Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0W8HP
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| Former ID |
DIB008458
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| Drug Name |
MEDI-543
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| Synonyms |
MEDI-EphA2; L/A Lm-MCMV vaccine, Cerus/MedImmune; Listeria monocytogenes-based immunotherapy (EphA2-targeting), Cerus; Listeria monocytogenes-based immunotherapy (EphA2-targeting), Cerus/MedImmune; Live-attenuated Listeria monocytogenes (Lm)-based vaccine (CMV), Cerus/MedImmune
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| Drug Type |
Vaccine
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Preclinical | [1] | |
| Company |
Cerus Corp
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ephrin type-A receptor 2 (EPHA2) | Target Info | . | [2] |
| KEGG Pathway | Ras signaling pathway | |||
| Rap1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Axon guidance | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathway Interaction Database | EphrinA-EPHA pathway | |||
| Arf6 signaling events | ||||
| Direct p53 effectors | ||||
| EPHA forward signaling | ||||
| Stabilization and expansion of the E-cadherin adherens junction | ||||
| EPHA2 forward signaling | ||||
| Reactome | EPH-Ephrin signaling | |||
| EPHA-mediated growth cone collapse | ||||
| EPH-ephrin mediated repulsion of cells | ||||
| WikiPathways | NRF2 pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016645) | |||
| REF 2 | Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer. Cancer Biol Ther. 2010 Dec 15;10(12):1306-14. | |||
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