Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0T5NX
|
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| Former ID |
DNC002285
|
|||
| Drug Name |
ISIS 148715
|
|||
| Drug Type |
Antisense drug
|
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Company |
Isis Pharmaceuticals
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Jagged2 messenger RNA (JAG2 mRNA) | Target Info | . | [1] |
| KEGG Pathway | Notch signaling pathway | |||
| Panther Pathway | Angiogenesis | |||
| Notch signaling pathway | ||||
| Pathway Interaction Database | Notch signaling pathway | |||
| p73 transcription factor network | ||||
| Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | |||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 t(7 | ||||
| M1580_K2555) Translocation Mutant | ||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
| NOTCH2 Activation and Transmission of Signal to the Nucleus | ||||
| WikiPathways | Notch Signaling Pathway | |||
| Signaling by NOTCH3 | ||||
| Signaling by NOTCH4 | ||||
| Signaling by NOTCH1 | ||||
| Signaling by NOTCH2 | ||||
| Notch Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | US patent application no. 7,425,545, Modulation of C-reactive protein expression. | |||
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