Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0W7XH
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| Former ID |
DNC002340
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| Drug Name |
DR2313
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| Drug Type |
Small molecular drug
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| Indication | Stroke [ICD-11: 8B20; ICD-10: G45.9, I61-I63; ICD-9: 434.91, 435.9] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C8H10N2OS
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| Canonical SMILES |
CC1=NC2=C(CSCC2)C(=O)N1
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| InChI |
1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
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| InChIKey |
HRYKZAKEAVZGJD-UHFFFAOYSA-N
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| CAS Number |
CAS 284028-90-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15219719, 22608712, 26759382, 40334200, 47211760, 50112881, 57374403, 77559784, 85788202, 99238636, 99246552, 99444148, 103652092, 104120157, 118845236, 121503098, 123392404, 125346955, 126576933, 126629926, 126734873, 132573658, 134964469, 160829200, 160968747, 162023498, 163093889, 163389609, 163687471, 164831363, 165239256, 170482091, 174555355, 202544456, 206247125, 211786564, 218190634, 223573625, 226746836, 240064958, 248372641, 252156560, 252160010, 252218095
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40. | |||
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