Target General Information
Target ID T77236 Target Info
Target Name Cathepsin F (CTSF)
Synonyms CATSF
Target Type Patented-recorded Target
Gene Name CTSF
Biochemical Class Peptidase
UniProt ID
Patent(s) and the Corresponding Patented Drug(s)
World Intellectual Property Organization (WIPO)
Patent ID WO2012151319
Title Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain.
Abstract The present invention is directed to methods of using compounds that are inhibitors of cysteine proteases, in particular, of both cathepsins S and K and optionally further cathepsins B and/or L in treating bone cancer. The present invention is directed to pharmaceutical compositions comprising these compounds for treating bone cancer and bone cancer pain, especially the pain associated with metastasis. A single compound can be used to ameliorate the pain, the injury to bone, while also reducing tumor growth, the risk of metastasis and/or invasiveness of the cancer.
Applicant(s) Virobay, Inc. Booth, Robert
Representative Drug(s) D06XCD Drug Info IC50 = 4.7 nM [1]
Patent ID WO2010056877
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US8680152
Title Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain.
Representative Drug(s) D06XCD Drug Info IC50 = 4.7 nM [1]
Patent ID US20120282267
Title Cathepsin Inhibitors for The Treatment of Bone Cancer and Bone Cancer Pain.
Representative Drug(s) D06XCD Drug Info IC50 = 4.7 nM [1]
European Patent Office (EPO)
Patent ID EP2361243
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
Japan Patent Office (JPO)
Patent ID JP5540004
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
Patent ID JP2012508758
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
China National Intellectual Property Administration (CNIPA)
Patent ID CN102264695
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
Intellectual Property Office in India (IP India)
Patent ID IN2011KN02004
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
Canadian Intellectual Property Office (CIPO)
Patent ID CA2743749
Title Preparation of Fluoroalkyl Amino Acid Amides As Inhibitors of Cathepsin B, K, L, F, or S.
Representative Drug(s) D05OIU Drug Info Ki < 100 nM [1]
References
REF 1 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.

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