Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W9KE
|
|||
| Former ID |
DIB012479
|
|||
| Drug Name |
AS-1708727
|
|||
| Indication | Hypertriglyceridemia [ICD-11: 5C80.1; ICD-10: E78.1, E78.3; ICD-9: 272.1, 427] | Investigative | [1] | |
| Company |
Astellas Pharma Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Forkhead box protein O1A (FOXO1) | Target Info | Modulator | [1] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Insulin/IGF pathway-protein kinase B signaling cascade | |||
| PI3 kinase pathway | ||||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Signaling events mediated by HDAC Class III | ||||
| Angiopoietin receptor Tie2-mediated signaling | ||||
| CXCR4-mediated signaling events | ||||
| FoxO family signaling | ||||
| Regulation of Androgen receptor activity | ||||
| IL6-mediated signaling events | ||||
| Class I PI3K signaling events mediated by Akt | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice. Eur J Pharmacol. 2010 Oct 25;645(1-3):185-91. | |||
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