF02828 ; 
PF00595 ; 
PF00069 ; 
PF00018
More >>
 25.688 (56/218) 1.97E-09
Mitogen-activated protein kinase 13 (MAPK13)
PF00069
22.541 (55/244) 2.01E-09
PAK-1 protein kinase (PAK1)
PF00786 ; 
PF00069
25.434 (44/173) 2.17E-09
Serine/threonine-protein kinase PAK 3 (PAK3)
PF00786 ; 
PF00069
25.434 (44/173) 2.21E-09
Protein kinase D (PRKD1)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 27.488 (58/211) 2.30E-09
TRAF2 and NCK interacting kinase (TNIK)
PF00780 ; 
PF00069
25.214 (59/234) 2.52E-09
Stress-activated protein kinase JNK1 (JNK1)
PF00069
28.177 (51/181) 2.59E-09
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
PF00069 ; 
PF00433
25.333 (57/225) 2.91E-09
Protein kinase C zeta (PRKCZ)
PF00130 ; 
PF00564 ; 
PF00069 ; 
PF00433
More >>
 27.857 (39/140) 2.95E-09
Mitogen-activated protein kinase 4 (MAPK4)
PF00069
25.738 (61/237) 2.96E-09
Cyclin-dependent kinase 9 (CDK9)
PF00069
28.061 (55/196) 3.40E-09
Protein kinase N1 (PKN1)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 27.839 (76/273) 3.82E-09
Dual specificity protein kinase TTK (MPS1)
PF00069
24.643 (69/280) 4.47E-09
Serine/threonine-protein kinase NLK (NLK)
PF00069
21.875 (49/224) 6.08E-09
Adaptor-associated kinase 1 (AAK1)
PF00069
26.042 (50/192) 6.38E-09
Testis-specific serine/threonine-protein kinase 6 (TSSK6)
PF00069
25.110 (57/227) 8.20E-09
Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
PF18397 ; 
PF12179 ; 
PF00069
More >>
 28.378 (63/222) 8.37E-09
Serine/threonine-protein kinase D3 (PRKD3)
PF00130 ; 
PF00169 ; 
PF00069
More >>
 26.887 (57/212) 9.38E-09
Rhodopsin kinase GRK7 (GRK7)
PF00069 ; 
PF00615
25.455 (56/220) 1.10E-08
Serine/threonine-protein kinase NIK (MAP3K14)
PF00069
25.123 (51/203) 1.12E-08
Mitogen-activated protein kinase 15 (MAPK15)
PF00069
22.917 (55/240) 1.15E-08
Glycogen synthase kinase-3 beta (GSK-3B)
PF00069
24.878 (51/205) 2.29E-08
Serine/threonine-protein kinase MRCK beta (CDC42BPB)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069
More >>
 25.110 (57/227) 2.33E-08
Serine/threonine-protein kinase WNK2 (WNK2)
PF12202 ; 
PF00069
28.497 (55/193) 2.84E-08
Serine/threonine-protein kinase cot (COT)
PF00069
25.279 (68/269) 5.90E-08
MAPK-activated protein kinase 3 (MAPKAPK3)
PF00069
25.000 (54/216) 6.70E-08
TGF-beta-stimulated factor 1 (STK16)
PF00069
25.316 (60/237) 8.72E-08
CDC42 binding protein kinase alpha (DMPK-like alpha)
PF00130 ; 
PF00780 ; 
PF08826 ; 
PF15796 ; 
PF00069 ; 
PF00433
More >>
 23.348 (53/227) 9.19E-08
Kalirin (KALRN)
PF13716 ; 
PF00041 ; 
PF07679 ; 
PF00169 ; 
PF00069 ; 
PF00621 ; 
PF16609 ; 
PF00435
More >>
 23.721 (51/215) 9.57E-08
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 26.540 (56/211) 1.16E-07
Endoplasmic reticulum to nucleus signaling 1 (ERN1)
PF00069 ; 
PF06479
23.868 (58/243) 1.25E-07
Homeodomain-interacting protein kinase 1 (HIPK1)
PF00069
26.415 (56/212) 1.30E-07
Wee1-like protein kinase (WEE1)
PF00069
21.959 (65/296) 1.72E-07
Serine/threonine-protein kinase Nek10 (NEK10)
PF00069
25.751 (60/233) 2.01E-07
STE20-related kinase adapter protein beta (STRADB)
PF00069
21.395 (46/215) 2.39E-07
MEK kinase kinase 4 (MAP4K4)
PF00780 ; 
PF00069
26.347 (44/167) 3.40E-07
Serine/threonine-protein kinase ULK4 (ULK4)
PF00069
24.171 (51/211) 5.46E-07
Cyclin-dependent kinase 20 (CDK20)
PF00069
31.776 (34/107) 5.76E-07
Activin receptor type IIA (ACVR2A)
PF01064 ; 
PF00069
22.907 (52/227) 5.91E-07
Serine/threonine-protein kinase/endoribonuclease IRE2 (ERN2)
PF00069 ; 
PF06479
21.635 (45/208) 6.50E-07
Activin receptor type IIB (ACVR2B)
PF01064 ; 
PF00069
22.467 (51/227) 7.14E-07
CaM kinase-like vesicle-associated protein (CAMKV)
PF00069
19.331 (52/269) 7.68E-07
Cyclin-G-associated kinase (GAK)
PF00069 ; 
PF10409
26.396 (52/197) 7.85E-07
Homeodomain interacting protein kinase 2 (HIPK2)
PF00069
26.887 (57/212) 1.19E-06
Homeodomain-interacting protein kinase 3 (HIPK3)
PF00069
26.126 (58/222) 1.29E-06
Myosin-IIIa (MYO3A)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 27.041 (53/196) 1.78E-06
Obscurin (OBSCN)
PF00041 ; 
PF07679 ; 
PF00612 ; 
PF00069 ; 
PF00621
More >>
 21.395 (46/215) 1.99E-06
Cyclin-dependent kinase 11B (CDK11B)
PF00069
27.907 (48/172) 2.30E-06
MAPK-activated protein kinase 5 (MAPKAPK5)
PF00069
23.013 (55/239) 3.25E-06
MAPK/MAK/MRK overlapping kinase (MOK)
PF00069
27.108 (45/166) 4.72E-06
Sugen kinase 110 (SBK3)
PF00069
25.352 (36/142) 6.94E-06
Cyclin-dependent kinase 11A (CDK11A)
PF00069
27.326 (47/172) 1.51E-05
SRSF protein kinase 2 (SRPK2)
PF00069
28.000 (42/150) 1.79E-05
NF-kappa-B-activating kinase (TBK1)
PF00069 ; 
PF18394 ; 
PF18396
More >>
 26.452 (41/155) 2.04E-05
Membrane-associated kinase (PKMYT1)
PF00069
23.396 (62/265) 2.37E-05
PIM-3 protein kinase (PIM3)
PF00069
22.846 (61/267) 2.41E-05
Ribosomal protein S6 kinase delta-1 (RPS6KC1)
PF04212 ; 
PF00069 ; 
PF00787
More >>
 25.000 (54/216) 2.83E-05
Casein kinase II alpha prime (CSNK2A2)
PF00069
23.404 (33/141) 3.53E-05
Casein kinase II alpha (CSNK2A1)
PF00069
26.126 (29/111) 3.98E-05
CDC-like kinase 3 (CLK3)
PF00069
23.600 (59/250) 4.07E-05
MAPK-activated protein kinase 2 (MAPKAPK2)
PF00069
25.694 (37/144) 4.99E-05
Wee1-like protein kinase 2 (WEE2)
PF00069
22.973 (68/296) 5.29E-05
CDC-like kinase 4 (CLK4)
PF00069
22.857 (56/245) 6.44E-05
Serine/threonine-protein kinase pim-1 (PIM1)
PF00069
21.698 (46/212) 7.19E-05
Myosin-IIIb (MYO3B)
PF00612 ; 
PF00063 ; 
PF00069
More >>
 22.785 (36/158) 8.74E-05
MAPK signal-integrating kinase 1 (MKNK1)
PF00069
33.019 (35/106) 1.27E-04
Casein kinase II subunit alpha 3 (CSNK2A3)
PF00069
25.225 (28/111) 1.29E-04
SRSF protein kinase 1 (SRPK1)
PF00069
28.571 (40/140) 1.31E-04
CDC-like kinase 1 (CLK1)
PF00069
24.107 (54/224) 1.60E-04
Casein kinase I delta (CSNK1D)
PF00069
23.636 (52/220) 1.61E-04
Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
PF00069
25.668 (48/187) 1.87E-04
Dual-specificity tyrosine-phosphorylation regulated kinase 4 (DYRK4)
PF00069
25.166 (38/151) 2.98E-04
SRSF protein kinase 3 (SRPK3)
PF00069
25.899 (36/139) 3.17E-04
Casein kinase I epsilon (CSNK1E)
PF00069
21.831 (62/284) 3.95E-04
Tribbles homolog 2 (TRIB2)
PF00069
19.497 (31/159) 4.07E-04
Protein kinase N3 (PKN3)
PF02185 ; 
PF00069 ; 
PF00433
More >>
 23.750 (57/240) 7.66E-04
Tribbles homolog 1 (TRIB1)
PF00069
20.000 (32/160) 8.04E-04
Serine/threonine-protein kinase pim-2 (PIM2)
PF00069
21.605 (35/162) 1.00E-03
SCY1-like protein 2 (SCYL2)
PF00069
25.146 (43/171) 2.00E-03
Casein kinase I alpha (CSNK1A1)
PF00069
22.857 (64/280) 2.00E-03
STE20-related kinase adapter protein alpha (STRADA)
PF00069
20.442 (37/181) 3.00E-03
Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B)
PF00069
28.834 (47/163) 3.00E-03
Ribosomal protein S6 kinase-like 1 (RPS6KL1)
PF04212 ; 
PF00069
28.846 (30/104) 4.00E-03
Serine/threonine-protein kinase Kist (UHMK1)
PF00069 ; 
PF00076
27.358 (29/106) 4.00E-03
Casein kinase I gamma-2 (CSNK1G2)
PF12605 ; 
PF00069
36.000 (27/75) 5.00E-03
  Click to Show/Hide the Information of Human Similarity Proteins
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
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KEGG Pathway Pathway ID Affiliated Target Pathway Map
NF-kappa B signaling pathway hsa04064 Affiliated Target
  Class: Environmental Information Processing => Signal transduction Pathway Hierarchy
Apoptosis hsa04210 Affiliated Target
  Class: Cellular Processes => Cell growth and death Pathway Hierarchy
Necroptosis hsa04217 Affiliated Target
  Class: Cellular Processes => Cell growth and death Pathway Hierarchy
Toll-like receptor signaling pathway hsa04620 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
NOD-like receptor signaling pathway hsa04621 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
RIG-I-like receptor signaling pathway hsa04622 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
Cytosolic DNA-sensing pathway hsa04623 Affiliated Target
  Class: Organismal Systems => Immune system Pathway Hierarchy
TNF signaling pathway hsa04668 Affiliated Target
  Class: Environmental Information Processing => Signal transduction Pathway Hierarchy
  Click to Show/Hide the Information of Affiliated Human Pathways
Degree 52 Degree centrality 5.59E-03 Betweenness centrality 1.07E-03
Closeness centrality 2.48E-01 Radiality 1.43E+01 Clustering coefficient 2.30E-01
Neighborhood connectivity 3.15E+01 Topological coefficient 5.10E-02 Eccentricity 11
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