Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Z9DY
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| Former ID |
DNC009374
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| Drug Name |
2-phenylquinoline-8-carboxamide
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| Synonyms |
2-phenylquinoline-8-carboxamide; CHEMBL480429; SCHEMBL6442515; ZINC3939668
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H12N2O
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| Canonical SMILES |
C1=CC=C(C=C1)C2=NC3=C(C=CC=C3C(=O)N)C=C2
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| InChI |
1S/C16H12N2O/c17-16(19)13-8-4-7-12-9-10-14(18-15(12)13)11-5-2-1-3-6-11/h1-10H,(H2,17,19)
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| InChIKey |
BNQJEMTZUOVMLM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. | |||
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