Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D1JS9X
|
|||
| Drug Name |
ABTAA
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Sepsis [ICD-11: 1G40-1G41; ICD-9: 995.91] | Investigative | [1] | |
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Angiopoietin 1 receptor (TEK) | Target Info | Activator | [1] |
| Angiopoietin-2 (ANGPT2) | Target Info | Binder | [1] | |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| HIF-1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Wnt Signaling Pathway | ||||
| Panther Pathway | Angiogenesis | |||
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling | |||
| SHP2 signaling | ||||
| Reactome | Tie2 Signaling | |||
| RAF/MAP kinase cascade | ||||
| WikiPathways | Cell surface interactions at the vascular wall | |||
| Wnt Signaling Pathway Netpath | ||||
| Angiogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 2016 Apr 20;8(335):335ra55. | |||
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