Target General Information
Target ID T93653 Target Info
Target Name Cathepsin V (CTSV)
Synonyms UNQ268/PRO305; Cathepsin U; Cathepsin L2; CTSU; CTSL2; CATL2
Target Type Patented-recorded Target
Gene Name CTSV
Biochemical Class Peptidase
UniProt ID
Patent(s) and the Corresponding Patented Drug(s)
World Intellectual Property Organization (WIPO)
Patent ID WO2012151319
Title Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain.
Abstract The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.
Applicant(s) Virobay, Inc. Booth, Robert
Representative Drug(s) D06XCD Drug Info IC50 = 0.25 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US8680152
Title Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain.
Representative Drug(s) D06XCD Drug Info IC50 = 0.25 nM [1]
Patent ID US20120282267
Title Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain.
Representative Drug(s) D06XCD Drug Info IC50 = 0.25 nM [1]
References
REF 1 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.

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