Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0UI7U
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| Former ID |
DIB020373
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| Drug Name |
ML315
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| Synonyms |
ML315; CHEMBL1885748; 1440251-53-5; MLS004256649; GTPL8162; KUC107550N; BDBM50435474; ML 315; AKOS032952995; KSC-14-101; NCGC00241342-01; NCGC00241342-02; SMR003081704; BRD-K98168317-001-01-9; 5-(benzo[d][1,3]dioxol-5-yl)-N-(3,5-dichlorobenzyl)pyrimidin-4-amine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C18H13Cl2N3O2
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| Canonical SMILES |
C1OC2=C(O1)C=C(C=C2)C3=CN=CN=C3NCC4=CC(=CC(=C4)Cl)Cl
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| InChI |
1S/C18H13Cl2N3O2/c19-13-3-11(4-14(20)6-13)7-22-18-15(8-21-9-23-18)12-1-2-16-17(5-12)25-10-24-16/h1-6,8-9H,7,10H2,(H,21,22,23)
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| InChIKey |
JQSJAVBMIMDUFO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CDC-like kinase 1 (CLK1) | Target Info | Inhibitor | [1] |
| CDC-like kinase 2 (CLK2) | Target Info | Inhibitor | [1] | |
| CDC-like kinase 4 (CLK4) | Target Info | Inhibitor | [1] | |
| Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) | Target Info | Inhibitor | [1] | |
| NetPath Pathway | TCR Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| WikiPathways | mRNA Processing | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. | |||
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